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BMC Musculoskeletal Disorders

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01-12-2020 | Magnetic Resonance Imaging | Research article

The correlation between follow-up MRI findings and laboratory results in pyogenic spondylodiscitis

Authors: Kyung-Sik Ahn, Chang Ho Kang, Suk-Joo Hong, Baek Hyun Kim, Euddeum Shim

Published in: BMC Musculoskeletal Disorders | Issue 1/2020

Abstract

Background

Although MRI is the gold-standard imaging method in the diagnosis of spondylodiscitis, role of follow-up imaging is debated and there can be discrepancies with regard to the significance of bony or soft tissue responses to treatment. Purpose of our study is to test whether the MRI changes on follow-up imaging correlate with laboratory findings of treatment response.

Methods

A total of 48 patients with pyogenic spondylodiscitis who underwent baseline and follow-up MRI were retrospectively reviewed. The extent of bone marrow edema, paravertebral soft tissue inflammation, and disc height were compared on baseline and follow-up MRIs with the C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels obtained from the medical records at baseline and on follow-up. Relationships between the MRI and laboratory changes were analyzed using the Spearmann correlation test.

Results

The mean MRI follow-up period was 42.25 days. Based on the CRP (resolved: n = 19, resolving: n = 19, and aggravated: n = 10), there was significant correlation between the laboratory results and the changes in the bone and soft tissues (p < 0.01, both). The correlation was best with soft tissue changes (rho: 0.48) followed by bony changes (rho: 0.41). Based on the ESR (resolved: n = 8, resolving: n = 22, and worsened: n = 18), the correlation was stronger with bone changes (rho: 0.45, p < 0.01) than it was with soft tissue changes (rho: 0.39, p = 0.01).

Conclusion

Follow-up MRI findings of pyogenic spondylodiscitis show variable tissue responses. CRP was best correlated with soft tissue changes, while ESR showed the best association with bony changes.

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Title: The correlation between follow-up MRI findings and laboratory results in pyogenic spondylodiscitis
Authors: Kyung-Sik Ahn
Chang Ho Kang
Suk-Joo Hong
Baek Hyun Kim
Euddeum Shim
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Spondylodiscitis
Published in: BMC Musculoskeletal Disorders / Issue 1/2020
Electronic ISSN: 1471-2474
DOI: https://doi.org/10.1186/s12891-020-03446-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The correlation between follow-up MRI findings and laboratory results in pyogenic spondylodiscitis

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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