Skip to main content
Top
Published in: BMC Oral Health 1/2020

Open Access 01-12-2020 | Antibiotic | Research article

The effect of intracanal medicaments used in Endodontics on the dislocation resistance of two calcium silicate-based filling materials

Authors: Sara Alsubait, Norah Alsaad, Sumayyah Alahmari, Fatimah Alfaraj, Hussam Alfawaz, Abdullah Alqedairi

Published in: BMC Oral Health | Issue 1/2020

Login to get access

Abstract

Background

Intracanal medicaments can be used in various endodontic conditions including multiple visit endodontics after trauma or in regenerative endodontics. These medicaments should be removed from the root canal before the placement of the filling or repair material. The aim of the present study was to evaluate the effect of prior calcium hydroxide (Ca(OH)2) and modified triple antibiotic paste (mTAP) placement on the push-out bond strength of TotalFill BC fast set putty (BC fast set putty) to root dentin when compared to mineral trioxide aggregate (MTA).

Methods

The root canals of 45 extracted mandibular premolars were prepared to a standardized internal diameter (1.5 mm). The specimens were randomly assigned to 3 groups according to the intracanal medicament used: mTAP (a mixture of metronidazole, ciprofloxacin, and cefaclor), Ca(OH)2, and no intracanal medicament. After 1 week, the medicaments were removed, and the middle third of the roots were cut into two transverse sections (2.0 ± 0.05) (n = 90 slices). Thereafter, the specimens were divided into two subgroups (n = 45 each): MTA or BC putty. After 1 week, the push-out test was performed and failure mode was evaluated. The data were statistically analyzed using two-way ANOVA and Tukey’s post hoc.

Results

The application of the intracanal medicament did not significantly affect the bond strength of BC putty (p > .05). For MTA, the prior application of Ca(OH)2 or mTAP significantly decreased the dislocation resistance (p < .05). Specimens in the MTA subgroups showed an almost equal number of cohesive and mixed types of failure while the majority of the specimens in the BC putty subgroups revealed the cohesive type.

Conclusions

Ca(OH)2 and mTAP promoted lower bond strength of MTA to root dentin compared to the control group. However, the BC fast set putty bond strength to dentin was not affected by prior medication with Ca(OH)2 or mTAP.
Literature
1.
go back to reference Kakehashi S, Stanley HR, Fitzgerald RJ. The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats. Oral Surg Oral Med Oral Pathol. 1965;20:340–9.PubMedCrossRef Kakehashi S, Stanley HR, Fitzgerald RJ. The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats. Oral Surg Oral Med Oral Pathol. 1965;20:340–9.PubMedCrossRef
2.
go back to reference Moller AJ, Fabricius L, Dahlen G, Ohman AE, Heyden G. Influence on periapical tissues of indigenous oral bacteria and necrotic pulp tissue in monkeys. Scand J Dent Res. 1981;89:475–84.PubMed Moller AJ, Fabricius L, Dahlen G, Ohman AE, Heyden G. Influence on periapical tissues of indigenous oral bacteria and necrotic pulp tissue in monkeys. Scand J Dent Res. 1981;89:475–84.PubMed
3.
go back to reference Sjogren U, Figdor D, Persson S, Sundqvist G. Influence of infection at the time of root filling on the outcome of endodontic treatment of teeth with apical periodontitis. Int Endod J. 1997;30:297–306.PubMedCrossRef Sjogren U, Figdor D, Persson S, Sundqvist G. Influence of infection at the time of root filling on the outcome of endodontic treatment of teeth with apical periodontitis. Int Endod J. 1997;30:297–306.PubMedCrossRef
4.
go back to reference Siqueira JF, Magalhaes KM, Rocas IN. Bacterial reduction in infected root canals treated with 2.5% NaOCl as an irrigant and calcium hydroxide/camphorated paramonochlorophenol paste as an intracanal dressing. J Endod. 2007;33:667–72.PubMedCrossRef Siqueira JF, Magalhaes KM, Rocas IN. Bacterial reduction in infected root canals treated with 2.5% NaOCl as an irrigant and calcium hydroxide/camphorated paramonochlorophenol paste as an intracanal dressing. J Endod. 2007;33:667–72.PubMedCrossRef
5.
go back to reference Hasselgren G, Olsson B, Cvek M. Effects of calcium hydroxide and sodium hypochlorite on the dissolution of necrotic porcine muscle tissue. J Endod. 1988;14:125–7.PubMedCrossRef Hasselgren G, Olsson B, Cvek M. Effects of calcium hydroxide and sodium hypochlorite on the dissolution of necrotic porcine muscle tissue. J Endod. 1988;14:125–7.PubMedCrossRef
6.
go back to reference Siqueira JF, Lopes HP. Mechanisms of antimicrobial activity of calcium hydroxide: a critical review. Int Endod J. 1999;32:361–9.PubMedCrossRef Siqueira JF, Lopes HP. Mechanisms of antimicrobial activity of calcium hydroxide: a critical review. Int Endod J. 1999;32:361–9.PubMedCrossRef
7.
go back to reference Hoshino E, Kurihara-Ando N, Sato I, Uematsu H, Sato M, Kota K, Iwaku M. In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. Int Endod J. 1996;29:125–30.PubMedCrossRef Hoshino E, Kurihara-Ando N, Sato I, Uematsu H, Sato M, Kota K, Iwaku M. In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. Int Endod J. 1996;29:125–30.PubMedCrossRef
8.
go back to reference Bose R, Nummikoski P, Hargreaves K. A retrospective evaluation of radiographic outcomes in immature teeth with necrotic root canal systems treated with regenerative endodontic procedures. J Endod. 2009;35:1343–9.PubMedCrossRef Bose R, Nummikoski P, Hargreaves K. A retrospective evaluation of radiographic outcomes in immature teeth with necrotic root canal systems treated with regenerative endodontic procedures. J Endod. 2009;35:1343–9.PubMedCrossRef
9.
go back to reference Ozan U, Er K. Endodontic treatment of a large cyst-like periradicular lesion using a combination of antibiotic drugs: a case report. J Endod. 2005;31:898–900.PubMedCrossRef Ozan U, Er K. Endodontic treatment of a large cyst-like periradicular lesion using a combination of antibiotic drugs: a case report. J Endod. 2005;31:898–900.PubMedCrossRef
10.
go back to reference Kim JH, Kim Y, Shin SJ, Park JW, Jung IY. Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report. J Endod. 2010;36:1086–91.PubMedCrossRef Kim JH, Kim Y, Shin SJ, Park JW, Jung IY. Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report. J Endod. 2010;36:1086–91.PubMedCrossRef
11.
go back to reference Thibodeau B, Trope M. Pulp revascularization of a necrotic infected immature permanent tooth: case report and review of the literature. Pediatr Dent. 2007;29:47–50.PubMed Thibodeau B, Trope M. Pulp revascularization of a necrotic infected immature permanent tooth: case report and review of the literature. Pediatr Dent. 2007;29:47–50.PubMed
12.
go back to reference Dawood AE, Parashos P, Wong RHK, Reynolds EC, Manton DJ. Calcium silicate-based cements: composition, properties, and clinical applications. J Investig Clin Dent. 2017;8(2):e12195.CrossRef Dawood AE, Parashos P, Wong RHK, Reynolds EC, Manton DJ. Calcium silicate-based cements: composition, properties, and clinical applications. J Investig Clin Dent. 2017;8(2):e12195.CrossRef
13.
go back to reference Lee SJ, Monsef M, Torabinejad M. Sealing ability of a mineral trioxide aggregate for repair of lateral root perforations. J Endod. 1993;19:541–4.PubMedCrossRef Lee SJ, Monsef M, Torabinejad M. Sealing ability of a mineral trioxide aggregate for repair of lateral root perforations. J Endod. 1993;19:541–4.PubMedCrossRef
14.
go back to reference Sousa CJ, Loyola AM, Versiani MA, Biffi JC, Oliveira RP, Pascon EA. A comparative histological evaluation of the biocompatibility of materials used in apical surgery. Int Endod J. 2004;37:738–48.PubMedCrossRef Sousa CJ, Loyola AM, Versiani MA, Biffi JC, Oliveira RP, Pascon EA. A comparative histological evaluation of the biocompatibility of materials used in apical surgery. Int Endod J. 2004;37:738–48.PubMedCrossRef
15.
go back to reference Nair PN, Duncan HF, Ford TRP, Luder HU. Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with mineral trioxide aggregate: a randomized controlled trial. 2008. Int Endod J. 2009;42:422–44.PubMedCrossRef Nair PN, Duncan HF, Ford TRP, Luder HU. Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with mineral trioxide aggregate: a randomized controlled trial. 2008. Int Endod J. 2009;42:422–44.PubMedCrossRef
16.
go back to reference Guo YJ, Du TF, Li HB, Shen Y, Mobuchon C, Hieawy A, Wang ZJ, Yang Y, Ma J, Haapasalo M. Physical properties and hydration behavior of a fast-setting bioceramic endodontic material. BMC Oral Health. 2016;16:23.PubMedPubMedCentralCrossRef Guo YJ, Du TF, Li HB, Shen Y, Mobuchon C, Hieawy A, Wang ZJ, Yang Y, Ma J, Haapasalo M. Physical properties and hydration behavior of a fast-setting bioceramic endodontic material. BMC Oral Health. 2016;16:23.PubMedPubMedCentralCrossRef
17.
go back to reference Ber BS, Hatton JF, Stewart GP. Chemical modification of proroot mta to improve handling characteristics and decrease setting time. J Endod. 2007;33:1231–4.PubMedCrossRef Ber BS, Hatton JF, Stewart GP. Chemical modification of proroot mta to improve handling characteristics and decrease setting time. J Endod. 2007;33:1231–4.PubMedCrossRef
18.
go back to reference Alsubait S, Al-Haidar S, Al-Sharyan N. A comparison of the discoloration potential for endosequence bioceramic root repair material fast set putty and proroot mta in human teeth: an in vitro study. J Esthet Restor Dent. 2017;29:59–67.PubMedCrossRef Alsubait S, Al-Haidar S, Al-Sharyan N. A comparison of the discoloration potential for endosequence bioceramic root repair material fast set putty and proroot mta in human teeth: an in vitro study. J Esthet Restor Dent. 2017;29:59–67.PubMedCrossRef
19.
go back to reference Zhang W, Peng B. Tissue reactions after subcutaneous and intraosseous implantation of iRoot SP, MTA and AH plus. Dent Mater J. 2015;34:774–80.PubMedCrossRef Zhang W, Peng B. Tissue reactions after subcutaneous and intraosseous implantation of iRoot SP, MTA and AH plus. Dent Mater J. 2015;34:774–80.PubMedCrossRef
20.
go back to reference Shokouhinejad N, Nekoofar MH, Razmi H, Sajadi S, Davies TE, Saghiri MA, Gorjestani H, Dummer PM. Bioactivity of endosequence root repair material and bioaggregate. Int Endod J. 2012;45:1127–34.PubMedCrossRef Shokouhinejad N, Nekoofar MH, Razmi H, Sajadi S, Davies TE, Saghiri MA, Gorjestani H, Dummer PM. Bioactivity of endosequence root repair material and bioaggregate. Int Endod J. 2012;45:1127–34.PubMedCrossRef
21.
go back to reference Walsh RM, Woodmansey KF, Glickman GN, He J. Evaluation of compressive strength of hydraulic silicate-based root-end filling materials. J Endod. 2014;40:969–72.PubMedCrossRef Walsh RM, Woodmansey KF, Glickman GN, He J. Evaluation of compressive strength of hydraulic silicate-based root-end filling materials. J Endod. 2014;40:969–72.PubMedCrossRef
22.
go back to reference Shahi S, Rahimi S, Yavari HR, Samiei M, Janani M, Bahari M, Abdolrahimi M, Pakdel F, Aghbali A. Effects of various mixing techniques on push-out bond strengths of white mineral trioxide aggregate. J Endod. 2012;38:501–4.PubMedCrossRef Shahi S, Rahimi S, Yavari HR, Samiei M, Janani M, Bahari M, Abdolrahimi M, Pakdel F, Aghbali A. Effects of various mixing techniques on push-out bond strengths of white mineral trioxide aggregate. J Endod. 2012;38:501–4.PubMedCrossRef
23.
go back to reference Topcuoglu HS, Arslan H, Akcay M, Saygili G, Cakici F, Topcuoglu G. The effect of medicaments used in endodontic regeneration technique on the dislocation resistance of mineral trioxide aggregate to root canal dentin. J Endod. 2014;40:2041–4.PubMedCrossRef Topcuoglu HS, Arslan H, Akcay M, Saygili G, Cakici F, Topcuoglu G. The effect of medicaments used in endodontic regeneration technique on the dislocation resistance of mineral trioxide aggregate to root canal dentin. J Endod. 2014;40:2041–4.PubMedCrossRef
24.
go back to reference Nagas E, Cehreli ZC, Uyanik MO, Vallittu PK, Lassila LV. Effect of several intracanal medicaments on the push-out bond strength of ProRoot MTA and biodentine. Int Endod J. 2016;49:184–8.PubMedCrossRef Nagas E, Cehreli ZC, Uyanik MO, Vallittu PK, Lassila LV. Effect of several intracanal medicaments on the push-out bond strength of ProRoot MTA and biodentine. Int Endod J. 2016;49:184–8.PubMedCrossRef
25.
go back to reference Turk T, Ozisik B, Aydin B. Time-dependent effectiveness of the intracanal medicaments used for pulp revascularization on the dislocation resistance of MTA. BMC Oral Health. 2015;15:130.PubMedPubMedCentralCrossRef Turk T, Ozisik B, Aydin B. Time-dependent effectiveness of the intracanal medicaments used for pulp revascularization on the dislocation resistance of MTA. BMC Oral Health. 2015;15:130.PubMedPubMedCentralCrossRef
26.
go back to reference Schneider SW. A comparison of canal preparations in straight and curved root canals. Oral Surg Oral Med Oral Pathol. 1971;32:271–5.PubMedCrossRef Schneider SW. A comparison of canal preparations in straight and curved root canals. Oral Surg Oral Med Oral Pathol. 1971;32:271–5.PubMedCrossRef
27.
go back to reference Fundaoglu Küçükekenci F, Çakici F, Küçükekenci AS. Spectrophotometric analysis of discoloration and internal bleaching after use of different antibiotic pastes. Clin Oral Investig. 2019;23:161–7.PubMedCrossRef Fundaoglu Küçükekenci F, Çakici F, Küçükekenci AS. Spectrophotometric analysis of discoloration and internal bleaching after use of different antibiotic pastes. Clin Oral Investig. 2019;23:161–7.PubMedCrossRef
28.
go back to reference Athanassiadis B, Abbott PV, Walsh LJ. The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics. Aust Dent J. 2007;52:S64–82.PubMedCrossRef Athanassiadis B, Abbott PV, Walsh LJ. The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics. Aust Dent J. 2007;52:S64–82.PubMedCrossRef
29.
go back to reference Alsubait SA, Hashem Q, AlHargan N, AlMohimeed K, Alkahtani A. Comparative evaluation of push-out bond strength of ProRoot MTA, bioaggregate and biodentine. J Contemp Dent Pract. 2014;15:336–40.PubMedCrossRef Alsubait SA, Hashem Q, AlHargan N, AlMohimeed K, Alkahtani A. Comparative evaluation of push-out bond strength of ProRoot MTA, bioaggregate and biodentine. J Contemp Dent Pract. 2014;15:336–40.PubMedCrossRef
31.
go back to reference Sjogren U, Figdor D, Spangberg L, Sundqvist G. The antimicrobial effect of calcium hydroxide as a short-term intracanal dressing. Int Endod J. 1991;24:119–25.PubMedCrossRef Sjogren U, Figdor D, Spangberg L, Sundqvist G. The antimicrobial effect of calcium hydroxide as a short-term intracanal dressing. Int Endod J. 1991;24:119–25.PubMedCrossRef
32.
go back to reference Yassen GH, Chu TM, Eckert G, Platt JA. Effect of medicaments used in endodontic regeneration technique on the chemical structure of human immature radicular dentin: an in vitro study. J Endod. 2013;39:269–73.PubMedCrossRef Yassen GH, Chu TM, Eckert G, Platt JA. Effect of medicaments used in endodontic regeneration technique on the chemical structure of human immature radicular dentin: an in vitro study. J Endod. 2013;39:269–73.PubMedCrossRef
33.
go back to reference Wigler R, Dvir R, Weisman A, Matalon S, Kfir A. Efficacy of XP-endo finisher files in the removal of calcium hydroxide paste from artificial standardized grooves in the apical third of oval root canals. Int Endod J. 2017;50:700–5.PubMedCrossRef Wigler R, Dvir R, Weisman A, Matalon S, Kfir A. Efficacy of XP-endo finisher files in the removal of calcium hydroxide paste from artificial standardized grooves in the apical third of oval root canals. Int Endod J. 2017;50:700–5.PubMedCrossRef
34.
go back to reference Chou K, George R, Walsh LJ. Effectiveness of different intracanal irrigation techniques in removing intracanal paste medicaments. Aust Endod J. 2014;40:21–5.PubMedCrossRef Chou K, George R, Walsh LJ. Effectiveness of different intracanal irrigation techniques in removing intracanal paste medicaments. Aust Endod J. 2014;40:21–5.PubMedCrossRef
35.
go back to reference Shokouhinejad N, Yazdi KA, Nekoofar MH, Matmir S, Khoshkhounejad M. Effect of acidic environment on dislocation resistance of endosequence root repair material and mineral trioxide aggregate. J Dent (Tehran). 2014;11:161–6. Shokouhinejad N, Yazdi KA, Nekoofar MH, Matmir S, Khoshkhounejad M. Effect of acidic environment on dislocation resistance of endosequence root repair material and mineral trioxide aggregate. J Dent (Tehran). 2014;11:161–6.
36.
go back to reference Yassen GH, Vail MM, Chu TG, Platt JA. The effect of medicaments used in endodontic regeneration on root fracture and microhardness of radicular dentine. Int Endod J. 2013;46:688–95.PubMedCrossRef Yassen GH, Vail MM, Chu TG, Platt JA. The effect of medicaments used in endodontic regeneration on root fracture and microhardness of radicular dentine. Int Endod J. 2013;46:688–95.PubMedCrossRef
37.
go back to reference Simsek H, Coruh M, Cakici F, Kucukekenci FF, Gurbuz T, Cakici EB. Investigation of mineral content of root canal dentin after the application of various antibiotic paste using energy-dispersive X-ray detector. Microsc Res Tech. 2019;82:144–8.PubMedCrossRef Simsek H, Coruh M, Cakici F, Kucukekenci FF, Gurbuz T, Cakici EB. Investigation of mineral content of root canal dentin after the application of various antibiotic paste using energy-dispersive X-ray detector. Microsc Res Tech. 2019;82:144–8.PubMedCrossRef
38.
go back to reference Yassen GH, Sabrah AH, Eckert GJ, Platt JA. Effect of different endodontic regeneration protocols on wettability, roughness, and chemical composition of surface dentin. J Endod. 2015;41:956–60.PubMedCrossRef Yassen GH, Sabrah AH, Eckert GJ, Platt JA. Effect of different endodontic regeneration protocols on wettability, roughness, and chemical composition of surface dentin. J Endod. 2015;41:956–60.PubMedCrossRef
39.
go back to reference Gokturk H, Bayram E, Bayram HM, Aslan T, Ustun Y. Effect of double antibiotic and calcium hydroxide pastes on dislodgement resistance of an epoxy resin-based and two calcium silicate-based root canal sealers. Clin Oral Investig. 2017;21:1277–82.PubMedCrossRef Gokturk H, Bayram E, Bayram HM, Aslan T, Ustun Y. Effect of double antibiotic and calcium hydroxide pastes on dislodgement resistance of an epoxy resin-based and two calcium silicate-based root canal sealers. Clin Oral Investig. 2017;21:1277–82.PubMedCrossRef
40.
go back to reference Trope M, Bunes A, Debelian G. Root filling materials and techniques: bioceramics a new hope? Endod Top. 2015;32:86–96.CrossRef Trope M, Bunes A, Debelian G. Root filling materials and techniques: bioceramics a new hope? Endod Top. 2015;32:86–96.CrossRef
41.
go back to reference Kadic S, Baraba A, Miletic I, Ionescu A, Brambilla E, Malcic AI, Gabric D. Push-out bond strength of three different calcium silicate-based root-end filling materials after ultrasonic retrograde cavity preparation. Clin Oral Investig. 2018;22:1559–65.PubMedCrossRef Kadic S, Baraba A, Miletic I, Ionescu A, Brambilla E, Malcic AI, Gabric D. Push-out bond strength of three different calcium silicate-based root-end filling materials after ultrasonic retrograde cavity preparation. Clin Oral Investig. 2018;22:1559–65.PubMedCrossRef
Metadata
Title
The effect of intracanal medicaments used in Endodontics on the dislocation resistance of two calcium silicate-based filling materials
Authors
Sara Alsubait
Norah Alsaad
Sumayyah Alahmari
Fatimah Alfaraj
Hussam Alfawaz
Abdullah Alqedairi
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
Antibiotic
Published in
BMC Oral Health / Issue 1/2020
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-020-1044-6

Other articles of this Issue 1/2020

BMC Oral Health 1/2020 Go to the issue