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BMC Oral Health
Published in: BMC Oral Health 1/2017

Open Access 01-12-2017 | Research article

The Candida species that are important for the development of atrophic glossitis in xerostomia patients

Authors: Sachika Nakamura, Mariko R. Okamoto, Ken Yamamoto, Akihisa Tsurumoto, Yoko Yoshino, Hiroshi Iwabuchi, Ichiro Saito, Nobuko Maeda, Yoichi Nakagawa

Published in: BMC Oral Health | Issue 1/2017

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Abstract

Background

The purpose of this study was to clarify the species of Candida that are important for the development of atrophic glossitis in xerostomia patients.

Methods

A total of 231 patients with subjective dry mouth were enrolled in the present study. Logistic regression analysis was performed to clarify the contribution of each Candida species and other variables to the development of atrophic glossitis. The dependent variable was the absence/presence of atrophic glossitis. The Candida colony-forming units (CFU) of C. albicans, C. glabrata, C. tropicalis, and C. krusei, as well as age, gender, resting (RSFR) and stimulated (SSFR) whole salivary flow rate, and denture-wearing status, were treated as explanatory variables.

Results

Logistic regression analysis showed that two factors were closely associated with the presence of atrophic glossitis: an increase in C. albicans CFU and a decrease in the SSFR.

Conclusions

C. albicans, but not non-albicans Candida, was associated with atrophic glossitis in xerostomia patients who had no systemic predisposing factors, indicating that C. albicans remains a treatment target for Candida-related atrophic glossitis.
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Metadata
Title
The Candida species that are important for the development of atrophic glossitis in xerostomia patients
Authors
Sachika Nakamura
Mariko R. Okamoto
Ken Yamamoto
Akihisa Tsurumoto
Yoko Yoshino
Hiroshi Iwabuchi
Ichiro Saito
Nobuko Maeda
Yoichi Nakagawa
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2017
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-017-0449-3

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