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BMC Surgery
Published in: BMC Surgery 1/2015

Open Access 01-12-2015 | Case report

A case report of primary neuroendocrine carcinoma of the perihilar bile duct

Authors: Yasuhiro Kihara, Hiroshi Yokomizo, Takahiro Urata, Michiko Nagamine, Toshihiko Hirata

Published in: BMC Surgery | Issue 1/2015

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Abstract

Background

Although neuroendocrine tumors are most commonly found in the digestive system, neuroendocrine tumors originating from the bile duct are rare, and neuroendocrine carcinomas derived from the perihilar bile duct are extremely rare. This report presents the clinical course and clinicopathological features of neuroendocrine carcinomas arising from the extrahepatic bile duct.

Case presentation

A 70-year-old Japanese woman was preoperatively diagnosed with perihilar cholangiocarcinoma, and a radical resection with an extended left hepatic lobectomy and a choledochojejunostomy was performed. From the histopathological findings, we diagnosed the tumor as a neuroendocrine carcinoma of the bile duct (small cell type) with lymph node metastasis. The patient was treated with the same adjuvant chemotherapy as that used for small cell carcinoma of the lung. At 10 months after surgery, there was no recurrence of the disease.

Conclusion

Neuroendocrine carcinoma of the extrahepatic biliary tracts is a very rare and highly malignant disease with a poor prognosis. A multidisciplinary approach could improve the prognosis for this neoplasm.
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Metadata
Title
A case report of primary neuroendocrine carcinoma of the perihilar bile duct
Authors
Yasuhiro Kihara
Hiroshi Yokomizo
Takahiro Urata
Michiko Nagamine
Toshihiko Hirata
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Surgery / Issue 1/2015
Electronic ISSN: 1471-2482
DOI
https://doi.org/10.1186/s12893-015-0116-z

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