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Open Access 01-12-2017 | Research article

Therapeutic effects of flurbiprofen axetil on mesenteric traction syndrome: randomized clinical trial

Authors: Hidemasa Takahashi, Dai Shida, Kyoko Tagawa, Ryo Iwamoto, Makoto Arita, Hiroyuki Arai, Takeo Suzuki

Published in: BMC Surgery | Issue 1/2017

Abstract

Background

This study aimed to reveal the appropriate timing for the intravenous administration of flurbiprofen axetil for preventing mesenteric traction syndrome (MTS), caused by prostacyclin release.

Methods

In this prospective, randomized, clinical study, forty-five patients who were undergoing elective surgery for colorectal cancer via laparotomy were enrolled. Patients were randomly divided into 3 groups: a preoperative group (n = 16) receiving flurbiprofen axetil directly before surgery; a post-MTS group (n = 14) receiving following MTS onset; and a control group (n = 15) who were not administered flurbiprofen axetil. 6-keto-PGF1α, a stable metabolite of prostacyclin, levels were measured and mean blood pressures were recorded.

Results

In the preoperative group, 6-keto-PGF1α levels did not increase, blood pressure levels did not decrease, and no facial flushing was observed. In both the post-MTS and control groups, 6-keto-PGF1α levels increased markedly after mesenteric traction and blood pressure decreased significantly. The post-MTS group exhibited a faster decreasing trend in 6-keto-PGF1α levels and quick restore of the mean blood pressure, and the use of vasopressors and phenylephrine were lower than that in the control group.

Conclusions

Even therapeutic administration of flurbiprofen axetil after the onset of MTS has also effects on MTS by suppressing prostacyclin production.

Trial registration

Clinical trial number: UMIN000009111. (Registered 14 October 2012)

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Title: Therapeutic effects of flurbiprofen axetil on mesenteric traction syndrome: randomized clinical trial
Authors: Hidemasa Takahashi
Dai Shida
Kyoko Tagawa
Ryo Iwamoto
Makoto Arita
Hiroyuki Arai
Takeo Suzuki
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: BMC Surgery / Issue 1/2017
Electronic ISSN: 1471-2482
DOI: https://doi.org/10.1186/s12893-017-0286-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Therapeutic effects of flurbiprofen axetil on mesenteric traction syndrome: randomized clinical trial

Abstract

Background

Methods

Results

Conclusions

Trial registration

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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