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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2015

Open Access 01-12-2015 | Research article

Aiweixin, a traditional Uyghur medicinal formula, protects against chromium toxicity in caenorhabditis elegans

Authors: Binggen Zhu, Ping Yang, Nurahmat Mammat, Hui Ding, Junmin He, Yong Qian, Jian Fei, Kaiser Abdukerim

Published in: BMC Complementary Medicine and Therapies | Issue 1/2015

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Abstract

Background

Aiweixin (AWX) is a traditional Uyghur medicine prescription, and has been mainly used to treat heart and brain diseases for a long time. Previous studies indicated that AWX had therapeutic effects in a rat model of myocardial ischemia reperfusion injury. In this study, we investigate whether AWX has protective effects against chromium toxicity in Caenorhabditis elegans (C. elegans).

Methods

The AWX decoction was the conventional product for clinical use. It was added into M9 buffer in a certain volume for the treatment to the wild-type C. elegans and mutational worms, daf-16, glp-1(notch), daf-2, rsks-1 and eat-2. Assays for hexavalent chromium {Cr(VI)} stress and reactive oxygen species (ROS) production were used.

Results

We found that AWX at moderate contents (0.083, 0.1, 0.125 volume of AWX/total volume) increased resistance of C. elegans to Cr(VI) exposure, although higher contents of AWX are toxic for C. elegans. The protective effect of AWX was DAF-16-dependent, but independent on the DAF-2, GLP-1, RSKS-1 and EAT-2. AWX (0.1 volume of AWX/total volume) significantly reduced ROS production of C. elegans induced by Cr(VI) exposure.

Conclusion

These results indicated the AWX protected against the toxicity of Cr(VI) in C. elegans, and the oxidative stress protective mechanism in worms should be involved.
Literature
1.
China Pharmacopoeia Commission. Drug Standard of Ministry of Public Health of the Peoples Republic of China (Uyghur Medicine). Urumqi: Xinjiang Publishing House of Science, Technology and Health; 1999. p. 72.
2.
Julaiti T, Tuehong A, Wu Q. The clinical efficacy research of Aiweixin oral liquor in the treatment of coronary heart disease and myocardial ischemia. J Med Pharm Chin Minor. 2009;15:10–3.
3.
Wang R, Wang L, Liu Y. Research on the protective effects of Aiweixin ischemia-reperfusion injury in liquid in myocardial rats. J Xinjiang Med Univ. 2009;32:146–9.
4.
Yuan YM, Wang L, Wang R. Influence of Aiweixin oral liquor on MPO and MDA in MIRI rat. J Xinjiang Med Univ. 2010;33:33–5.
5.
Bagchi D, Stohs SJ, Downs BW, Bagchi M, Preuss HG. Cytotoxicity and oxidative mechanisms of different forms of chromium. Toxicology. 2002;180:5–22.CrossRefPubMed
6.
Bagchi D, Stohs SJ, Downs BW, Bagchi M, Preuss HG. Reply to the editor: Cytotoxicity and oxidative mechanisms of different forms of chromium. Toxicology. 2003;186:175–7.CrossRef
7.
Wu Q, Qu Y, Li X, Wang D. Chromium exhibits adverse effects at environmental relevant concentrations in chronic toxicity assay system of nematode Caenorhabditis elegans. Chemosphere. 2012;87:1281–7.CrossRefPubMed
8.
Leung MCK, Williams PL, Benedetto A, Au A, Helmcke KJ, Aschner M, et al. Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol Sci. 2008;106:5–28.CrossRefPubMedPubMedCentral
9.
Shen L, Xiao J, Ye H, Wang D. Toxicity evaluation in nematode Caenorhabditis elegans after chronic metal exposure. Environ Toxicol Pharm. 2009;28:125–32.CrossRef
10.
Yang S, Zhou W, Zhang Y, Yan C, Zhao Y. Effects of Liuwei Dihuang decoction on ion channels and synaptic transmission in cultured hippocampal neuron of rat. J Ethnopharmacol. 2006;106:166–72.CrossRefPubMed
11.
Yang P, Sun R, Yao M, Chen W, Wang Z, Fei J. A C-terminal truncated mutation ofspr-3gene extends lifespan in Caenorhabditis elegans. Acta Biochim Biophys Sin. 2013;45:540–8.CrossRefPubMed
12.
Chen J, Jiang Y, Xu C, Yu L, Sun D, Xu L, et al. Comparison of two mathematical prediction models in assessing the toxicity of heavy metal mixtures to the feeding of the nematode Caenorhabditis elegans. Ecotoxicol Environ Saf. 2013;94:73–9.CrossRefPubMed
13.
Xing X, Rui Q, Wan D. Lethality toxicities induced by metal exposure during development in nematode Caenorhabditis Elegans. Bull Environ Contam Toxicol. 2009;83:530–6.CrossRefPubMed
14.
15.
Korania MS, Farbood Y, Sarkaki A, Moghaddam HF, Mansouri MT. Protective effects of gallic acid against chronic cerebral hypoperfusion-induced cognitive deficit and brain oxidative damage in rats. Eur J Pharm. 2014;733:62–7.CrossRef
16.
Lee HS, Jung SH, Yun BS, Lee KW. Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes. Arch Toxicol. 2007;81:211–8.CrossRefPubMed
17.
Salcedo CL, Frías MA, Cutro AC, Nazareno MA, Disalvo EA. Antiradical activity of gallic acid included in lipid interphases. Biochim Biophys Acta. 1838;2014:2656–61.
18.
Slamenová D, Horváthová E, Wsólová L, Sramková M, Navarová J. Investigation of anti-oxidative, cytotoxic, DNA-damaging and DNA-protective effects of plant volatiles eugenol and borneol in human-derived HepG2, Caco-2 and VH10 cell lines. Mutat Res. 2009;677:46–52.CrossRefPubMed
19.
Mukhopadhyay A, Oh SW, Tissenbaum HA. Worming pathways to and from DAF-16/FOXO. Exp Gerontol. 2006;41:928–34.CrossRefPubMed
20.
Murphy CT. The search for DAF-16/FOXO transcriptional targets: Approaches and discoveries. Exp Gerontol. 2006;41:910–21.CrossRefPubMed
21.
Baumeister R, Schaffitzel E, Hertweck M. Endocrine signaling in Caenorhabditis elegans controls stress response and longevity. J Endocrinol. 2006;190:191–202.CrossRefPubMed
22.
23.
Korta DZ, Tuck S, Hubbard EJA. S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells. Development. 2012;139:859–70.CrossRefPubMedPubMedCentral
24.
Metadata
Title
Aiweixin, a traditional Uyghur medicinal formula, protects against chromium toxicity in caenorhabditis elegans
Authors
Binggen Zhu
Ping Yang
Nurahmat Mammat
Hui Ding
Junmin He
Yong Qian
Jian Fei
Kaiser Abdukerim
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2015
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-015-0783-4

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