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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2017

Open Access 01-12-2017 | Research article

Efficacy and safety of Jianzhong decoction in treating peptic ulcers: a meta-analysis of 58 randomised controlled trials with 5192 patients

Authors: Yan Sun, Jinping Zhang, Yuanyuan Chen

Published in: BMC Complementary Medicine and Therapies | Issue 1/2017

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Abstract

Background

Jianzhong decoction is widely used to treat peptic ulcers; however, due to lack of systematic evaluations, its clinical efficacy remains controversial. We performed meta-analysis to evaluate the efficacy and safety of Jianzhong decoction in treating peptic ulcers.

Methods

Studies were systematically retrieved from PubMed, Embase, Cochrane library, China National Knowledge Infrastructure, Wanfang Database, Chongqing VIP, China Biology Medicine disc (CBMdisc), and references cited in related studies/reviews. Extracted data included the total effective rate, helicobacter pylori eradication rates, recurrence rate, and adverse reaction rate. Fifty-eight randomised controlled trials involving 5192 patients were included in the final analysis.

Results

Results showed that Jianzhong decoction therapy was more effective than conventional Western medicine therapy (total effective rate, odds ratio [OR] = 4.29, 95% confidence interval [CI]: 3.51–5.23, P = 0.000; helicobacter pylori eradication rates, OR =2.10, 95% CI: 1.69–2.61, P = 0.000; recurrence rate, OR =0.23, 95% CI: 0.18–0.29, P = 0.000; and adverse reaction rate, OR =0.20, 95% CI: 0.12–0.33, P = 0.000).

Conclusions

Jianzhong decoction increased the total effective rate and helicobacter pylori eradication rate, and lowered the recurrence and adverse reaction rates. The results of this study can be used as a guide for clinical treatment of peptic ulcers.
Appendix
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Literature
1.
Moller MH, Adamsen S, Thomsen RW, Moller AM. Peptic Ulcer Perforation trial, Multicentre trial of a perioperative protocol to reduce mortality in patients with peptic ulcer perforation. Br J Surg. 2011;98(6):802–10.CrossRefPubMed
2.
Chu S, Wang Y. A meta-analysis of Banxiaxiexin Tang combined with omeprazole for the treatment for peptic ulcer. Res Integrated Tradit Chin West Medi. 2014;6(1):1–5.
3.
Rosenstock S, Jorgensen T, Bonnevie O, et al. Risk factors for peptic ulcer disease: A population Based prospective cohort study com-prising 2416 Danish adults. Gut. 2009;52(1):186–93.
4.
Qian L. Application of Xiaojianzhong decoction in peptic ulcer. Guangming J Chin Med. 2008;23(7):1021–2.
5.
Shi Z, Wang X. A study of the therapeutic efficacy of Xiaojianzhong decoction combined with Western medicine on spleen deficiency-type PU and its effect on serum, gastric juice EGF and gastric mucosal EGFR. World J Integrated Tradit West Med. 2016;11(5):703–6.
6.
Zhu X, Ge H, Yun H. Treatment of 22 peptic ulcer patients with modified Jianzhong decoction. Traditional Chin Med Res. 2009;22(10):22–3.
7.
Jadad AR, Moore RA, Carroll D. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials. 1996;17(1):1–12.CrossRefPubMed
8.
Nie J. Analysis of the therapeutic efficacy of Xiaojianzhong decoction and pill of Galanga and Cyperus combined with Western medicine on the spleen deficiency-type peptic ulcer. Jilin Med J. 2016;37(3):664–5.
9.
Guo R. Therapy of integrated medicine in the treatment of peptic ulcer disease for 78 cases. Chin Med Mod Distance Educ China. 2016;14(12):103–5.
10.
Xie D. Study of the therapeutic efficacy of modified Xiaojianzhong decoction in patients with peptic ulcer. Cardiovasc Dis J Integrated Tradit Chin West Med. 2016;4(19):166–7.
11.
Cai Q. Observation on the therapeutic efficacy of Xiaojianzhong decoction in 36 patients with spleen deficiency-type peptic ulcer. Jiankang Qianyan. 2016;23(6):161–2.
12.
Li J, Fan C, Wang Q. A clinical analysis of treating peptic ulcer of Piwei Xuhan type with the Xiaojianzhong decoction plus anti-Helicobacter pylori. Clin J Chin Med. 2016;8(10):80–2.
13.
Li J. Clinical analysis of Huangqi Jianzhong decoction in treating the spleen deficiency-type gastric ulcer. Shenzhen J Integrated Tradit Chin West Med. 2015;25(22):54–5.
14.
Yang C. Clinical study of integrated Chinese and Western medicine in treating the spleen deficiency-type peptic ulcer. Asia Pac J Tradit Chin Med. 2015;11(6):94–5.
15.
Wang H. Clinical effects observation of Huangqi Jianzhong decoction combined with Western medicine on recurrence of peptic ulcer. Clin J Chin Med. 2015;7(12):74–5.
16.
Li X. A randomised parallel controlled trial of Xiaojianzhong decoction in treating the spleen deficiency-type peptic ulcer. J Pract Tradit Chin Intern Med. 2015;29(5):100–1.
17.
Yang Z, You G. Analysis of the therapeutic efficacy of Xiaojianzhong and pill of Galanga and Cyperus on spleen deficiency-type peptic ulcer. Health Care Today B. 2015;11(22):218.
18.
Han B. Analysis of clinical efficacy of Huangqi Jianzhong decoction on the duodenal ulcer. Contemporary Med Forum. 2015;13(3):24–5.
19.
Wen L. Study of the clinical efficacy of Xiaojianzhong decoction on the spleen deficiency-type peptic ulcer. Med Inf. 2015;28(18):224–5.
20.
Gao S. Clinical study of treatment of peptic ulcer with traditional Chinese medicine. Med Aesthetics Cosmetology. 2015;5(5):297.
21.
Zhang J. Clinical study of Xiaojianzhong decoction and pill of Galanga and Cyperus combined with Western medicine in treating the spleen deficiency-type peptic ulcer. Contemporary Med Forum. 2014;12(2):304–5.
22.
Dong N, Xu Y, Sun N. Clinical observation on the treatment of 36 peptic ulcer patients treated with Xiaojianzhong decoction. Nei Mongol J Tradit Chin Med. 2014;33(22):40.
23.
Liu CH, Liu C. Efficacy observation of duodenal ulcer of aged people treated with Huangqi Jianzhong decoction (Traditional Chinese Medicine Formula Granules) and Rabeprazole. Liaoning J Tradit Chin Med. 2014;41(2):259–61.
24.
Wu Q. Analysis of 50 gastric ulcer patients treated with Huangqi Jianzhong decoction. Med People. 2014;27(5):138–9.
25.
Gan G. Treatment of 53 peptic ulcer patients using the modified Xiaojianzhong decoction. China Health Care Nutr. 2014;2(4):2336–7.
26.
Xi S, Qian L, Qian X. Treatment of 62 peptic ulcer patients with the modified Xiaojianzhong decoction. J Tradit Chin Med. 2013;54(8):703–4.
27.
Fan W, He Q. Clinical observation on the treatment of spleen deficiency-type peptic ulcer with Xiaojianzhong decoction combined with Anti-Helicobacter pylori. Guangming J Chin Med. 2013;28(8):1670–2.
28.
Yu B. Clinical study of the treatment of spleen deficiency-type peptic ulcer with Xiaojianzhong decoction and pill of Galanga and Cyperus combined with Western medicine. Guide China Med. 2013;11(32):518–9.
29.
Li S, Wei H, Huang D. Modified Xiaojianzhong decoction treating 68 cases of peptic ulcer of the spleen-stomach deficiency cold type. World Chin Med. 2013;8(11):1303–4.
30.
Fu Y, Wan Y. Clinical study of the treatment of spleen deficiency-type peptic ulcer with Xiaojianzhong decoction. Contemporary Med. 2013;19(34):155–6.
31.
Wu Y. Observation on the therapeutic efficacy of traditional Chinese medicine combined with triple therapy on Helicobacter pylori-associated duodenal ulcer. Guide China Med. 2013;11(1):273–4.
32.
Si A. Clinical observation on 58 cases of gastric ulcer treated with Huangqi Jianzhong decoction. China Pract Med. 2013;8(4):169.
33.
Wu W. Observation on the therapeutic efficacy of Xiaojianzhong decoction on peptic ulcer. China Health Care Nutr. 2013;23(5):2723–4.
34.
Bi M, Peng Q, Tong C. Clinical observation on the treatment of spleen deficiency-type peptic ulcer with Huangqi Jianzhong decoction. Hubei J Tradit Chin Med. 2013;35(2):50–1.
35.
Li R, Ke J. Observation on the therapeutic efficacy of Xiaojianzhong decoction combined with Western medicine on peptic ulcer. Clin Med Eng. 2012;19(1):67–8.
36.
Zou Y, Li W, Song G. Treatment of 45 cases of peptic ulcer with modified Xiaojianzhong decoction combined with Western medicine. J Bingtuan Med. 2012;32(2):24–6.
37.
Deng Y, Wu J, Zhang A. Clinical experience of 38 cases of peptic ulcer treated with integrated Traditional Chinese medicine and Western medicine. Chin J Mod Drug Appl. 2012;6(4):94–5.
38.
Li X. The comparison of healing rate and Hp eradication rate of duodenal ulcer between Huangqi Jianzhong decoction combined with Western medicine and Western medicine alone. Guide China Med. 2012;10(18):266–7.
39.
Cao A. Observation on the therapeutic efficacy of Xiaojianzhong decoction on the peptic ulcer. Public Med Forum Mag. 2011;15(29):905–6.
40.
Dan J. Effect of integrated traditional Chinese medicine and Western medicine on the expression of NO and IL-17 in patients with peptic ulcer. J Emerg Tradit Chin Med. 2011;20(12):1920–1.
41.
Hu J, Xie C. Clinical observation on 75 cases of peptic ulcer treated with Xiaojianzhong decoction. Hunan J Tradit Chin Med. 2011;27(6):28–9.
42.
Jiang Y. Treatment of 65 cases of peptic ulcer with integrated traditional Chinese medicine and Western medicine. China’s Naturopathy. 2011;19(8):57.
43.
Yi L. Observation on the therapeutic efficacy of integrated traditional Chinese medicine and Western medicine in 50 cases of peptic ulcer. Chin Foreign Health Abstr. 2011;8(18):210–1.
44.
Wu G. Treatment of 45 cases of recurrent spleen deficiency-type peptic ulcer with modified Xiaojianzhong decoction. Henan Tradit Chin Med. 2010;30(1):23–4.CrossRef
45.
Wu L. Clinical observation on the treatment of peptic ulcer with modified Huangqi Jianzhong decoction. Gansu Sci Technol. 2010;26(14):150–71.
46.
Li X. Observation on the therapeutic efficacy of Huangqi Jianzhong decoction combined with temperature-sensitive acupuncture point paste on the peptic ulcer. Chin J Misdiagnosis. 2010;10(21):5120–1.
47.
Cui B. Clinical observation on 70 cases of peptic ulcer treated with integrated traditional Chinese medicine and Western medicine. J Clin Exp Med. 2009;8(12):77–8.
48.
Gao Y, Li J, Zeng Y. Observation on the therapeutic efficacy of Huangqi Jianzhong decoction combined with Western medicine in 62 cases of peptic ulcer. Jilin J Tradit Chin Med. 2009;29(6):481–2.
49.
Zhan S, Tan Y. Treatment of 60 cases of peptic ulcer with modified Huangqi Jianzhong decoction. Hunan J Tradit Chin Med. 2009;25(2):57–8.
50.
Li Y, Bo Y. TCM-WM treatment of 40 cases of peptic ulcer. J Pract Tradit Chin Intern Med. 2009;23(5):64–5.
51.
Pan D. Clinical observation on 39 cases of peptic ulcer treated with integrated traditional Chinese medicine and Western medicine. China Pract Med. 2008;3(22):98–9.
52.
Nong Z. Clinical observation on recurrence of peptic ulcer by the treatment of Huangqijianzhong soup combined with Western medicine. J Liaoning Univ Tradit Chin Med. 2008;10(7):85–6.
53.
Zhou X. Clinical observation on the treatment of 45 cases of upper gastrointestinal ulcer with integrated traditional Chinese medicine and Western medicine. Forum Tradit Chin Med. 2008;23(6):39.
54.
Zhao X, Lei J, Sun Z. Treatment of 120 cases of spleen deficiency-type gastric ulcer with integrated traditional Chinese medicine and Western medicine. J Shaanxi Coll Tradit Chin Med. 2008;31(5):31–2.
55.
Huang H. Clinical observation on the treatment of 25 cases of peptic ulcer with modified Xiaojianzhong decoction. Guiding J Tradit Chin Med Pharm. 2007;13(6):38–9.
56.
Wang Z. A summary of 40 cases of peptic ulcer treated with Huangqi Jianzhong decoction. Hunan J Tradit Chin Med. 2007;23(4):19–20.
57.
Gao X. Treatment of 80 cases of duodenal ulcer with integrated traditional Chinese medicine and Western medicine. Shanxi J Tradit Chin Med. 2006;22(S1):15.
58.
Chen Y. Effect of modified Huangqi Jianzhong decoction on the expression of bFGF in gastric mucosa of gastric ulcer. Hunan J Tradit Chin Med. 2005;21(6):13–4.
59.
Tang Q. Treatment of 20 cases of duodenal ulcer with modified Huangqi Jianzhong decoction. Hunan J Tradit Chin Med. 2002;18(6):34.
60.
Cai L. Observation on the therapeutic efficacy of Huangqi Jianzhong decoction in 56 cases of peptic ulcer. Shenzhen J Integrated Tradit Chin West Med. 2001;11(1):34–5.
61.
Hou A. Treatment of 100 cases of peptic ulcer with modified Huangqi Jianzhong decoction. J Pract Tradit Chin Med. 2001;17(4):16.
62.
Qian C. Observation on the therapeutic efficacy of Huangqi Jianzhong decoction and triple therapy on duodenal ulcer. Jilin J Tradit Chin Med. 2000;3(3):50.
63.
Chen H. Investigation of the treatment of duodenal ulcer with omeprazole combined with Huangqi Jianzhong decoction. Chin J Integrated Tradit West Med Digestion. 1997;5(3):177.
64.
65.
Farzaei MH, Rahimi R, Abdollahi M, Abbasabadi Z. An Evidence-based Review on Medicinal Plants used for the Treatment of Peptic Ulcer in Traditional Iranian Medicine. Int J Pharmacol. 2013;9(2):108–24.CrossRef
66.
Berrutti M, Astegiano M, Smedile A, et al. Efficacy of amoxicillin plus clavulanic acid-based triple therapy for Helicobacter pylori eradication: A retrospective study. Pan Minerva Med. 2010;52(4):361–2.
67.
Lin LC, Hsu TH, Huang KW, Tam KW. Nonbismuth concomitant quadruple therapy for Helicobacter pylori eradication in Chinese regions: A meta-analysis of randomized controlled trials. World J Gastroenterol. 2016;22(23):5445–53.CrossRefPubMedPubMedCentral
68.
Gisbert JP, Pajares JM. Systematic review and meta-analysis: is 1-week proton pump inhibitor-based triple therapy sufficient to heal peptic ulcer? Aliment Pharmacol Ther. 2005;21(7):795–804.CrossRefPubMed
69.
Huang CY, Lai WY, Sun MF, et al. Prescription patterns of traditional Chinese medicine for peptic ulcer disease in Taiwan: A nationwide population-based study. J Ethnopharmacol. 2015;12(176):311–120.CrossRef
70.
Cohen S, Bueno de Mesquita M, Mimouni FB. Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review. Br J Clin Pharmacol. 2015;80(2):200–8.CrossRefPubMedPubMedCentral
71.
Khoshbaten M, Ghaffarifar S, Jabbar Iman A, et al. Effects of early oral feeding on relapse and symptoms of upper gastrointestinal bleeding in peptic ulcer disease. Dig Endosc. 2013;25(2):125–9.CrossRefPubMed
72.
Liao H. Effects of Shengjiang (Zingiberis Rhizoma Recens) and Its Processed Products on Nitric Oxide Production in Macrophage RAW 264.7 Cells. Evid Based Complement Alternat Med. 2015;2015:828156.PubMedPubMedCentral
73.
Sun Y, Guo M, Feng Y, Zheng H, Lei P, Ma X, Han X, Guan H, Hou D. Effect of ginseng polysaccharides on NK cell cytotoxicity in immunosuppressed mice. Exp Ther Med. 2016;12(6):3773–7.PubMedPubMedCentral
74.
Khemawoot P, Hunsakunachai N, Anukunwithaya T, Bangphumi K, Ongpipattanakul B, Jiratchariyakul W, Soawakontha R, Inthachart T, Dechatiwongse Na Ayudhya T, Koontongkaew S, Poachanukoon O. Pharmacokinetics of Compound D, the Major Bioactive Component of Zingiber cassumunar. Rats Planta Med. 2016;82(13):1186–91.CrossRefPubMed
75.
Wei P, Huo HL, Ma QH, Li HC, Xing XF, Tan XM, Luo JB. Pharmacokinetic comparisons of five ephedrine alkaloids following oral administration of four different Mahuang-Guizhi herb-pair aqueous extracts ratios in rats. J Ethnopharmacol. 2014;155(1):642–8.CrossRefPubMed
76.
Bae M, Jang S, Lim JW, Kang J, Bak EJ, Cha JH, Kim H. Protective effect of Korean Red Ginseng extract against Helicobacter pylori-induced gastric inflammation in Mongolian gerbils. J Ginseng Res. 2014;38(1):8–15.CrossRefPubMed
Metadata
Title
Efficacy and safety of Jianzhong decoction in treating peptic ulcers: a meta-analysis of 58 randomised controlled trials with 5192 patients
Authors
Yan Sun
Jinping Zhang
Yuanyuan Chen
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2017
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-017-1723-2

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