Skip to main content
Top
Published in: BMC Surgery 1/2019

Open Access 01-12-2019 | Wound Dehiscence | Research article

Abdominal wall complications following renal transplantation in adult recipients – factors associated with interventional management in one unit

Authors: Ngee-Soon Lau, Nima Ahmadi, Deborah Verran

Published in: BMC Surgery | Issue 1/2019

Login to get access

Abstract

Background

Abdominal wall surgical site complications following renal transplantation can be challenging to manage. A sub-group of these recipients will require operative management or advanced wound care such as negative pressure wound therapy (NPWT). The aim of this study was to determine if there were any preoperative, intraoperative and postoperative characteristics in our recipients’ cohort which were associated with the requirement for such interventions.

Methods

A retrospective review of medical records was performed for all recipients who sustained abdominal wall complications following renal transplantation at our centre from 2006 to 2016.

Results

A total of 64/828 recipients (7.7%) had abdominal wall complications. The mean weight for these patients was 84.9 kg (±16.6 kg) and the mean body mass index was 30.2 (±5.1). Forty-five recipients (70%) had a superficial wound dehiscence while nine (14%) had a complete fascial dehiscence. Operative intervention was required in 13/64 patients (20%) and was more likely to be required in the presence of a fascial dehiscence (9/9, 100%) or a wound collection (10/31, 32%) (p < 0.001, p = 0.021). NPWT was used in 17/64 patients (27%) and was more commonly required in patients with diabetes mellitus (10/24, 42%), a complete fascial dehiscence (5/9, 56%) or evidence of infection (16/44, 36%) (p = 0.039, p = 0.034, p = 0.008).

Conclusions

The requirement for either operative management or the use of NPWT in the management of abdominal wall complications following renal transplantation in our experience was more common in recipients with diabetes mellitus, and in the setting of either complete fascial dehiscence, abdominal wall wound collections and/ or infection.
Literature
1.
go back to reference Hernández D, Rufino M, Armas S, González A, Gutiérrez P, Barbero P, et al. Retrospective analysis of surgical complications following cadaveric kidney transplantation in the modern transplant era. Nephrology Dialysis Transplantation. 2006;21(10):2908–15.CrossRef Hernández D, Rufino M, Armas S, González A, Gutiérrez P, Barbero P, et al. Retrospective analysis of surgical complications following cadaveric kidney transplantation in the modern transplant era. Nephrology Dialysis Transplantation. 2006;21(10):2908–15.CrossRef
2.
go back to reference Santangelo M, Clemente M, Spiezia S, Grassia S, Di Capua F, La Tessa C, et al. Wound complications after kidney transplantation in nondiabetic patients. Transplant Proc. 2009;41(4):1221–3.PubMedCrossRef Santangelo M, Clemente M, Spiezia S, Grassia S, Di Capua F, La Tessa C, et al. Wound complications after kidney transplantation in nondiabetic patients. Transplant Proc. 2009;41(4):1221–3.PubMedCrossRef
3.
go back to reference Røine E, Bjørk I, Øyen O. Targeting risk factors for impaired wound healing and wound complications after kidney transplantation. Transplant Proc. 2010;42(7):2542–6.PubMedCrossRef Røine E, Bjørk I, Øyen O. Targeting risk factors for impaired wound healing and wound complications after kidney transplantation. Transplant Proc. 2010;42(7):2542–6.PubMedCrossRef
4.
go back to reference Barba J, Algarra R, Romero L, Tienza A, Velis JM, Robles JE, et al. Recipient and donor risk factors for surgical complications following kidney transplantation. Scandinavian journal of urology. 2013;47(1):63–71.PubMedCrossRef Barba J, Algarra R, Romero L, Tienza A, Velis JM, Robles JE, et al. Recipient and donor risk factors for surgical complications following kidney transplantation. Scandinavian journal of urology. 2013;47(1):63–71.PubMedCrossRef
5.
go back to reference Fockens MM, Alberts VP, Bemelman FJ, van der Pant KA, Idu MM. Wound morbidity after kidney transplant. Prog Transplant. 2015;25(1):45–8.PubMedCrossRef Fockens MM, Alberts VP, Bemelman FJ, van der Pant KA, Idu MM. Wound morbidity after kidney transplant. Prog Transplant. 2015;25(1):45–8.PubMedCrossRef
6.
go back to reference Mehrabi A, Fonouni H, Wente M, Sadeghi M, Eisenbach C, Encke J, et al. Wound complications following kidney and liver transplantation. Clin Transpl. 2006;20(s17):97–110.CrossRef Mehrabi A, Fonouni H, Wente M, Sadeghi M, Eisenbach C, Encke J, et al. Wound complications following kidney and liver transplantation. Clin Transpl. 2006;20(s17):97–110.CrossRef
7.
go back to reference Argenta LC, Morykwas MJ, Marks MW, DeFranzo AJ, Molnar JA, David LR. Vacuum-assisted closure: state of clinic art. Plast Reconstr Surg. 2006;117(7S):127S–42S.PubMedCrossRef Argenta LC, Morykwas MJ, Marks MW, DeFranzo AJ, Molnar JA, David LR. Vacuum-assisted closure: state of clinic art. Plast Reconstr Surg. 2006;117(7S):127S–42S.PubMedCrossRef
9.
go back to reference Shrestha B, Nathan V, Delbridge M, Parker K, Throssell D, McKane W, et al. Vacuum-assisted closure (VAC) therapy in the management of wound infection following renal transplantation. Kathmandu University Medical Journal. 2007;5(1)(17):4–7. Shrestha B, Nathan V, Delbridge M, Parker K, Throssell D, McKane W, et al. Vacuum-assisted closure (VAC) therapy in the management of wound infection following renal transplantation. Kathmandu University Medical Journal. 2007;5(1)(17):4–7.
10.
go back to reference Markić D, Marinović M, Sotošek S, Španjol J, Ivančić A, Maričić A, et al. The role of negative pressure wound therapy in patients with kidney transplantation. Collegium antropologicum. 2014;38(4):1199–201.PubMed Markić D, Marinović M, Sotošek S, Španjol J, Ivančić A, Maričić A, et al. The role of negative pressure wound therapy in patients with kidney transplantation. Collegium antropologicum. 2014;38(4):1199–201.PubMed
11.
go back to reference Barba J, Rosell D, Rincon A, Robles J, Zudaire J, Berian J, et al. New immunosuppressive therapies and surgical complications after renal transplantation. Transplant Proc. 2012;44(5):1275–80.PubMedCrossRef Barba J, Rosell D, Rincon A, Robles J, Zudaire J, Berian J, et al. New immunosuppressive therapies and surgical complications after renal transplantation. Transplant Proc. 2012;44(5):1275–80.PubMedCrossRef
12.
go back to reference Nashan B, Citterio F. Wound healing complications and the use of mammalian target of rapamycin inhibitors in kidney transplantation: a critical review of the literature. Transplantation. 2012;94(6):547–61.PubMedCrossRef Nashan B, Citterio F. Wound healing complications and the use of mammalian target of rapamycin inhibitors in kidney transplantation: a critical review of the literature. Transplantation. 2012;94(6):547–61.PubMedCrossRef
13.
go back to reference Dean PG, Lund WJ, Larson TS, Prieto M, Nyberg SL, Ishitani MB, et al. Wound-healing complications after kidney transplantation: a prospective, randomized comparison of Sirolimus and Tacrolimus1. Transplantation. 2004;77(10):1555–61.PubMedCrossRef Dean PG, Lund WJ, Larson TS, Prieto M, Nyberg SL, Ishitani MB, et al. Wound-healing complications after kidney transplantation: a prospective, randomized comparison of Sirolimus and Tacrolimus1. Transplantation. 2004;77(10):1555–61.PubMedCrossRef
14.
go back to reference Australian Bureau of Statistics. 4364.0.55.001 - National Health Survey: First Results, 2014–15 Canberra, ACT, Australia 2015 [Available from: http://www.abs.gov.au/AUSSTATS/abs@.nsf/Lookup/4364.0.55.001Main+Features12014-15?OpenDocument. Australian Bureau of Statistics. 4364.0.55.001 - National Health Survey: First Results, 2014–15 Canberra, ACT, Australia 2015 [Available from: http://​www.​abs.​gov.​au/​AUSSTATS/​abs@.nsf/Lookup/4364.0.55.001Main+Features12014-15?OpenDocument.
15.
go back to reference Johnson DW, Isbel NM, Brown AM, Kay TD, Franzen K, Hawley CM, et al. The effect of obesity on renal transplant outcomes. Transplantation. 2002;74(5):675–81.PubMedCrossRef Johnson DW, Isbel NM, Brown AM, Kay TD, Franzen K, Hawley CM, et al. The effect of obesity on renal transplant outcomes. Transplantation. 2002;74(5):675–81.PubMedCrossRef
16.
go back to reference Lafranca JA, IJermans JN, Betjes MG, Dor FJ. Body mass index and outcome in renal transplant recipients: a systematic review and meta-analysis. BMC Med. 2015;13(1):111.PubMedPubMedCentralCrossRef Lafranca JA, IJermans JN, Betjes MG, Dor FJ. Body mass index and outcome in renal transplant recipients: a systematic review and meta-analysis. BMC Med. 2015;13(1):111.PubMedPubMedCentralCrossRef
17.
go back to reference Lynch RJ, Ranney DN, Shijie C, Lee DS, Samala N, Englesbe MJ. Obesity, surgical site infection, and outcome following renal transplantation. Ann Surg. 2009;250(6):1014–20.PubMedCrossRef Lynch RJ, Ranney DN, Shijie C, Lee DS, Samala N, Englesbe MJ. Obesity, surgical site infection, and outcome following renal transplantation. Ann Surg. 2009;250(6):1014–20.PubMedCrossRef
18.
go back to reference Singh D, Lawen J, Alkhudair W. Does pretransplant obesity affect the outcome in kidney transplant recipients? Transplant Proc. 2005;37(2):717–20.PubMedCrossRef Singh D, Lawen J, Alkhudair W. Does pretransplant obesity affect the outcome in kidney transplant recipients? Transplant Proc. 2005;37(2):717–20.PubMedCrossRef
19.
go back to reference Harris AD, Fleming B, Bromberg JS, Rock P, Nkonge G, Emerick M, et al. Surgical site infection after renal transplantation. infection control & hospital epidemiology. 2015;36(4):417–23.CrossRef Harris AD, Fleming B, Bromberg JS, Rock P, Nkonge G, Emerick M, et al. Surgical site infection after renal transplantation. infection control & hospital epidemiology. 2015;36(4):417–23.CrossRef
20.
go back to reference Kuo JH, Wong MS, Perez RV, Li C-S, Lin T-C, Troppmann C. Renal transplant wound complications in the modern era of obesity. J Surg Res. 2012;173(2):216–23.PubMedCrossRef Kuo JH, Wong MS, Perez RV, Li C-S, Lin T-C, Troppmann C. Renal transplant wound complications in the modern era of obesity. J Surg Res. 2012;173(2):216–23.PubMedCrossRef
21.
go back to reference Zrim S, Furlong T, Grace BS, Meade A. Body mass index and postoperative complications in kidney transplant recipients. Nephrology. 2012;17(6):582–7.PubMedCrossRef Zrim S, Furlong T, Grace BS, Meade A. Body mass index and postoperative complications in kidney transplant recipients. Nephrology. 2012;17(6):582–7.PubMedCrossRef
22.
go back to reference Orlic L, Mikolasevic I, Jakopcic I, Grskovic A, Jelic Pranjic I, Racki S, et al. Body mass index: short-and long-term impact on kidney transplantation. Int J Clin Pract. 2015;69(11):1357–65.PubMedCrossRef Orlic L, Mikolasevic I, Jakopcic I, Grskovic A, Jelic Pranjic I, Racki S, et al. Body mass index: short-and long-term impact on kidney transplantation. Int J Clin Pract. 2015;69(11):1357–65.PubMedCrossRef
23.
go back to reference Doyle S, Lysaght J, Reynolds J. Obesity and post-operative complications in patients undergoing non-bariatric surgery. Obes Rev. 2010;11(12):875–86.PubMedCrossRef Doyle S, Lysaght J, Reynolds J. Obesity and post-operative complications in patients undergoing non-bariatric surgery. Obes Rev. 2010;11(12):875–86.PubMedCrossRef
24.
go back to reference Taha M, Davis NF, Power R, Mohan P, Forde J, Smyth G, et al. Increased mid-abdominal circumference is a predictor for surgical wound complications in kidney transplant recipients: a prospective cohort study. Clin Transpl. 2017;31(5). Taha M, Davis NF, Power R, Mohan P, Forde J, Smyth G, et al. Increased mid-abdominal circumference is a predictor for surgical wound complications in kidney transplant recipients: a prospective cohort study. Clin Transpl. 2017;31(5).
26.
27.
go back to reference Hjortrup A, Sørensen C, Dyremose E, Hjortsø NC, Kehlet H. Influence of diabetes mellitus on operative risk. Br J Surg. 1985;72(10):783–5.PubMedCrossRef Hjortrup A, Sørensen C, Dyremose E, Hjortsø NC, Kehlet H. Influence of diabetes mellitus on operative risk. Br J Surg. 1985;72(10):783–5.PubMedCrossRef
28.
go back to reference Pavlidis TE, Galatianos IN, Papaziogas BT, Lazaridis CN, Atmatzidis KS, Makris JG, et al. Complete dehiscence of the abdominal wound and incriminating factors. The European journal of surgery. 2001;167(5):351–4.PubMedCrossRef Pavlidis TE, Galatianos IN, Papaziogas BT, Lazaridis CN, Atmatzidis KS, Makris JG, et al. Complete dehiscence of the abdominal wound and incriminating factors. The European journal of surgery. 2001;167(5):351–4.PubMedCrossRef
29.
go back to reference Treckmann JW, Goldenberg A, Malamutmann E, Witzke O, Fouzas I, Paul A, et al. Kidney transplantation in patients with diabetes mellitus: surgical complications. Hepato-Gastroenterology. 2011;58:738–9.PubMed Treckmann JW, Goldenberg A, Malamutmann E, Witzke O, Fouzas I, Paul A, et al. Kidney transplantation in patients with diabetes mellitus: surgical complications. Hepato-Gastroenterology. 2011;58:738–9.PubMed
30.
go back to reference Armstrong DG, Lavery LA, Consortium DFS. Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial. Lancet. 2005;366(9498):1704–10.PubMedCrossRef Armstrong DG, Lavery LA, Consortium DFS. Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial. Lancet. 2005;366(9498):1704–10.PubMedCrossRef
31.
go back to reference Huang C, Leavitt T, Bayer LR, Orgill DP. Effect of negative pressure wound therapy on wound healing. Curr Probl Surg. 2014;51(7):301–31.PubMedCrossRef Huang C, Leavitt T, Bayer LR, Orgill DP. Effect of negative pressure wound therapy on wound healing. Curr Probl Surg. 2014;51(7):301–31.PubMedCrossRef
32.
go back to reference Santangelo M, De Rosa P, Spiezia S, Spinosa G, Grassia S, Zuccaro M, et al. Healing of surgical incision in kidney transplantation: a single transplant center’s experience. Transplant Proc. 2006;38(4):1044–6.PubMedCrossRef Santangelo M, De Rosa P, Spiezia S, Spinosa G, Grassia S, Zuccaro M, et al. Healing of surgical incision in kidney transplantation: a single transplant center’s experience. Transplant Proc. 2006;38(4):1044–6.PubMedCrossRef
33.
go back to reference Tan A, Gollop N, Klimach S, Maruthappu M, Smith S. Should infected laparotomy wounds be treated with negative pressure wound therapy? Int J Surg. 2014;12(1):26–9.PubMedCrossRef Tan A, Gollop N, Klimach S, Maruthappu M, Smith S. Should infected laparotomy wounds be treated with negative pressure wound therapy? Int J Surg. 2014;12(1):26–9.PubMedCrossRef
34.
go back to reference Heap S, Mehra S, Tavakoli A, Augustine T, Riad H, Pararajasingam R. Negative pressure wound therapy used to heal complex urinary fistula wounds following renal transplantation into an ileal conduit. Am J Transplant. 2010;10(10):2370–3.PubMedCrossRef Heap S, Mehra S, Tavakoli A, Augustine T, Riad H, Pararajasingam R. Negative pressure wound therapy used to heal complex urinary fistula wounds following renal transplantation into an ileal conduit. Am J Transplant. 2010;10(10):2370–3.PubMedCrossRef
35.
go back to reference Franchin M, Tozzi M, Soldini G. Piffaretti G. a case of continuous negative pressure wound therapy for abdominal infected lymphocele after kidney transplantation. Case reports in transplantation. 2014:742161. Franchin M, Tozzi M, Soldini G. Piffaretti G. a case of continuous negative pressure wound therapy for abdominal infected lymphocele after kidney transplantation. Case reports in transplantation. 2014:742161.
36.
go back to reference Ortiz J, Siddeswarappa M, Stewart S, Khanmoradi K, Campos S, Zaki R. Negative pressure therapy may delay resolution of urinary leaks. Am J Transplant. 2011;11(2):412.PubMedCrossRef Ortiz J, Siddeswarappa M, Stewart S, Khanmoradi K, Campos S, Zaki R. Negative pressure therapy may delay resolution of urinary leaks. Am J Transplant. 2011;11(2):412.PubMedCrossRef
37.
go back to reference Bozkurt B, Tokac M, Dumlu E, Yalcin A, Kilic M. Our first experience with negative pressure incision management system implemented on the clean surgical incision in the renal transplantation recipient: a case report. Transplant Proc. 2015;47(5):1515–7.PubMedCrossRef Bozkurt B, Tokac M, Dumlu E, Yalcin A, Kilic M. Our first experience with negative pressure incision management system implemented on the clean surgical incision in the renal transplantation recipient: a case report. Transplant Proc. 2015;47(5):1515–7.PubMedCrossRef
38.
go back to reference Zhen ZJ, Lai EC, Lee QH, Chen HW, Lau WY, Wang FJ. Conventional wound management versus a closed suction irrigation method for infected laparotomy wound–a comparative study. Int J Surg. 2011;9(5):378–81.PubMedCrossRef Zhen ZJ, Lai EC, Lee QH, Chen HW, Lau WY, Wang FJ. Conventional wound management versus a closed suction irrigation method for infected laparotomy wound–a comparative study. Int J Surg. 2011;9(5):378–81.PubMedCrossRef
39.
go back to reference Harris AD, Fleming B, Bromberg JS, Rock P, Nkonge G, Emerick M, et al. Surgical site infection after renal transplantation. Infect Control Hosp Epidemiol. 2015;36(4):417–23.PubMedPubMedCentralCrossRef Harris AD, Fleming B, Bromberg JS, Rock P, Nkonge G, Emerick M, et al. Surgical site infection after renal transplantation. Infect Control Hosp Epidemiol. 2015;36(4):417–23.PubMedPubMedCentralCrossRef
Metadata
Title
Abdominal wall complications following renal transplantation in adult recipients – factors associated with interventional management in one unit
Authors
Ngee-Soon Lau
Nima Ahmadi
Deborah Verran
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Surgery / Issue 1/2019
Electronic ISSN: 1471-2482
DOI
https://doi.org/10.1186/s12893-019-0468-x

Other articles of this Issue 1/2019

BMC Surgery 1/2019 Go to the issue