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BMC Women's Health
Published in: BMC Women's Health 1/2019

Open Access 01-12-2019 | Melanoma | Case report

Primary malignant melanoma arising from ruptured ovarian mature cystic teratoma with elevated serum CA 19–9: a case report and review of literature

Authors: Won Ku Choi, Dong Hyun Lee, Dong Hyu Cho, Kyu Yun Jang, Kyoung Min Kim

Published in: BMC Women's Health | Issue 1/2019

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Abstract

Background

Ovarian mature cystic teratomas comprise tissues derived from all three germ layers. In rare incidences, malignant tumors may arise from ovarian mature cystic teratoma, which occurs in 0.2–1.8% of cases. A variety of tumors can arise within mature cystic teratoma, among which malignant melanoma is exceedingly rare.

Case presentation

A 42-year-old woman presented with abdominal pain. Transvaginal ultrasonography showed mixed echogenic cystic masses in both ovaries. Her serum cancer antigen (CA19–9) level was elevated at 29,770 U/ml. Surgical excision was performed. Histologic examination showed infiltrating nests of pleomorphic cells with prominent nucleoli and black pigments in the background of a mature cystic teratoma. These pleomorphic cells showed strong immunoreactivity for Melan-A and HMB-45. The patient was re-evaluated and the possibility of a melanoma at any other site was ruled out. Based on these findings, we concluded that the malignant melanoma originated from the ovarian mature cystic teratoma.

Conclusion

We report a rare case of primary malignant melanoma derived from an ovarian mature cystic teratoma.
Literature
1.
Kurman RJ, Carcangiu ML, Herrington S, Young RH. WHO classification of tumours of female reproductive organs. 4th ed. Lyon: IARC; 2014.
2.
Crouet H, de Ranieri E, de Ranieri J. Secondary cancers arising in mature benign cystic teratomas of the ovary (dermoid cysts). Review of the literature apropos of a new case. J Gynecol Obstet Biol Reprod (Paris). 1986;15(8):1055–66.
3.
Andrews HR. Primary melanotic sarcoma of the ovary. Trans Obstet Soc. 1901;43:228–31.
4.
Liberati F, Maccio T, Ascani S, Farabi R, Lancia D, Peciarolo A, Bolis GB. Primary malignant melanoma arising in an ovarian cystic teratoma. Acta Oncol. 1998;37(4):381–3.CrossRef
5.
Shen X, Fan Y, Cao S. Primary malignant melanoma arising in an ovarian cystic teratoma. Melanoma Res. 2017;27(6):601–6.CrossRef
6.
Lee SH, Lee KB, Shin JW, Chung DH, Park CY. Ovarian malignant melanoma without evidence of teratoma. J Obstet Gynaecol Res. 2010;36(4):898–901.CrossRef
7.
Ayhan A, Aksu T, Develioglu O, Tuncer ZS, Ayhan A. Complications and bilaterality of mature ovarian teratomas (clinicopathological evaluation of 286 cases). Aust N Z J Gynaecol. 1991;31(1):83–5.CrossRef
8.
Young RH, Scully RE. Malignant melanoma metastatic to the ovary. A clinicopathologic analysis of 20 cases. Am J Surg Pathol. 1991;15(9):849–60.CrossRef
9.
Boughton RS, Hughmanick S, Marin-Padilla M. Malignant melanoma arising in an ovarian cystic teratoma in pregnancy. J Am Acad Dermatol. 1987;17(5):871–5.CrossRef
10.
Cronje HS, Woodruff JD. Primary ovarian malignant melanoma arising in cystic teratoma. Gynecol Oncol. 1981;12(3):379–83.CrossRef
11.
Cho HY, Kim K, Jeon YT, Kim YB, No JH. CA19-9 elevation in ovarian mature cystic teratoma: discrimination from ovarian cancer–CA19-9 level in teratoma. Medi Sci Monit. 2013;19:230.CrossRef
12.
Vimla N, Kumar L, Thulkar S, Bal S, Dawar R. Primary malignant melanoma in ovarian cystic teratoma. Gynecol Oncol. 2001;82(2):380–3.CrossRef
13.
Hyun HS, Mun ST. Primary malignant melanoma arising in a cystic teratoma. Obstet Gynecol Sci. 2013;56(3):201–4.CrossRef
14.
Pantoja E, Rodriguez-Ibanez I, Axtmayer RW, Noy MA, Pelegrina I. Complications of dermoid tumors of the ovary. Obstet Gynecol. 1975;45(1):89–94.PubMed
15.
Davis GL. Malignant melanoma arising in mature ovarian cystic teratoma (dermoid cyst). Report of two cases and literature analysis. Int J Gynecol Pathol. 1996;15(4):356–62.CrossRef
Metadata
Title
Primary malignant melanoma arising from ruptured ovarian mature cystic teratoma with elevated serum CA 19–9: a case report and review of literature
Authors
Won Ku Choi
Dong Hyun Lee
Dong Hyu Cho
Kyu Yun Jang
Kyoung Min Kim
Publication date
01-12-2019
Publisher
BioMed Central
Keywords
Melanoma
Melanoma
Published in
BMC Women's Health / Issue 1/2019
Electronic ISSN: 1472-6874
DOI
https://doi.org/10.1186/s12905-019-0853-8

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