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BMC Oral Health
Published in: BMC Oral Health 1/2015

Open Access 01-12-2015 | Research article

Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma

Authors: Oddveig G. Rikardsen, Synnøve N. Magnussen, Gunbjørg Svineng, Elin Hadler-Olsen, Lars Uhlin-Hansen, Sonja E. Steigen

Published in: BMC Oral Health | Issue 1/2015

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Abstract

Background

Oral squamous cell carcinoma (OSCC) is associated with a poor 5-year survival rate. In general, patients diagnosed with small tumors have a fairly good prognosis, but some small tumors have an aggressive behavior leading to early death. There are at present no reliable prognostic biomarkers for oral cancers. Thus, to optimize treatment for the individual patient, there is a need for biomarkers that can predict tumor behavior.

Method

In the present study the potential prognostic value of plectin was evaluated by a tissue microarray (TMA) based immunohistochemical analysis of primary tumor tissue obtained from a North Norwegian cohort of 115 patients diagnosed with OSCC. The expression of plectin was compared with clinicopathological variables and 5 year survival.

Results

The statistical analysis revealed that low expression of plectin in the tumor cells predicted a favorable outcome for patients with non-metastatic disease (p = 0.008). Furthermore, the expression of plectin was found to correlate (p = 0.01) with the expression of uPAR, which we have previously found to be a potential prognostic marker for T1N0 tumors.

Conclusions

Our results indicate that low expression of plectin predicts a favorable outcome for patients with non-metastatic OSCC and the expression level of plectin may therefore be used in the treatment stratification for patients with early stage disease.
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Metadata
Title
Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
Authors
Oddveig G. Rikardsen
Synnøve N. Magnussen
Gunbjørg Svineng
Elin Hadler-Olsen
Lars Uhlin-Hansen
Sonja E. Steigen
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2015
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-015-0084-9

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