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BMC Urology
Published in: BMC Urology 1/2017

Open Access 01-12-2017 | Research article

Ureteral reconstruction using a tapered non-vascularized bladder graft: an experimental study in a canine animal model

Authors: Lujia Zou, Shanhua Mao, Shenghua Liu, Limin Zhang, Tian Yang, Yun Hu, Qiang Ding, Haowen Jiang

Published in: BMC Urology | Issue 1/2017

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Abstract

Background

Reconstruction of ureteral defects and strictures remains problematic for urologists. We aimed to investigate the possibility of a tapered non-vascularized bladder graft as a novel substitute for ureteral reconstruction.

Methods

This experimental study was conducted on nine beagles. Under general anesthesia, a full-thickness graft with 5–6 cm in length was disassociated from the anterior upper wall of the bladder, and tapered into 1/3 to 1/2 thickness, remaining the urothelial surface. After removal of 5 cm of right-sided mid-ureter, the tapered bladder graft was tubularized along the long axis and then respectively anastomosed to the upper and lower stumps of the ureter. A retrograde urography through a cystostomy was performed 8 weeks after the ureteral reconstruction. The animals were euthanized, and histopathologic examinations of the neoureters were performed.

Results

There were no severe complications during postoperative follow-up. The urography indicated patent urine excretion and no fistula or stenosis. Histopathologic examinations of the neoureters showed open lumen with urothelial lining. Nutrient vessels were observed in healthy submucosa, lamina muscularis and peripheral connective tissue.

Conclusions

Our study implied that ureteral reconstruction by a tapered non-vascularized bladder graft was anatomically possible in our animal model. Further studies are expected to confirm long-term and functional outcomes.
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Metadata
Title
Ureteral reconstruction using a tapered non-vascularized bladder graft: an experimental study in a canine animal model
Authors
Lujia Zou
Shanhua Mao
Shenghua Liu
Limin Zhang
Tian Yang
Yun Hu
Qiang Ding
Haowen Jiang
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2017
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/s12894-017-0287-2

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