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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2020

01-12-2020 | Osteoarthrosis | Study protocol

Investigating musculoskeletal health and wellbeing; a cohort study protocol

Authors: Bonnie Millar, Daniel F. McWilliams, Abhishek Abhishek, Kehinde Akin-Akinyosoye, Dorothee P. Auer, Victoria Chapman, Michael Doherty, Eamonn Ferguson, John R. F. Gladman, Paul Greenhaff, Joanne Stocks, Ana M. Valdes, David A. Walsh

Published in: BMC Musculoskeletal Disorders | Issue 1/2020

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Abstract

Background

In an ageing population, pain, frailty and disability frequently coexist across a wide range of musculoskeletal diagnoses, but their associations remain incompletely understood. The Investigating Musculoskeletal Health and Wellbeing (IMH&W) study aims to measure and characterise the development and progression of pain, frailty and disability, and to identify discrete subgroups and their associations. The survey will form a longitudinal context for nested research, permitting targeted recruitment of participants for qualitative, observational and interventional studies; helping to understand recruitment bias in clinical studies; and providing a source cohort for cohort randomised controlled trials.

Methods

IMH&W will comprise a prospective cohort of 10,000 adults recruited through primary and secondary care, and through non-clinical settings. Data collection will be at baseline, and then through annual follow-ups for 4 years. Questionnaires will address demographic characteristics, pain severity (0–10 Numerical Rating Scale), pain distribution (reported on a body Manikin), pain quality (McGill Pain Questionnaire), central aspects of pain (CAP-Knee), frailty and disability (based on Fried criteria and the FRAIL questionnaire), and fracture risk. Baseline characteristics, progression and associations of frailty, pain and disability will be determined. Discrete subgroups and trajectories will be sought by latent class analysis. Recruitment bias will be explored by comparing participants in nested studies with the eligible IMH&W population.

Discussion

IMH&W will elucidate associations and progression of pain, frailty and disability. It will enable identification of people at risk of poor musculoskeletal health and wellbeing outcomes who might be suitable for specific interventions, and facilitate generalisation and comparison of research outcomes between target populations. The study will benefit from a large sample size and will recruit from diverse regions across the UK. Purposive recruitment will enrich the cohort with people with MSK problems with high representation of elderly and unwell people.

Trial registration

Clinicaltrials.gov NCT03696134. Date of Registration: 04 October 2018.
Appendix
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Metadata
Title
Investigating musculoskeletal health and wellbeing; a cohort study protocol
Authors
Bonnie Millar
Daniel F. McWilliams
Abhishek Abhishek
Kehinde Akin-Akinyosoye
Dorothee P. Auer
Victoria Chapman
Michael Doherty
Eamonn Ferguson
John R. F. Gladman
Paul Greenhaff
Joanne Stocks
Ana M. Valdes
David A. Walsh
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2020
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-020-03195-4

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