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BMC Oral Health
Published in: BMC Oral Health 1/2015

Open Access 01-12-2015 | Research article

Physical properties and biocompatibility of an injectable calcium-silicate-based root canal sealer: in vitro and in vivo study

Authors: Eun-Su Lim, Young-Bae Park, Young-Sun Kwon, Won-Jun Shon, Kwang-Won Lee, Kyung-San Min

Published in: BMC Oral Health | Issue 1/2015

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Abstract

Background

The aim of this study was to investigate the physical properties and biological effects of an experimentally developed injectable premixed calcium-silicate root canal sealer (Endoseal) in comparison with mineral trioxide aggregate (MTA) and a resin-based sealer (AHplus).

Methods

The pH, solubility, dimensional change, flow, and radiopacity of the materials were evaluated. Biocompatibility was evaluated on the basis of cell morphology and a viability test using MC3T3-E1 cells. For evaluate inflammatory reaction, the tested sealers were implanted into dorsal subcutaneous connective tissue of Sprague Dawley rats. After 7 days, the implants with the surrounding tissue were retrieved, and histological evaluation was performed.

Results

Endoseal showed high alkalinity similar to that of MTA. The solubility of the tested materials was similar. The dimensional change and flow of Endoseal was significantly higher than that of other materials (P < 0.05). The radiopacity of Endoseal was lower than that of AHplus (P < 0.05). The biocompatibility was similar to those of MTA. Inflammatory reaction of Endoseal was similar with that of MTA, but lower than that of AHplus (P < 0.05).

Conclusions

The present study indicates that Endoseal has favorable physical properties and biocompatibility. Therefore, we suggest that Endoseal has the potential to be used as a predictable root canal sealer.
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Metadata
Title
Physical properties and biocompatibility of an injectable calcium-silicate-based root canal sealer: in vitro and in vivo study
Authors
Eun-Su Lim
Young-Bae Park
Young-Sun Kwon
Won-Jun Shon
Kwang-Won Lee
Kyung-San Min
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2015
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-015-0112-9

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