Skip to main content
Top
Published in: BMC Oral Health 1/2020

01-12-2020 | Doxycycline | Research article

Comparison of antimicrobial prescribing for dental and oral infections in England and Scotland with Norway and Sweden and their relative contribution to national consumption 2010–2016

Authors: Andrew Smith, Rania Al-Mahdi, William Malcolm, Nikolaus Palmer, Gunnar Dahlen, Mohammed Al-Haroni

Published in: BMC Oral Health | Issue 1/2020

Login to get access

Abstract

Background

Prescribing in dental practice has a relatively small but important contribution to the quantity of antibiotics prescribed in primary care. This study aimed to analyse antibiotic prescribing in dentistry over time (2010–2016) in 4 different Northern European countries and their relative contribution to national outpatients consumption.

Methods

This retrospective study evaluated the frequency and number of national antibiotic prescriptions written by dentists in England, Scotland, Norway and Sweden. The consumption of such antibiotics was measured using WHO defined daily doses (DDDs), DDDs per 100,000 inhabitants per day (DIDs100,000).

Results

A total of more than 27 million prescriptions (27,026,599) archived between 2010 and 2016 from the four countries were analysed. The national contribution of Norwegian dentists to the total primary care prescription during this period was 8%. The corresponding figures for Sweden, Scotland and England were 7, 6, and 8%. Dental contribution to National antibiotic use in all four countries has decreased over the study time period for commonly prescribed antibiotics in dentistry, i.e., the beta-lactams (Phenoxymethyl penicillin/Amoxicillin) and metronidazole. There were less numbers of prescriptions by dentists in Norway and Sweden compared to England and Scotland. Marked differences in some classes of antibiotics were noted with Phenoxymethyl penicillin dominating in Sweden/Norway compared to Amoxicillin and Metronidazole in England/Scotland. In England and Scotland, dentists were the largest prescribers of metronidazole in primary care. Clindamycin prescriptions was higher in Norway and Sweden.

Conclusion

Noticeable differences exist in prescribing patterns for the management of oral infections. High levels of metronidazole use in England and Scotland also require further analysis. All countries over the study period showed a decrease in total numbers of antibiotics prescribed.
Literature
1.
go back to reference The Norwegian Directorate of Health. Antibiotic use in Primary Health Services (In Norwegian). 2019. The Norwegian Directorate of Health. Antibiotic use in Primary Health Services (In Norwegian). 2019.
2.
go back to reference The Faculty of General Dental Practitioners UK. Antimicrobial prescribing for general Dental practitioners. 2nd ed; 2014. The Faculty of General Dental Practitioners UK. Antimicrobial prescribing for general Dental practitioners. 2nd ed; 2014.
3.
go back to reference Drug Prescriping For Dentistry. Scottish dental clinical effectiveness Programme. 3rd ed; 2016. Drug Prescriping For Dentistry. Scottish dental clinical effectiveness Programme. 3rd ed; 2016.
4.
go back to reference Cope AL, Chestnutt IG. Inappropriate prescribing of antibiotics in primary dental care: reasons and resolutions. Prim Dent J. 2014;3:33–7.CrossRef Cope AL, Chestnutt IG. Inappropriate prescribing of antibiotics in primary dental care: reasons and resolutions. Prim Dent J. 2014;3:33–7.CrossRef
5.
go back to reference Halboub E, Alzaili A, Quadri MF, Al-Haroni M, Al-Obaida MI, Al-Hebshi NN. Antibiotic prescription knowledge of dentists in Kingdom of Saudi Arabia: an online, Country-wide Survey. J Contemp Dent Pract. 2016;17:198–204.CrossRef Halboub E, Alzaili A, Quadri MF, Al-Haroni M, Al-Obaida MI, Al-Hebshi NN. Antibiotic prescription knowledge of dentists in Kingdom of Saudi Arabia: an online, Country-wide Survey. J Contemp Dent Pract. 2016;17:198–204.CrossRef
6.
go back to reference Al-Haroni M, Skaug N. Knowledge of prescribing antimicrobials among Yemeni general dentists. Acta Odontol Scand. 2006;64:274–80.CrossRef Al-Haroni M, Skaug N. Knowledge of prescribing antimicrobials among Yemeni general dentists. Acta Odontol Scand. 2006;64:274–80.CrossRef
7.
go back to reference Dailey YM, Martin MV. Are antibiotics being used appropriately for emergency dental treatment? Br Dent J. 2001;191:391–3.CrossRef Dailey YM, Martin MV. Are antibiotics being used appropriately for emergency dental treatment? Br Dent J. 2001;191:391–3.CrossRef
8.
go back to reference Palmer NO, Martin MV, Pealing R, Ireland RS. An analysis of antibiotic prescriptions from general dental practitioners in England. J Antimicrob Chemother. 2000;46:1033–5.CrossRef Palmer NO, Martin MV, Pealing R, Ireland RS. An analysis of antibiotic prescriptions from general dental practitioners in England. J Antimicrob Chemother. 2000;46:1033–5.CrossRef
9.
go back to reference Palmer NO, Martin MV, Pealing R, Ireland RS. Paediatric antibiotic prescribing by general dental practitioners in England. Int J Paediatr Dent. 2001;11:242–8.CrossRef Palmer NO, Martin MV, Pealing R, Ireland RS. Paediatric antibiotic prescribing by general dental practitioners in England. Int J Paediatr Dent. 2001;11:242–8.CrossRef
10.
go back to reference Thompson W, Tonkin-Crine S, Pavitt SH, McEachan RRC, Douglas GVA, Aggarwal VR, et al. Factors associated with antibiotic prescribing for adults with acute conditions: an umbrella review across primary care and a systematic review focusing on primary dental care. J Antimicrob Chemother. 2019;74:2139–52.CrossRef Thompson W, Tonkin-Crine S, Pavitt SH, McEachan RRC, Douglas GVA, Aggarwal VR, et al. Factors associated with antibiotic prescribing for adults with acute conditions: an umbrella review across primary care and a systematic review focusing on primary dental care. J Antimicrob Chemother. 2019;74:2139–52.CrossRef
11.
go back to reference Kassebaum NJ, Smith AGC, Bernabe E, Fleming TD, Reynolds AE, Vos T, et al. Global, regional, and National Prevalence, incidence, and disability-adjusted life years for Oral conditions for 195 countries, 1990-2015: A systematic analysis for the global burden of diseases, injuries, and risk factors. J Dent Res. 2017;96:380–7.CrossRef Kassebaum NJ, Smith AGC, Bernabe E, Fleming TD, Reynolds AE, Vos T, et al. Global, regional, and National Prevalence, incidence, and disability-adjusted life years for Oral conditions for 195 countries, 1990-2015: A systematic analysis for the global burden of diseases, injuries, and risk factors. J Dent Res. 2017;96:380–7.CrossRef
12.
go back to reference Robertson D, Smith AJ. The microbiology of the acute dental abscess. J Med Microbiol. 2009;58:155–62.CrossRef Robertson D, Smith AJ. The microbiology of the acute dental abscess. J Med Microbiol. 2009;58:155–62.CrossRef
13.
go back to reference Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD. Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis. BMJ. 2010;340:c2096.CrossRef Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD. Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis. BMJ. 2010;340:c2096.CrossRef
14.
go back to reference Malhotra-Kumar S, Van Heirstraeten L, Coenen S, Lammens C, Adriaenssens N, Kowalczyk A, et al. Impact of amoxicillin therapy on resistance selection in patients with community-acquired lower respiratory tract infections: a randomized, placebo-controlled study. J Antimicrob Chemother. 2016;71:3258–67.CrossRef Malhotra-Kumar S, Van Heirstraeten L, Coenen S, Lammens C, Adriaenssens N, Kowalczyk A, et al. Impact of amoxicillin therapy on resistance selection in patients with community-acquired lower respiratory tract infections: a randomized, placebo-controlled study. J Antimicrob Chemother. 2016;71:3258–67.CrossRef
15.
go back to reference Pouwels KB, Freeman R, Muller-Pebody B, Rooney G, Henderson KL, Robotham JV, et al. Association between use of different antibiotics and trimethoprim resistance: going beyond the obvious crude association. J Antimicrob Chemother. 2018;73:1700–7.CrossRef Pouwels KB, Freeman R, Muller-Pebody B, Rooney G, Henderson KL, Robotham JV, et al. Association between use of different antibiotics and trimethoprim resistance: going beyond the obvious crude association. J Antimicrob Chemother. 2018;73:1700–7.CrossRef
16.
go back to reference Doron S, Davidson LE. Antimicrobial stewardship. Mayo Clin Proc. 2011;86:1113–23.CrossRef Doron S, Davidson LE. Antimicrobial stewardship. Mayo Clin Proc. 2011;86:1113–23.CrossRef
17.
go back to reference Loffler C, Bohmer F. The effect of interventions aiming to optimise the prescription of antibiotics in dental care-A systematic review. PLoS One. 2017;12:e0188061.CrossRef Loffler C, Bohmer F. The effect of interventions aiming to optimise the prescription of antibiotics in dental care-A systematic review. PLoS One. 2017;12:e0188061.CrossRef
18.
go back to reference The Norwegian Institute of Public Health (NIPH). The Norwegian Prescription Database (NorPD). 2018. The Norwegian Institute of Public Health (NIPH). The Norwegian Prescription Database (NorPD). 2018.
19.
go back to reference WHO Collaborating Centre for Drug Statistics Methodology. Norwegian Institute of Public Health, Oslo, Norway. The ATC/DDD system: WHO Collaborating Centre for Drug Statistics Methodology; 2018. WHO Collaborating Centre for Drug Statistics Methodology. Norwegian Institute of Public Health, Oslo, Norway. The ATC/DDD system: WHO Collaborating Centre for Drug Statistics Methodology; 2018.
20.
go back to reference DALYs GBD, Collaborators H, Murray CJ, Barber RM, Foreman KJ, Abbasoglu Ozgoren A, et al. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. Lancet. 2015;386:2145–91.CrossRef DALYs GBD, Collaborators H, Murray CJ, Barber RM, Foreman KJ, Abbasoglu Ozgoren A, et al. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. Lancet. 2015;386:2145–91.CrossRef
21.
go back to reference Burke FJT, Wilson NHF, Brunton PA, Creanor S. Contemporary dental practice in the UK. Part 1: demography and practising arrangements in 2015. Br Dent J. 2019;226:55–61.CrossRef Burke FJT, Wilson NHF, Brunton PA, Creanor S. Contemporary dental practice in the UK. Part 1: demography and practising arrangements in 2015. Br Dent J. 2019;226:55–61.CrossRef
22.
go back to reference Health and Social Care Committee. Report on Antimicrobial Resistance. 11th report of session 2017-2019. London: House of Commons, UK Parlamant; 2018. Health and Social Care Committee. Report on Antimicrobial Resistance. 11th report of session 2017-2019. London: House of Commons, UK Parlamant; 2018.
23.
go back to reference Joint Formulary Committee. British National Formulary. 2018. Joint Formulary Committee. British National Formulary. 2018.
24.
go back to reference Parikka M. Treatment of acute dental infections. Tandläkartidningen. 2019;5:76–81. Parikka M. Treatment of acute dental infections. Tandläkartidningen. 2019;5:76–81.
25.
go back to reference Struyf T, Vandael E, Leroy R, Mertens K, Catry B. Antimicrobial prescribing by Belgian dentists in ambulatory care, from 2010 to 2016. Int Dent J. 2019;69(6):480–7. Struyf T, Vandael E, Leroy R, Mertens K, Catry B. Antimicrobial prescribing by Belgian dentists in ambulatory care, from 2010 to 2016. Int Dent J. 2019;69(6):480–7.
26.
go back to reference Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. 8th ed. Philadelphia, PA: Elsevier/Saunders; 2015. Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. 8th ed. Philadelphia, PA: Elsevier/Saunders; 2015.
27.
go back to reference Barza M, Weinstein L. Penetration of antibiotics into fibrin loci in vivo. I. Comparison of penetration of ampicillin into fibrin clots, abscesses, and "interstitial fluid". J Infect Dis. 1974;129:59–65.CrossRef Barza M, Weinstein L. Penetration of antibiotics into fibrin loci in vivo. I. Comparison of penetration of ampicillin into fibrin clots, abscesses, and "interstitial fluid". J Infect Dis. 1974;129:59–65.CrossRef
28.
go back to reference Rolinson GN, Sutherland R. Semisynthetic penicillins. Adv Pharmacol Chemother. 1973;11:151–220.CrossRef Rolinson GN, Sutherland R. Semisynthetic penicillins. Adv Pharmacol Chemother. 1973;11:151–220.CrossRef
29.
go back to reference Marcy SM, Klein JO. The isoxazolyl penicillins: oxacillin, cloxacillin, and dicloxacillin. Med Clin North Am. 1970;54:1127–43.CrossRef Marcy SM, Klein JO. The isoxazolyl penicillins: oxacillin, cloxacillin, and dicloxacillin. Med Clin North Am. 1970;54:1127–43.CrossRef
30.
go back to reference Efstratiou A. Pyogenic streptococci of Lancefield groups C and G as pathogens in man. J Appl Microbiol. 1997;83:72S–9S.CrossRef Efstratiou A. Pyogenic streptococci of Lancefield groups C and G as pathogens in man. J Appl Microbiol. 1997;83:72S–9S.CrossRef
32.
go back to reference Kuriyama T, Karasawa T, Williams DW, Nakagawa K, Yamamoto E. An increased prevalence of {beta}-lactamase-positive isolates in Japanese patients with dentoalveolar infection. J Antimicrob Chemother. 2006;58:708–9.CrossRef Kuriyama T, Karasawa T, Williams DW, Nakagawa K, Yamamoto E. An increased prevalence of {beta}-lactamase-positive isolates in Japanese patients with dentoalveolar infection. J Antimicrob Chemother. 2006;58:708–9.CrossRef
33.
go back to reference Lewis MA, MacFarlane TW, McGowan DA. Antibiotic susceptibilities of bacteria isolated from acute dentoalveolar abscesses. J Antimicrob Chemother. 1989;23:69–77.CrossRef Lewis MA, MacFarlane TW, McGowan DA. Antibiotic susceptibilities of bacteria isolated from acute dentoalveolar abscesses. J Antimicrob Chemother. 1989;23:69–77.CrossRef
34.
go back to reference Lewis MA, Parkhurst CL, Douglas CW, Martin MV, Absi EG, Bishop PA, et al. Prevalence of penicillin resistant bacteria in acute suppurative oral infection. J Antimicrob Chemother. 1995;35:785–91.CrossRef Lewis MA, Parkhurst CL, Douglas CW, Martin MV, Absi EG, Bishop PA, et al. Prevalence of penicillin resistant bacteria in acute suppurative oral infection. J Antimicrob Chemother. 1995;35:785–91.CrossRef
35.
go back to reference Storoe W, Haug RH, Lillich TT. The changing face of odontogenic infections. J Oral Maxillofac Surg. 2001;59:739–48 discussion 48-9.CrossRef Storoe W, Haug RH, Lillich TT. The changing face of odontogenic infections. J Oral Maxillofac Surg. 2001;59:739–48 discussion 48-9.CrossRef
36.
go back to reference Kuriyama T, Karasawa T, Nakagawa K, Saiki Y, Yamamoto E, Nakamura S. Bacteriologic features and antimicrobial susceptibility in isolates from orofacial odontogenic infections. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:600–8.CrossRef Kuriyama T, Karasawa T, Nakagawa K, Saiki Y, Yamamoto E, Nakamura S. Bacteriologic features and antimicrobial susceptibility in isolates from orofacial odontogenic infections. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:600–8.CrossRef
37.
go back to reference Kuriyama T, Karasawa T, Nakagawa K, Yamamoto E, Nakamura S. Incidence of beta-lactamase production and antimicrobial susceptibility of anaerobic gram-negative rods isolated from pus specimens of orofacial odontogenic infections. Oral Microbiol Immunol. 2001;16:10–5.CrossRef Kuriyama T, Karasawa T, Nakagawa K, Yamamoto E, Nakamura S. Incidence of beta-lactamase production and antimicrobial susceptibility of anaerobic gram-negative rods isolated from pus specimens of orofacial odontogenic infections. Oral Microbiol Immunol. 2001;16:10–5.CrossRef
38.
go back to reference Kuriyama T, Karasawa T, Nakagawa K, Yamamoto E, Nakamura S. Bacteriology and antimicrobial susceptibility of gram-positive cocci isolated from pus specimens of orofacial odontogenic infections. Oral Microbiol Immunol. 2002;17:132–5.CrossRef Kuriyama T, Karasawa T, Nakagawa K, Yamamoto E, Nakamura S. Bacteriology and antimicrobial susceptibility of gram-positive cocci isolated from pus specimens of orofacial odontogenic infections. Oral Microbiol Immunol. 2002;17:132–5.CrossRef
39.
go back to reference Kuriyama T, Absi EG, Williams DW, Lewis MA. An outcome audit of the treatment of acute dentoalveolar infection: impact of penicillin resistance. Br Dent J. 2005;198:759–63 discussion 4; quiz 78.CrossRef Kuriyama T, Absi EG, Williams DW, Lewis MA. An outcome audit of the treatment of acute dentoalveolar infection: impact of penicillin resistance. Br Dent J. 2005;198:759–63 discussion 4; quiz 78.CrossRef
40.
go back to reference NHS Digital. Prescription cost analysis - England,. 2016. NHS Digital. Prescription cost analysis - England,. 2016.
41.
go back to reference Health Protection Scotland. Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2016. 2017. Health Protection Scotland. Scottish One Health Antimicrobial Use and Antimicrobial Resistance in 2016. 2017.
42.
go back to reference Lofmark S, Fang H, Hedberg M, Edlund C. Inducible metronidazole resistance and nim genes in clinical Bacteroides fragilis group isolates. Antimicrob Agents Chemother. 2005;49:1253–6.CrossRef Lofmark S, Fang H, Hedberg M, Edlund C. Inducible metronidazole resistance and nim genes in clinical Bacteroides fragilis group isolates. Antimicrob Agents Chemother. 2005;49:1253–6.CrossRef
Metadata
Title
Comparison of antimicrobial prescribing for dental and oral infections in England and Scotland with Norway and Sweden and their relative contribution to national consumption 2010–2016
Authors
Andrew Smith
Rania Al-Mahdi
William Malcolm
Nikolaus Palmer
Gunnar Dahlen
Mohammed Al-Haroni
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2020
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-020-01163-x

Other articles of this Issue 1/2020

BMC Oral Health 1/2020 Go to the issue