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BMC Oral Health

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Open Access 01-12-2018 | Research article

IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis

Authors: Wenbo Zhang, Pu Xu, Zhuogeng Chen, Yanan Cheng, Xiaoni Li, Qiuhua Mao

Published in: BMC Oral Health | Issue 1/2018

Abstract

Background

Several studies have examined the association between the IL-13 -1112C/T polymorphism and the risk of periodontitis. However, these studies have reached different conclusions. The aim of the current study was to investigate the link between this IL-13 -1112 polymorphism and susceptibility to periodontitis.

Methods

We utilized electronic databases, including the CNKI (China National Knowledge Infrastructure), Wanfang, PubMed, Embase, and Cochrane Library databases, to manually search for relevant research published through November 30, 2016. The Chinese and English terms used to search the literature included “periodontitis”, “periodontal disease”, “IL 13”, “IL-13”, and “interleukin-13”. In accordance with our inclusion criteria, we selected studies that involved case-control trials. All of these case-control trials described their objectives, design and specific statistical methods. For all included studies, odds ratios (ORs) and 95% confidence intervals (95% CIs) were provided or could be calculated from the study data. The quality of the included literature was evaluated using the Newcastle-Ottawa scale (NOS). STATA 12.0 was used to calculate the sizes of the combined effects and conduct a sensitivity analysis of the results.

Results

Our meta-analysis included 4 articles representing 5 case-control studies with a total of 710 cases and 671 control subjects. The meta-analysis results indicated that the CC vs TT model, CT vs TT model and TT vs CT + CC model (CC VS TT: OR = 0.615, 95% CI = 0.395–0.957; CT vs TT: OR = 0.518, 95% CI = 0.323–0.830; and TT vs CT + CC: OR = 1.739, 95% CI = 1.130–2.676) were significant in five IL-13 -1112 gene polymorphism and periodontitis susceptibility models. Subgroup analysis indicated that the CC vs TT, CT vs TT and TT vs CT + CC models were significant in the chronic periodontitis (CP) group, whereas no significant differences were found in the five aggressive periodontitis (AgP) group models. The sensitivity analysis showed that dropping any single study did not affect the pooled analysis results.

Conclusion

The IL-13 -1112 polymorphism may be associated with susceptibility to periodontitis. The IL-13 -1112 gene polymorphism may be associated with susceptibility to CP but not to AgP. Thus, large-scale, multi-ethnic case-control trials are still warranted.

Armitage GC. Development of a classification system for periodontal diseases and conditions. Northwest Dent. 2000;79:31–5.PubMed

Wei XM, Chen YJ, Wu L, Cui LJ, Hu DW, Zeng XT. Tumor necrosis factor-alpha G-308A (rs1800629) polymorphism and aggressive periodontitis susceptibility: a meta-analysis of 16 case-control studies. Sci Rep. 2016;6:19099.CrossRefPubMedPubMedCentral

Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014;93:1045–53.CrossRefPubMedPubMedCentral

Albuquerque CM, Cortinhas AJ, Morinha FJ, Leitão JC, Viegas CA, Bastos EM. Association of the IL-10 polymorphisma and periodontitis: a meta-analysis. Mol Biol Rep. 2012;39:9319–29.CrossRefPubMed

Trevilatto PC, de Souza Pardo AP, Scarel-Caminaga RM, de Brito RB Jr, Alvim-Pereira F, Alvim-Pereira CC, Probst CM, Garlet GP, Sallum AW, Line SR. Association of IL1 gene polymorphisms with chronic periodontitis in Brazilians. Arch Oral Biol. 2011;56:54–62.CrossRefPubMed

Saraiva AM, Alves e Silva MR, Correia Silva Jde F, da Costa JE, Gollob KJ, Dutra WO, Moreira PR. Evaluation of IL17A expression and of IL17A expression and of IL17A, IL17F and IL23R gene polymorphisms in Brazilian individuals with periodontitis. Hum Immunol. 2013;74:207–14.CrossRefPubMed

Graves PE, Kabesch M, Halonen M, Holberg CJ, Baldini M, Fritzsch C, et al. Acluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. Allergy. Clin Immunol. 2000;105:506–13.

Weng H, Yan Y, Jin YH, Meng XY, Mo YY, Zeng XT. Matrix metalloproteinase genepolymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals. PLoS One. 2016; https://doi.org/10.1038/srep24812.

Zeng X, Zhang Y, Kwong JS. Etal. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysisi, and clinical practice guideline: a systematic review. J Evid Based Med. 2015;8:2–10.CrossRefPubMed

10.

Gonzales JR, Mann M, Stelzig J, Bödeker RH, Meyle J. Single nucleotide polymorphisms in the IL-4 and IL-13 promoter region in aggressive periodontitis. J Clin periodontal. 2007;34:473–9.CrossRef

11.

Wu YM, Chuang HL, Ho YP, Ho KY, Tsai CC. Investigation of interleukin-13 gene polymorphisms in individuals with chronic and generalized aggressive periodontitis in a Taiwanese (Chinese) population. J Periodontal Res. 2010;45:695–701.CrossRefPubMed

12.

Zhang YJ, Lu W, Huang YH, et al. Study on the association between interleukin-13 gene -1112C/T polymorphism and chronic periodontitis. J Dental Prev Treat. 2010;20:233–6.

13.

Chen D, Wang LM, Zhang J, et al. Study on IL-13 and IL-4 gene polymorphisms and linkage disequilibrium in chronic periodontitis of Han nationality. J Shanghai Jiaotong Univ. 2013;33:796–800.

14.

Feres M, Figueiredo LC. Current concepts in the microbial etiology and treatment of chornicperidontitis. J IntAcad Periodonontol. 2009;11:234–49.

15.

Kamei H, Ishihara Y, Noguchi T. Searches for the genes associated with periodontitis with gene polymorphisms. Clin Calcium. 2006;16:305–10.PubMed

16.

Kobayashi T, Murasawa A, Ito S, Yamamoto K, Komatsu Y, Abe A, et al. Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults. J Periodontol. 2009;80:792–79.CrossRefPubMed

17.

Minty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, et al. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature. 1993;362:248–50.CrossRefPubMed

18.

Wynn TA. IL-13 effector functions. Annu Rev Immunol. 2003;21:425–56.CrossRefPubMed

19.

Mckenzie AN, Culpepper JA, de Waal MR, Brière F, Punnonen J, Aversa G, et al. Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function. Proc Natl Acad Sci U S A. 1993;90:3735–9.CrossRefPubMedPubMedCentral

20.

Mentink-Kane MM, Cheever AW, Thompson RW, Hari DM, Kabatereine NB, Vennervald BJ, et al. IL-13 receptor α2 downmodulates granulomatous inflammation and prolongs host survival in schistosomiasis. Proc Natl Acad Sci U S A. 2004;101:586–90.CrossRefPubMed

21.

Wood N, Whitters MJ, Jacobson BA, Witek J, Sypek JP, Kasaian M, et al. Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor α2. Exp Med. 2003;197:703–9.CrossRef

22.

Jakubzick C, Choi ES, Kunkel SL, Joshi BH, Puri RK, Hogaboam CM. Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of TH1- and TH2-type pulmonary granuloma fibroblasts. Am J Pathol. 2003;162:1475–86.CrossRefPubMedPubMedCentral

23.

Barnes KC. Evidence for common genetic elements in allergic disease. J Allergy Clin Immunol. 2000;106:S192–200.CrossRefPubMed

24.

Nie W, Liu Y, Bian J, Li B, Xiu Q. Effects of polymorphisms -1112C/T and+2044A/G in Interleukin-13 gene on asthma risk: a meta-analysis. PLoS One. 2013;8:e56065.CrossRefPubMedPubMedCentral

25.

Alsaid A, El-Missiry M, Hatata E-S, Tarabay M, Settin A. Association of IL-4-590C>T and IL-13-1112 C>T gene polymorphisms with the susceptibility to type 2 diabetes mellitus. Dis Markers. 2013;35:243–7.CrossRefPubMedPubMedCentral

26.

Chen L, Shen Y, Liu L, Li X, Wang T, Wen F. Interleukin-13 -1112 C/T promoter polymorphism confers risk for COPD: a meta-analysis. PLoS One. 2013;8:e68222.CrossRefPubMedPubMedCentral

27.

Borrell LN, Papapanou PN. Analytical epidemiology of periodontitis. J Clin Periodontol. 2005;32:132–58.CrossRefPubMed

28.

Oxman AD. Systematic reviews: checklists for review articles. Br Med J. 1994;309:648–51.CrossRef

29.

Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Br Med J. 1997;315:629–34.CrossRef

30.

Light RJ, Pillemer DB. Quantitative procedures. Suming up: the science of reviewing research. 1984;

31.

Begg CB, Mazumdar M. Operating characteristic of rank correlation test for publication bias. Biometrics. 1994;50:1088–101.CrossRefPubMed

32.

Taylor SJ, Tweedie RI. Practical estimates of the effect of publicationbias in meta- analysis. Austr Epidemiol. 1998;5:14–7.

33.

Wang JL. Clinical epidemiology-clinical scientific research design, measurement and evaluation. Shanghai: Shanghai Science and Technology Press; 2001.

34.

Jonathan AC, Sterne ME, Smith GD. Systematic review in health care: investigating and dealing with publication and other bias in meta- analysis. Br Med J. 2001;323:101–5.CrossRef

35.

Egger M, Smith GD. Meta- analysis bias in location and selection of studies. Br Med J. 1998;316:61–6.CrossRef

Title: IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis
Authors: Wenbo Zhang
Pu Xu
Zhuogeng Chen
Yanan Cheng
Xiaoni Li
Qiuhua Mao
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Oral Health / Issue 1/2018
Electronic ISSN: 1472-6831
DOI: https://doi.org/10.1186/s12903-018-0481-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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