Skip to main content
Top
Published in: BMC Urology 1/2021

Open Access 01-12-2021 | Benign Prostatic Hypertrophy | Research article

Holmium laser enucleation of the prostate with Virtual Basket mode: faster and better control on bleeding

Authors: Giorgio Bozzini, Matteo Maltagliati, Umberto Besana, Lorenzo Berti, Albert Calori, Maria Chiara Sighinolfi, Salvatore Micali, Jean Baptiste Roche, Ali Gozen, Alexander Mueller, Dimitry Pushkar, Evangelos Liatsikos, Marco Boldini, Carlo Buizza, Bernardo Rocco

Published in: BMC Urology | Issue 1/2021

Login to get access

Abstract

Background

To compare clinical intra and early postoperative outcomes between conventional Holmium laser enucleation of the prostate (HoLEP) and Holmium laser enucleation of the prostate using the Virtual Basket tool (VB-HoLEP) to treat benign prostatic hyperplasia (BPH).

Methods

This prospective randomized study enrolled consecutive patients with BPH, who were assigned to undergo either HoLEP (n = 100), or VB-HoLEP (n = 100). All patients were evaluated preoperatively and postoperatively, with particular attention to catheterization time, operative time, blood loss, irrigation volume and hospital stay. We also evaluated the patients at 3 and 6 months after surgery and assessed maximum flow rate (Qmax), postvoid residual urine volume (PVR), the International Prostate Symptom Score (IPSS) and the Quality of Life score (QOLS).

Results

No significant differences in preoperative parameters between patients in each study arm were found. Compared to HoLEP, VB-HoLEP resulted in less hemoglobin decrease (2.54 vs. 1.12 g/dl, P = 0.03) and reduced operative time (57.33 ± 29.71 vs. 42.99 ± 18.51 min, P = 0.04). HoLEP and VB-HoLEP detrmined similar catheterization time (2.2 vs. 1.9 days, P = 0.45), irrigation volume (33.3 vs. 31.7 l, P = 0.69), and hospital stay (2.8 vs. 2.7 days, P = 0.21). During the 6-month follow-up no significant differences in IPSS, Qmax, PVR, and QOLS were demonstrated.

Conclusions

HoLEP and VB-HoLEP are both efficient and safe procedures for relieving lower urinary tract symptoms. VB-HoLEP was statistically superior to HoLEP in blood loss and operative time. However, procedures did not differ significantly in catheterization time, hospital stay, and irrigation volume. No significant differences were demonstrated in QOLS, IPSS, Qmax and PVR throughout the 6-month follow-up.
Trial Registration: Current Controlled Trials ISRCTN72879639; date of registration: June 25th, 2015. Retrospectively registred.
Literature
1.
go back to reference Gravas S, et al. EAU guidelines of management of non-neurogenic male lower urinary tract symptoms (LUTS), incl. Benign Prostatic Obstruction (BPO), EAU Guidelines; 2019. Gravas S, et al. EAU guidelines of management of non-neurogenic male lower urinary tract symptoms (LUTS), incl. Benign Prostatic Obstruction (BPO), EAU Guidelines; 2019.
2.
go back to reference Leonardo C, Lombardo R, Cindolo L. What is the standard surgical approach to large volume BPE? Systematic review of existing randomized clinical trials. Minerva Urol Nefrol. 2020;72(1):22–9.CrossRef Leonardo C, Lombardo R, Cindolo L. What is the standard surgical approach to large volume BPE? Systematic review of existing randomized clinical trials. Minerva Urol Nefrol. 2020;72(1):22–9.CrossRef
3.
go back to reference Herrmann Thomas RW, Bach T. Thulium laser enucleation of the prostate (ThuLEP): transurethral anatomical prostatectomy with laser support. Introduction of a novel technique for the treatment of benign prostatic obstruction. World J Urol. 2010;28:45–51.CrossRef Herrmann Thomas RW, Bach T. Thulium laser enucleation of the prostate (ThuLEP): transurethral anatomical prostatectomy with laser support. Introduction of a novel technique for the treatment of benign prostatic obstruction. World J Urol. 2010;28:45–51.CrossRef
4.
go back to reference Nguyen DD, Misraï V, Bach T. Operative time comparison of aquablation, greenlight PVP, ThuLEP, GreenLEP, and HoLEP. World J Urol. 2020;38:3227–33.CrossRef Nguyen DD, Misraï V, Bach T. Operative time comparison of aquablation, greenlight PVP, ThuLEP, GreenLEP, and HoLEP. World J Urol. 2020;38:3227–33.CrossRef
5.
go back to reference Fraundorfer MR, Gilling PJ. Holmium:YAG laser enucleation of the prostate combined with mechanical morcellation: preliminary results. Eur Urol. 1998;33(1):69–72.CrossRef Fraundorfer MR, Gilling PJ. Holmium:YAG laser enucleation of the prostate combined with mechanical morcellation: preliminary results. Eur Urol. 1998;33(1):69–72.CrossRef
6.
go back to reference Cornu JN, Ahyai S, Bachmann A, et al. A systematic review and meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic obstruction: an update. Eur Urol. 2015;67(6):1066–96.CrossRef Cornu JN, Ahyai S, Bachmann A, et al. A systematic review and meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic obstruction: an update. Eur Urol. 2015;67(6):1066–96.CrossRef
7.
go back to reference Tooher R, Sutherland P, Costello A, et al. A systematic review of holmium laser prostatectomy for benign prostatic hyperplasia. J Urol. 2004;171(5):1773–81.CrossRef Tooher R, Sutherland P, Costello A, et al. A systematic review of holmium laser prostatectomy for benign prostatic hyperplasia. J Urol. 2004;171(5):1773–81.CrossRef
8.
go back to reference Gilling PJ, Cass CB, Malcolm AR, et al. Combination holmium and Nd:YAG laser ablation of the prostate: initial clinical experience. J Endourol. 1995;9(2):151–3.CrossRef Gilling PJ, Cass CB, Malcolm AR, et al. Combination holmium and Nd:YAG laser ablation of the prostate: initial clinical experience. J Endourol. 1995;9(2):151–3.CrossRef
9.
go back to reference Vizziello D, Acquati P, Clementi M, et al. Virtual Basket technology-impact on high frequency lithotripsy in a urological simulator. J Endourol. 2018;32:A277. Vizziello D, Acquati P, Clementi M, et al. Virtual Basket technology-impact on high frequency lithotripsy in a urological simulator. J Endourol. 2018;32:A277.
10.
go back to reference Bozzini G, Besana U, Maltagliati M, et al. “VirtualBasket” ureteroscopic Holmium laser lithotripsy: intraoperative and early postoperative outcomes. J Urol. 2020;203:e464.CrossRef Bozzini G, Besana U, Maltagliati M, et al. “VirtualBasket” ureteroscopic Holmium laser lithotripsy: intraoperative and early postoperative outcomes. J Urol. 2020;203:e464.CrossRef
11.
go back to reference Davydov DS, Tsarichenko DG, Bezrukov E, et al. Complications of the holmium laser enucleation of prostate for benign prostatic hyperplasia. Urologia. 2018;1:42–7.CrossRef Davydov DS, Tsarichenko DG, Bezrukov E, et al. Complications of the holmium laser enucleation of prostate for benign prostatic hyperplasia. Urologia. 2018;1:42–7.CrossRef
12.
go back to reference Elzayat E, Habib E, Elhilali M. Holmium laser enucleation of the prostate in patients on anticoagulant therapy or with bleeding disorders. J Urol. 2006;175:1428–32.CrossRef Elzayat E, Habib E, Elhilali M. Holmium laser enucleation of the prostate in patients on anticoagulant therapy or with bleeding disorders. J Urol. 2006;175:1428–32.CrossRef
13.
go back to reference Sun J, Shi A, Tong Z, et al. Safety and feasibility study of holmium laser enucleation of the prostate (HOLEP) on patients receiving dual antiplatelet therapy (DAPT). World J Urol. 2018;36(2):271–6.CrossRef Sun J, Shi A, Tong Z, et al. Safety and feasibility study of holmium laser enucleation of the prostate (HOLEP) on patients receiving dual antiplatelet therapy (DAPT). World J Urol. 2018;36(2):271–6.CrossRef
14.
go back to reference Elmansy HM, Kotb A, Elhilali MM. Is there a way to predict stress urinary incontinence after holmium laser enucleation of the prostate? J Urol. 2011;186:1977–81.CrossRef Elmansy HM, Kotb A, Elhilali MM. Is there a way to predict stress urinary incontinence after holmium laser enucleation of the prostate? J Urol. 2011;186:1977–81.CrossRef
15.
go back to reference Montorsi F, Naspro R, Salonia A, et al. Holmium laser enucleation versus transurethral resection of the prostate: results from a 2-center, prospective, randomized trial in patients with obstructive benign prostatic hyperplasia. J Urol. 2004;172(5 Pt 1):1926–9.CrossRef Montorsi F, Naspro R, Salonia A, et al. Holmium laser enucleation versus transurethral resection of the prostate: results from a 2-center, prospective, randomized trial in patients with obstructive benign prostatic hyperplasia. J Urol. 2004;172(5 Pt 1):1926–9.CrossRef
16.
go back to reference Shah HN, Mahajan AP, Hegde SS, et al. Peri-operative complications of holmium laser enucleation of the prostate: experience in the first 280 patients, and a review of literature. BJU Int. 2007;100:94–101.CrossRef Shah HN, Mahajan AP, Hegde SS, et al. Peri-operative complications of holmium laser enucleation of the prostate: experience in the first 280 patients, and a review of literature. BJU Int. 2007;100:94–101.CrossRef
17.
go back to reference Kampantais S, Dimopoulos P, Tasleem A, et al. Assessing the learning curve of holmium laser enucleation of prostate (HoLEP). A systematic review. Urology. 2018;120:9–22.CrossRef Kampantais S, Dimopoulos P, Tasleem A, et al. Assessing the learning curve of holmium laser enucleation of prostate (HoLEP). A systematic review. Urology. 2018;120:9–22.CrossRef
18.
go back to reference Elshal AM, El-Nahas AR, Ghazy M, et al. Low-power vs. high-power holmium laser enucleation of the prostate: critical assessment through randomized trial. Urology. 2018;121:58–65.CrossRef Elshal AM, El-Nahas AR, Ghazy M, et al. Low-power vs. high-power holmium laser enucleation of the prostate: critical assessment through randomized trial. Urology. 2018;121:58–65.CrossRef
19.
go back to reference Becker B, Gross AJ, Netsch C. Safety and efficacy using a low-powered holmium laser for enucleation of the prostate (HoLEP): 12-month results from a prospective low-power HoLEP series. World J Urol. 2018;36(3):441–7.CrossRef Becker B, Gross AJ, Netsch C. Safety and efficacy using a low-powered holmium laser for enucleation of the prostate (HoLEP): 12-month results from a prospective low-power HoLEP series. World J Urol. 2018;36(3):441–7.CrossRef
20.
go back to reference Mullerad M, Aguinaga JRA, Aro T, et al. Initial clinical experience with a modulated holmium laser pulse-moses technology: Does it enhance laser lithotripsy efficacy? Rambam Maimonides Med J. 2017;8(4):e0038.CrossRef Mullerad M, Aguinaga JRA, Aro T, et al. Initial clinical experience with a modulated holmium laser pulse-moses technology: Does it enhance laser lithotripsy efficacy? Rambam Maimonides Med J. 2017;8(4):e0038.CrossRef
21.
go back to reference Terry RS, Whelan PS, Lipkin ME. New devices for kidney stone management. Curr Opin Urol. 2020;30(2):144–8.CrossRef Terry RS, Whelan PS, Lipkin ME. New devices for kidney stone management. Curr Opin Urol. 2020;30(2):144–8.CrossRef
22.
go back to reference Large T, Nottingham C, Stoughton C, et al. Comparative study of holmium laser enucleation of the prostate with MOSES enabled pulsed laser modulation. Urology. 2020;136:196–201.CrossRef Large T, Nottingham C, Stoughton C, et al. Comparative study of holmium laser enucleation of the prostate with MOSES enabled pulsed laser modulation. Urology. 2020;136:196–201.CrossRef
23.
go back to reference Bozzini G, Seveso M, Melegari S, et al. Thulium laser enucleation (ThuLEP) versus transurethral resection of the prostate in saline (TURis): a randomized prospective trial to compare intra and early postoperative outcomes. Actas Urol Esp. 2017;41(5):309–15.CrossRef Bozzini G, Seveso M, Melegari S, et al. Thulium laser enucleation (ThuLEP) versus transurethral resection of the prostate in saline (TURis): a randomized prospective trial to compare intra and early postoperative outcomes. Actas Urol Esp. 2017;41(5):309–15.CrossRef
Metadata
Title
Holmium laser enucleation of the prostate with Virtual Basket mode: faster and better control on bleeding
Authors
Giorgio Bozzini
Matteo Maltagliati
Umberto Besana
Lorenzo Berti
Albert Calori
Maria Chiara Sighinolfi
Salvatore Micali
Jean Baptiste Roche
Ali Gozen
Alexander Mueller
Dimitry Pushkar
Evangelos Liatsikos
Marco Boldini
Carlo Buizza
Bernardo Rocco
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2021
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/s12894-021-00797-5

Other articles of this Issue 1/2021

BMC Urology 1/2021 Go to the issue