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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2018

Open Access 01-12-2018 | Research article

Genotoxicity evaluation of So-ochim-tang-gamibang (SOCG), a herbal medicine

Authors: Mi Young Lee, Yang-Chun Park, Mirim Jin, Eunseok Kim, Jeong June Choi, In Chul Jung

Published in: BMC Complementary Medicine and Therapies | Issue 1/2018

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Abstract

Background

So-ochim-tang-gamibang (SOCG) is a traditional Korean medicine frequently used for depression in the clinical field. In this study, we evaluated the potential genotoxicity of SOCG using three standard batteries of tests as part of a safety evaluation.

Methods

SOCG was evaluated for potential genotoxic effects using the standard three tests recommended by the Ministry of Food and Drug Safety (MFDS) of Korea. These tests were the bacterial reverse mutation test (Ames test), in vitro mammalian chromosomal aberration test using Chinese hamster lung cells, and in vivo micronucleus test using ICR mice.

Results

The Ames test with Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 and the Escherichia coli strain WP2uvrA(pKM101) showed that SOCG did not induce gene mutations at any dose level in all of the strains. SOCG did not induce any chromosomal aberrations in the in vitro chromosomal aberration test (for both the 6 and 24 h test) and the in vivo micronucleus test.

Conclusions

Based on the results of these tests, it was concluded that SOCG does not exhibit any genotoxic risk under the experimental conditions of this study.
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Metadata
Title
Genotoxicity evaluation of So-ochim-tang-gamibang (SOCG), a herbal medicine
Authors
Mi Young Lee
Yang-Chun Park
Mirim Jin
Eunseok Kim
Jeong June Choi
In Chul Jung
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2018
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-018-2111-2

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