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BMC Oral Health
Published in: BMC Oral Health 1/2021

01-12-2021 | Cytokines | Research article

Analysis of IL-1β, CXCL8, and TNF-α levels in the crevicular fluid of patients with periodontitis or healthy implants

Authors: Paweł Aleksandrowicz, Ewa Brzezińska-Błaszczyk, Elżbieta Kozłowska, Paulina Żelechowska, Andrea Enrico Borgonovo, Justyna Agier

Published in: BMC Oral Health | Issue 1/2021

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Abstract

Background

Our study aimed to assess the level of IL-1β, CXCL8, and TNF-α in peri-implant sulcular fluid (PISF) collected from patients with no clinical symptoms of mucositis or peri-implantitis and compare them with cytokine concentration in gingival crevicular fluid (GCF) acquired from patients with healthy periodontium and those with varying severity of periodontitis.

Methods

A total of 189 subjects were included in the study, and GCF/PISF samples were checked for IL-1β, CXCL8, and TNF-α levels using an ELISA test.

Results

The IL-1β level in PISF in patients with implants was significantly lower than in GCF in patients with mild, moderate, or severe periodontitis. The CXCL8 level in PISF was considerably lower than in patients with moderate periodontitis. The TNF-α level in PISF in patients with implants was markedly higher compared to subjects with healthy periodontium or patients with mild periodontitis.

Conclusion

Analysis of cytokine levels may help describe the pathogenesis and early diagnosis of peri-implantitis and prevision in high-risk patients.
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Metadata
Title
Analysis of IL-1β, CXCL8, and TNF-α levels in the crevicular fluid of patients with periodontitis or healthy implants
Authors
Paweł Aleksandrowicz
Ewa Brzezińska-Błaszczyk
Elżbieta Kozłowska
Paulina Żelechowska
Andrea Enrico Borgonovo
Justyna Agier
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2021
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-021-01478-3

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