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Open Access 01-12-2019 | Infertility | Research article

Age-specific values of Access anti-Müllerian hormone immunoassay carried out on Japanese patients with infertility: a retrospective large-scale study

Authors: Tomoya Segawa, Kenji Omi, Yoshiaki Watanabe, Yaeko Sone, Masaki Handa, Masako Kuroda, Osamu Miyauchi, Hisao Osada, Shokichi Teramoto

Published in: BMC Women's Health | Issue 1/2019

Abstract

Background

The ovarian reserve in women is known to correlate with anti-Müllerian hormone (AMH) levels, and currently the latest, third-generation, fully-automated AMH immunoassays, such as Access and Cobas, are beginning to be used for measuring AMH levels. However, the age-specific reference values obtained for AMH levels have been based on samples from an American population, measured using first-generation immunoassays. In this study, we attempted to determine the age-specific AMH reference values based on a large set of samples taken from Japanese infertile women measured by Access so that they could be used by infertility centers treating Japanese and those with similar racial and life-style characteristics.

Methods

The study included 5483 Japanese patients who enrolled in infertility treatment programs at two in-vitro fertilization centers, Shimbashi YUME Clinic and Natural ART Clinic Nihombashi in Tokyo, and who had their serum AMH levels measured between December 2015 and November 2017 by Access. Each patient was represented only once in the study. The mean, median, and standard deviation values were obtained from the measured values for single-year intervals from 28 through 48 years of age (21 age groups in total). The 3D-fitted curve of age-specific mean and median values measured by Access was obtained by regression analysis.

Results

The mean and median values decreased with advancing age (mean: R² = 0.9864; median: R² = 0.9926). In all age groups, the mean values were higher than the median values; however, the differences between these values decreased with increasing age.

Conclusions

The age-specific AMH reference values measured by Access in this study may serve as a useful diagnostic marker in infertility centers, especially those treating Japanese patients or patients with similar characteristics.

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Title: Age-specific values of Access anti-Müllerian hormone immunoassay carried out on Japanese patients with infertility: a retrospective large-scale study
Authors: Tomoya Segawa
Kenji Omi
Yoshiaki Watanabe
Yaeko Sone
Masaki Handa
Masako Kuroda
Osamu Miyauchi
Hisao Osada
Shokichi Teramoto
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Infertility
Infertility
Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
Published in: BMC Women's Health / Issue 1/2019
Electronic ISSN: 1472-6874
DOI: https://doi.org/10.1186/s12905-019-0752-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Age-specific values of Access anti-Müllerian hormone immunoassay carried out on Japanese patients with infertility: a retrospective large-scale study

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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