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BMC Surgery
Published in: BMC Surgery 1/2015

Open Access 01-12-2015 | Research article

Outcomes of resections for pancreatic adenocarcinoma with suspected venous involvement: a single center experience

Authors: Christoph W. Michalski, Bo Kong, Carsten Jäger, Silke Kloe, Barbara Beier, Rickmer Braren, Irene Esposito, Mert Erkan, Helmut Friess, Jorg Kleeff

Published in: BMC Surgery | Issue 1/2015

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Abstract

Background

Pancreatic ductal adenocarcinoma (PDAC) patients frequently present with borderline resectable disease, which can be due to invasion of the portal/superior mesenteric vein (PV/SMV). Here, we analyzed this group of patients, with emphasis on short and long-term outcomes.

Methods

156 patients who underwent a resection for PDAC were included in the analysis and sub-stratified into a cohort of patients with PV/SMV resection (n = 54) versus those with standard surgeries (n = 102).

Results

While venous resections could be performed safely, there was a trend towards shorter median survival in the PV/SMV resection group (22.7 vs. 15.8 months, p = 0.157). These tumors were significantly larger (3.5 vs 4.3 cm; p = 0.026) and margin-positivity was more frequent (30.4 % vs 44.4 %, p = 0.046).

Conclusion

Venous resection was associated with a higher rate of margin positivity and a trend towards shorter survival. However, compared to non-surgical treatment, resection offers the best chance for long term survival.
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Metadata
Title
Outcomes of resections for pancreatic adenocarcinoma with suspected venous involvement: a single center experience
Authors
Christoph W. Michalski
Bo Kong
Carsten Jäger
Silke Kloe
Barbara Beier
Rickmer Braren
Irene Esposito
Mert Erkan
Helmut Friess
Jorg Kleeff
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Surgery / Issue 1/2015
Electronic ISSN: 1471-2482
DOI
https://doi.org/10.1186/s12893-015-0086-1

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