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BMC Oral Health
Published in: BMC Oral Health 1/2020

01-12-2020 | Obesity | Research article

Impact of non-surgical periodontal therapy on serum Resistin and periodontal pathogen in periodontitis patients with obesity

Authors: Khairunnisa Md Tahir, Ainul Haliza Ab Malek, Rathna Devi Vaithilingam, Roslan Saub, Syarida Hasnur Safii, Mohammad Tariqur Rahman, Fathilah Abdul Razak, Aied M Alabsi, Nor Adinar Baharuddin

Published in: BMC Oral Health | Issue 1/2020

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Abstract

Background

Non-surgical periodontal therapy (NSPT) known as gold standard treatment in managing periodontitis. The aim of this study was to investigate the response of NSPT in periodontitis subjects who were obese. Clinical parameters of periodontitis, changes in serum resistin and periodontal pathogens in subgingival plaque were compared before and after NSPT in periodontitis subjects who were obese and with normal weight.

Methods

A total of 48 periodontitis subjects (obese, n = 18; normal weight, n = 30) were recruited (hereafter will be referred as participants) to participate into a prospective, before and after clinical trial. Obesity status is defined by body mass index (BMI) criteria (obese: ≥30 kg/ m2; normal weight < 25 kg/m2). Visible Plaque Index (VPI), Gingival Bleeding Index (GBI), Probing Pocket Depth (PPD) and Clinical Attachment Loss (CAL) were recorded; and serum and plaque were collected at baseline and following 12 weeks post-NSPT. Serum resistin level was analyzed using enzyme-linked immune-sorbant assay (ELISA), while detection of periodontal pathogens in dental plaque were carried out using real time PCR (qPCR).

Results

Following NSPT, means VPI and GBI showed significant improvement between obese and normal weight groups (p <  0.05), but no difference in means PPD and CAL was observed between groups. Obesity remained as a predictor for VPI and GBI after adjusting for smoking habit. No significant difference was observed in serum resistin level and mean counts for P. gingivalis, T. forsythia, and P. intermedia between obese and normal weight groups following NSPT.

Conclusions

Regardless of obesity status, NSPT has a significant impact on VPI and GBI in periodontitis subjects. However, the impact of NSPT towards serum resistin and periodontal pathogens was non-significant in those with periodontitis.

Trial registration

This study followed the Consolidation Standards of Reporting Trials Statement and retrospectively registered on 26/11/2015 at clinicaltrials.​gov (No. NCT02618486).
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Metadata
Title
Impact of non-surgical periodontal therapy on serum Resistin and periodontal pathogen in periodontitis patients with obesity
Authors
Khairunnisa Md Tahir
Ainul Haliza Ab Malek
Rathna Devi Vaithilingam
Roslan Saub
Syarida Hasnur Safii
Mohammad Tariqur Rahman
Fathilah Abdul Razak
Aied M Alabsi
Nor Adinar Baharuddin
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2020
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-020-1039-3

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