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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2016

Open Access 01-12-2016 | Research article

San Huang Shel Shin Tang beta-cyclodextrin complex augmented the hepatoprotective effects against carbon tetrachloride-induced acute hepatotoxicity in rats

Authors: Yu-Lan Yeh, Wei-Jen Ting, Wei-Wen Kuo, Hsi-Hsien Hsu, Yueh-Min Lin, Chia-Yao Shen, Chung-Ho Chang, Viswanadha Vijaya Padma, Yuhsin Tsai, Chih-Yang Huang

Published in: BMC Complementary Medicine and Therapies | Issue 1/2016

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Abstract

Background

San Huang Shel Shin Tang (SHSST) is a traditional herbal decoction used as a hepato-protective agent and is composed of Rheum officinale Baill, Scutellaria baicalnsis Geprgi and Coptis chinensis Franch (2:1:1 w/w). Beta-cyclodextrin (β-CD) modification may potentially increase the solubility and spectral properties of SHSST.

Methods

In this research, the hepato-protective effects of unmodified SHSST, β-CD modified SHSST complex (SHSSTc) and silymarin were evaluated in carbon tetrachloride (CCl4) induced acute hepatotoxicity in rats.

Results

SHHSTc (40 mg/kg/day) and silymarin (100 mg/kg/day) both decreased the CCl4-induced cirrhosis pathway-related transforming growth factor beta (TGF-β) and apoptosis pathway-related caspase-8 protein expressions, but SHSST (40 mg/kg/day) did not reduce TGF-β and caspase-8 significantly . Moreover, SHHSTc (40 mg/kg/day) enhanced the activation of insulin-like growth factor 1 receptor (IGF1R) mediated survival pathway than the silymarin (100 mg/kg/day) to protect the liver from damage induced by CCl4.

Conclusions

β-CD modification promotes hepato-protective effects of SHSST and reduces the required-dosage of the SHSST.
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Metadata
Title
San Huang Shel Shin Tang beta-cyclodextrin complex augmented the hepatoprotective effects against carbon tetrachloride-induced acute hepatotoxicity in rats
Authors
Yu-Lan Yeh
Wei-Jen Ting
Wei-Wen Kuo
Hsi-Hsien Hsu
Yueh-Min Lin
Chia-Yao Shen
Chung-Ho Chang
Viswanadha Vijaya Padma
Yuhsin Tsai
Chih-Yang Huang
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2016
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-016-1127-8

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