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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2016

Open Access 01-12-2016 | Research article

Hepatoprotective effect of Quercetin supplementation against Acrylamide-induced DNA damage in wistar rats

Authors: Sabah Ansar, Nikhat Jamal Siddiqi, Seema Zargar, Majid Ahmad Ganaie, Manal Abudawood

Published in: BMC Complementary Medicine and Therapies | Issue 1/2016

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Abstract

Background

Quercetin (QR), is a polyphenolic flavonoid compound which is found in large amounts in certain foods, and protects against oxidative stress. The current study was conducted to determine whether Quercetin can possibly exert hepatoprotective and antioxidant activity against acrylamide (ACR) induced toxicity in rats.

Methods

Four groups of Wistar rats consisting of six rats each: (i) control group; (ii) ACR treated group (50 mg/kg bw); (iii) QR group: rats were treated with QR (10 mg/kg bw); (iv) QR (10 mg/kg bw) was given i.p. for 5 days followed by ACR (50 mg/kg bw) on 5th day (single dose).

Results

ACR caused an elevation in 8-OH guanosine level and a reduction in Glutahione S-transferase (GST) activity. Administration of QR significantly protected liver tissue against hepatotoxic effect of acrylamide from amelioration of the marker enzyme (p < 0.05) and DNA damage (p < 0.01) as evident by comet assay and, besides some indices of histopathological alterations.

Conclusion

It is concluded that QR could protect the liver against DNA damage induced by ACR probably is thus capable of ameliorating ACR-induced changes in the rat livers.
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Metadata
Title
Hepatoprotective effect of Quercetin supplementation against Acrylamide-induced DNA damage in wistar rats
Authors
Sabah Ansar
Nikhat Jamal Siddiqi
Seema Zargar
Majid Ahmad Ganaie
Manal Abudawood
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2016
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-016-1322-7

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