Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2020

Open Access 01-12-2020 | Research article

Comparative study of imaging and histology of sacroiliac joint in normal rats based on IVIM-DWI and DCE-MRI

Authors: Jian Qin, Qianqian Yao, Xubo Ge, Jianzhong Zhu, Zhaoliang Yin, Xiaoqian Li, Changqin Li

Published in: BMC Musculoskeletal Disorders | Issue 1/2020

Login to get access

Abstract

Background

Currently, few studies have described the relationship between functional MRI findings and histology of normal sacroiliac joint (SIJ). Besides, due to the difficulties in access to SIJ, authentic animal models are important in providing opportunities for quantitative parameter extraction on imaging.

Aims

This study aimed at exploring the parameters of Intravoxel Incoherent Motion Diffusion-Weighted Imaging (IVIM-DWI) and Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) and comparing them with the histology of the SIJ in normal rats with different ages.

Methods

A total of thirty 7-week-old male Wistar rats were included in the study. The parameters of IVIM-DWI and DCE-MRI in the bone marrow and the joint space of SIJ were measured at 8, 13, 18, 23, 28, and 33 weeks. The histological analysis of the SIJ was examined using light microscopy. One-way ANOVA was used for statistical analysis.

Results

The D values in the sacral and iliac bone marrow of normal rats decreased with an increase in age. One-way ANOVA analysis indicated a significant difference in D values in different age groups (P<0.005). The normal values of D*, f, Fenh (%), Senh (%/s) in the sacral bone marrow, the iliac bone marrow, and the joint space in SIJ of normal rats were obtained. The results showed that in the six groups of rats of different ages, the histology of the SIJ surface was smooth and clear, the cartilage cells were intact, and no thickening or pannus formation was observed.

Conclusions

This study obtained the IVIM-DWI and DCE-MRI parameters of the sacral and iliac bone marrow and the synovial area of the joint space in normal rats. The parameters in normal rats can be used in future research to compare to similar parameters in animal models or patients with SIJ diseases. This study serves as a guide for future research in SIJ diseases.
Literature
1.
Stallmeyer MJ, Ortiz AO. Facet blocks and sacroiliac joint injections. Tech Vasc Interv Radiol. 2002;5:201–6.CrossRef
2.
Van Hauwermeiren L, Verstraete M, Stouthandel MEJ, et al. Joint coordinate system for biomechanical analysis of the sacroiliac joint. J Orthop Res. 2019;37:1101–9.CrossRef
3.
Rudwaleit M, Metter A, Listing J, et al. Inflammatory back pain in ankylosing spondylitis: a reassessment of the clinical history for application as classification and diagnostic criteria. Arthritis Rheum. 2006;54:569–78.CrossRef
4.
Cohen SP, Chen Y, Neufeld NJ. Sacroiliac joint pain: a comprehensive review of epidemiology, diagnosis and treatment. Expert Rev Neurother. 2013;13:99–116.CrossRef
5.
Vleeming A, Schuenke MD, Masi AT, et al. The sacroiliac joint: an overview of its anatomy, function and potential clinical implications. J Anat. 2012;221:537–67.CrossRef
6.
Barker PJ, Hapuarachchi KS, Ross JA, et al. Anatomy and biomechanics of gluteus maximus and the thoracolumbar fascia at the sacroiliac joint. Clin Anat. 2014;27:234–40.CrossRef
7.
Sichting F, Rossol J, Soisson O, et al. Pelvic belt effects on sacroiliac joint ligaments: a computational approach to understand thera peutic effects of pelvic belts. Pain Physician. 2014;17:43–51.PubMed
8.
Maksymowych WP, Wichuk S, Dougados M, et al. MRI evidence of structural changes in the sacroiliac joints of patients with non-radiographic axial spondyloarthritis even in the absence of MRI inflammation. Arthritis Res Therapy. 2017;19:126.CrossRef
9.
Puhakka KB, Melsen F, Jurik AG, et al. MR imaging of the normal sacroiliac joint with correlation to histology. Skelet Radiol. 2004;33:15–28.CrossRef
10.
Le Bihan D, Breton E, Lallemand D, et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology. 1986;161:401–7.CrossRef
11.
Maksymowych WP, Lambert RG, Østergaard M, et al. MRI lesions in the sacroiliac joints of patients with spondyloarthritis: an update of definitions and validation by the ASAS MRI working group. Ann Rheumatic Dis. 2019;78(11):1550–8.CrossRef
12.
Tan S. Computed tomography in axial spondyloarthritis. Curr Opinion Rheumatol. 2018;30:334–9.CrossRef
13.
El Rafei M, Badr S, Lefebvre G, et al. Sacroiliac joints: anatomical variations on MR images. Eur Radiol. 2018;28:5328–37.CrossRef
14.
Jans L, Egund N, Eshed I, Sudoł-Szopińska I, et al. Sacroiliitis in axial Spondyloarthritis: assessing morphology and activity. Seminars in musculoskeletal radiology. 2018;22:180–8.CrossRef
15.
Qin J, Li J, Yang H, et al. Values of intravoxel incoherent motion diffusion weighted imaging and dynamic contrast-enhanced MRI in evaluating the activity of sacroiliitis in ankylosing spondylitis of rat model. Magnetic Resonance Imaging. 2020;68:30–5.CrossRef
16.
Fujima N, Sakashita T, Homma A, et al. Advanced diffusion models in head and neck squamous cell carcinoma patients: goodness of fit, relationships among diffusion parameters and comparison with dynamic contrast-enhanced perfusion. Magn Reson Imaging. 2017;36:16–23.CrossRef
17.
Kim SH, Choi MS, Kim MJ, et al. Role of semi-quantitative dynamic contrast-enhanced MR imaging in characterization and grading of prostate cancer. Eur J Radiol. 2017;94:154–9.CrossRef
18.
Shinmoto H, Tamura C, Soga S, et al. An intravoxel incoherent motion diffusion-weighted imaging study of prostate cancer. Am J Roentgenol. 2012;199:W496–500.CrossRef
19.
Murata Y, Kubota K, Hamada N, et al. Diffusion-weighted magnetic resonance imaging for assessment after neoadjuvant chemotherapy in breast cancer, based on morphological concepts. Oncol Letters. 2010;1:293–8.CrossRef
20.
Sandrasegaran K, Territo P, Elkady RM, et al. Does intravoxel incoherent motion reliably stage hepatic fibrosis, steatosis, and inflammation? Abdominal Radiol. 2018;43:600–6.CrossRef
21.
Winalski CS. The evolution of articular cartilage imaging and its impact on clinical practice. Skeletal Radiol. 2011;40:1197–222.CrossRef
Metadata
Title
Comparative study of imaging and histology of sacroiliac joint in normal rats based on IVIM-DWI and DCE-MRI
Authors
Jian Qin
Qianqian Yao
Xubo Ge
Jianzhong Zhu
Zhaoliang Yin
Xiaoqian Li
Changqin Li
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2020
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-020-03481-1

Other articles of this Issue 1/2020

BMC Musculoskeletal Disorders 1/2020 Go to the issue

Research article

Radiographic and clinical outcome of lateral lumbar interbody fusion for extreme lumbar spinal stenosis of Schizas grade D: a retrospective study

Research article

Tourniquet use in routine primary total knee arthroplasty is associated with a higher transfusion rate and longer postoperative length of stay: a real-world study

Research article

Implementing early mobilisation after knee or hip arthroplasty to reduce length of stay: a quality improvement study with embedded qualitative component

Research article

Bone mineral density reference values in Singaporean adults and comparisons for osteoporosis establishment – The Yishun Study

Research article

The severity of developmental dysplasia of the hip does not correlate with the abnormality in pelvic incidence

Research article

Degenerative central lumbar spinal stenosis: is endoscopic decompression through bilateral transforaminal approach sufficient?