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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2018

Open Access 01-12-2018 | Case report

Calcification of the intervertebral disc and ossification of posterior longitudinal ligament in children

Authors: Jun-Jie Du, Yu-Fei Chen, Ye Peng, Xiao-jie Li, Wei Ma

Published in: BMC Musculoskeletal Disorders | Issue 1/2018

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Abstract

Background

IDC in children, first reported by Baron in 1924, is very rare. OPLL of the cervical spine mainly affect people ages 50–70 years. The coexistence of IDC and OPLL in children is very rare, only six cases with 3 to 24 months’ follow-up were reported to date.

Case presentation

A 6-year-old boy presented with complains of neck pain at July 2007. The boy was treated by conservative treatment and observed up for 9 years. Neck pain greatly improved after a one-month conservative treatment and never recur. Laboratory tests revealed elevated ESR and CRP at admission and found nothing abnormal at 19-month and 9-year follow-up. Computed tomography and magnetic resonance imaging revealed IDC at C2/3, C3/4 and OPLL at C3/4 at admission and found minor calcification at C2/3 remained but calcification at C3/4 and OPLL at C3/4 completely disappeared at 19-month and 9-year follow-up. Nineteen months after initial diagnosis, restoration of T2-weighted signal intensity of C2/3 and C3/4 discs was observed through MRI. Loss of T2-weighted signal intensity of C2/3 disc and decrease of T2-weighted signal intensity of C3/4 disc was observed at 9-year follow-up.

Conclusions

IDC with OPLL in children is very rare. Conservative treatments are recommended with affirmative short-term and long-term clinical effects. More intensive observation with long-term follow-ups may be needed to warrant the clinical effects.
Literature
1.
Lam SK, Niedzwecki CM, Daniels B, Mayer RR, Vakharia MM, Jea A. Acute spinal cord injury associated with multilevel pediatric idiopathic intervertebral disc calcification: case report. J Neurosurg Pediatr. 2016;17(2):182–6.CrossRefPubMed
2.
Fu Z, Shi J, Jia L Jr, Yuan W Jr, Guan Z. Intervertebral thoracic disc calcification associated with ossification of posterior longitudinal ligament in an eleven-year-old child. Spine (Phila Pa 1976). 2011;36(12):E808–10.CrossRef
3.
Du JJ, Meng H, Cao YJ, Li FQ, Luo ZJ. Calcification of the intervertebral disc and posterior longitudinal ligament in children. J Spinal Disord Tech. 2012;25(1):59–63.CrossRefPubMed
4.
Wang G, Kang Y, Chen F, Wang B. Cervical intervertebral disc calcification combined with ossification of posterior longitudinal ligament in an-11-year old girl: case report and review of literature. Childs Nerv Syst. 2016;32(2):381–6.CrossRefPubMed
5.
Mizukawa K, Kobayashi T, Yamada N, Hirota T. Intervertebral disc calcification with ossification of the posterior longitudinal ligament. Pediatr Int. 2017;59(5):622–4.CrossRefPubMed
6.
O’Dell MC, Flores M, Murray JV Jr. Pediatric idiopathic intervertebral disc calcification. Pediatr Neurol. 2016;61:115–6.CrossRefPubMed
7.
Beluffi G, Fiori P, Sileo C. Intervertebral disc calcifications in children. Radiol Med. 2009;114(2):331–41.CrossRefPubMed
8.
Blomquist HK, Lindqvist M, Mattsson S. Calcification of intervertebral discs in childhood. Pediatr Radiol. 1979;8(1):23–6.CrossRefPubMed
9.
Dai LY, Ye H, Qian QR. The natural history of cervical disc calcification in children. J Bone Joint Surg Am. 2004;86-A(7):1467–72.CrossRefPubMed
10.
Bajard X, Renault F, Benharrats T, Mary P, Madi F, Vialle R. Intervertebral disc calcification with neurological symptoms in children: report of conservative treatment in two cases. Childs Nerv Syst. 2010;26(7):973–8.CrossRefPubMed
11.
Yang HS, Chen DY, Yuan W, Yang LL, Tsai N, Lin QS. Paresis associated with aconuresis caused by intervertebral disc calcification at c7-t1: a case report and review of the literature. Spine (Phila Pa 1976). 2010;35(10):E434–9.CrossRef
12.
El Demellawy D, Robison JG, Pollack IF, Green MD, Alper CM, Reyes-Mugica M. Idiopathic intervertebral disc calcification in childhood: an atypical case of an uncommon entity for pediatric pathologists. Pediatr Dev Pathol. 2013;16(6):432–7.CrossRefPubMed
13.
Lernout C, Haas H, Rubio A, Griffet J. Pediatric intervertebral disk calcification in childhood: three case reports and review of literature. Childs Nerv Syst. 2009;25(8):1019–23.CrossRefPubMed
14.
Ho C, Chang S, Fulkerson D, Smith J. Children presenting with calcified disc herniation: a self-limiting process. J Radiol Case Rep. 2012;6(10):11–9.PubMedPubMedCentral
15.
Tsutsumi S, Yasumoto Y, Ito M. Idiopathic intervertebral disk calcification in childhood: a case report and review of literature. Childs Nerv Syst. 2011;27(7):1045–51.CrossRefPubMed
16.
Liu W, Tang C, Liu L, Zhu QS, Huang LF. Cervical intervertebral disc calcification with extreme lateral herniation in a child: T2-weighted signal intensity of the involved disc can be restored to normal. Childs Nerv Syst. 2016;32(4):749–52.CrossRefPubMed
17.
Swischuk LE, Jubang M, Jadhav SP. Calcific discitis in children: vertebral body involvement (possible insight into etiology). Emerg Radiol. 2008;15(6):427–30.CrossRefPubMed
18.
Rutges J, Creemers LB, Dhert W, Milz S, Sakai D, Mochida J, Alini M, Grad S. Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration. Osteoarthr Cartil. 2010;18(3):416–23.CrossRefPubMed
19.
Sonnabend DH, Taylor TK, Chapman GK. Intervertebral disc calcification syndromes in children. J Bone Joint Surg Br. 1982;64(1):25–31.CrossRefPubMed
20.
Fargen KM, Cox JB, Hoh DJ. Does ossification of the posterior longitudinal ligament progress after laminoplasty? Radiographic and clinical evidence of ossification of the posterior longitudinal ligament lesion growth and the risk factors for late neurologic deterioration. J Neurosurg Spine. 2012;17(6):512–24.CrossRefPubMed
21.
Matsunaga S, Sakou T. Ossification of the posterior longitudinal ligament of the cervical spine: etiology and natural history. Spine (Phila Pa 1976). 2012;37(5):E309–14.CrossRef
22.
Abiola R, Rubery P, Mesfin A. Ossification of the posterior longitudinal ligament: etiology, diagnosis, and outcomes of nonoperative and operative management. Global Spine J. 2016;6(2):195–204.CrossRefPubMed
23.
Stapleton CJ, Pham MH, Attenello FJ, Hsieh PC. Ossification of the posterior longitudinal ligament: genetics and pathophysiology. Neurosurg Focus. 2011;30(3):E6.CrossRefPubMed
24.
Iwasaki M, Okuda S, Miyauchi A, Sakaura H, Mukai Y, Yonenobu K, Yoshikawa H. Surgical strategy for cervical myelopathy due to ossification of the posterior longitudinal ligament: part 2: advantages of anterior decompression and fusion over laminoplasty. Spine (Phila Pa 1976). 2007;32(6):654–60.CrossRef
25.
Sasaki E, Ono A, Yokoyama T, Wada K, Tanaka T, Kumagai G, Iwasaki H, Takahashi I, Umeda T, Nakaji S, et al. Prevalence and symptom of ossification of posterior longitudinal ligaments in the Japanese general population. J Orthop Sci. 2014;19(3):405–11.CrossRefPubMed
26.
Sohn S, Chung CK, Yun TJ, Sohn CH. Epidemiological survey of ossification of the posterior longitudinal ligament in an adult Korean population: three-dimensional computed tomographic observation of 3,240 cases. Calcif Tissue Int. 2014;94(6):613–20.CrossRefPubMed
27.
Kusabiraki S, Tsubata S. Two karate kids with pediatric idiopathic intervertebral disc calcification. Spine J. 2014;14(12):3048.CrossRefPubMed
28.
Kim HR, Ha DH, Lee SM, Kim SH, Wenokor C. Acute symptomatic intervertebral disk calcification in a child with retropharyngeal edema: computed tomography and magnetic resonance findings. J Clin Rheumatol. 2011;17(7):365–7.CrossRefPubMed
29.
Chu J, Wang T, Pei S, Yin Z. Surgical treatment for idiopathic intervertebral disc calcification in a child: case report and review of the literature. Childs Nerv Syst. 2015;31(1):123–7.CrossRefPubMed
30.
Kawaguchi Y, Nakano M, Yasuda T, Seki S, Suzuki K, Yahara Y, Makino H, Kitajima I, Kimura T. Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): inflammation in OPLL. PLoS One. 2017;12(5):e0174881.CrossRefPubMedPubMedCentral
31.
32.
Okamoto K, Kobashi G, Washio M, Sasaki S, Yokoyama T, Miyake Y, Sakamoto N, Ohta K, Inaba Y, Tanaka H, et al. Dietary habits and risk of ossification of the posterior longitudinal ligaments of the spine (OPLL); findings from a case-control study in Japan. J Bone Miner Metab. 2004;22(6):612–7.CrossRefPubMed
33.
Akune T, Ogata N, Seichi A, Ohnishi I, Nakamura K, Kawaguchi H. Insulin secretory response is positively associated with the extent of ossification of the posterior longitudinal ligament of the spine. J Bone Joint Surg Am. 2001;83-A(10):1537–44.CrossRefPubMed
34.
Ono K, Yonenobu K, Miyamoto S, Okada K. Pathology of ossification of the posterior longitudinal ligament and ligamentum flavum. Clin Orthop Relat Res. 1999;359:18–26.CrossRef
35.
Mahapatra SK, Sud A, Mehtani A. Pediatric cervical disc calcification simulating tubercular spondylitis - a case report. J Clin Orthop Trauma. 2013;4(1):46–8.CrossRefPubMedPubMedCentral
36.
Sasagawa T, Hashimoto F, Nakamura T, Maruhasi Y, Matsumoto N, Segawa T, Yamamoto D, Goshima K, Murakami H, Tsuchiya H. A pediatric case of single-level idiopathic cervical intervertebral disk calcification with symptom relapse 1 year after initial onset. J Pediatr Orthop. 2014;34(3):282–6.CrossRefPubMed
37.
Hoffman AI, Lambiase RE, Levine SM. Intervertebral cervical disk calcification requiring operative management in a child. AJR Am J Roentgenol. 1998;171(3):898–9.CrossRefPubMed
38.
Pham MH, Attenello FJ, Lucas J, He S, Stapleton CJ, Hsieh PC. Conservative management of ossification of the posterior longitudinal ligament. A review. Neurosurg Focus. 2011;30(3):E2.CrossRefPubMed
39.
Wong CC, Pereira B, Pho RW. Cervical disc calcification in children. A long-term review. Spine (Phila Pa 1976). 1992;17(2):139–44.CrossRef
40.
Sieron D, Gruszczynska K, Machnikowska-Sokolowska M, Olczak Z, Knap D, Baron J. Intervertebral disc calcification in children: case description and review of relevant literature. Pol J Radiol. 2013;78(1):78–80.CrossRefPubMedPubMedCentral
41.
Bagatur AE, Zorer G, Centel T. Natural history of paediatric intervertebral disc calcification. Arch Orthop Trauma Surg. 2001;121(10):601–3.CrossRefPubMed
42.
Spapens N, Wouters C, Moens P. Thoracolumbar intervertebral disc calcifications in an 8-year-old boy: case report and review of the literature. Eur J Pediatr. 2010;169(5):577–80.CrossRefPubMed
43.
44.
Hadjipavlou AG, Tzermiadianos MN, Bogduk N, Zindrick MR. The pathophysiology of disc degeneration: a critical review. J Bone Joint Surg Br. 2008;90(10):1261–70.CrossRefPubMed
45.
Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976). 2001;26(17):1873–8.CrossRef
46.
Yilmaz A, Senturk S, Sasani M, Oktenoglu T, Yaman O, Yildirim H, Suzer T, Ozer AF. Disc rehydration after dynamic stabilization: a report of 59 cases. Asian Spine J. 2017;11(3):348–55.CrossRefPubMedPubMedCentral
47.
Fay LY, Wu JC, Tsai TY, Tu TH, Wu CL, Huang WC, Cheng H. Intervertebral disc rehydration after lumbar dynamic stabilization: magnetic resonance image evaluation with a mean followup of four years. Adv Orthop. 2013;2013:437570.CrossRefPubMedPubMedCentral
48.
Cho BY, Murovic J, Park KW, Park J. Lumbar disc rehydration postimplantation of a posterior dynamic stabilization system. J Neurosurg Spine. 2010;13(5):576–80.CrossRefPubMed
49.
Luo L, Zhang C, Zhou Q, Zhao C, Wang L, Liang L, Tu B, Ouyang B, Gan Y. Effectiveness of transpedicular dynamic stabilization in treating discogenic low back pain. World Neurosurg. 2018;111:e192–e8.CrossRefPubMed
50.
Rudert M, Tillmann B. Detection of lymph and blood vessels in the human intervertebral disc by histochemical and immunohistochemical methods. Ann Anat. 1993;175(3):237–42.CrossRefPubMed
51.
Hassler O. The human intervertebral disc. A micro-angiographical study on its vascular supply at various ages. Acta Orthop Scand. 1969;40(6):765–72.CrossRefPubMed
52.
Urban JP, Smith S, Fairbank JC. Nutrition of the intervertebral disc. Spine (Phila Pa 1976). 2004;29(23):2700–9.CrossRef
53.
Whalen JL, Parke WW, Mazur JM, Stauffer ES. The intrinsic vasculature of developing vertebral end plates and its nutritive significance to the intervertebral discs. J Pediatr Orthop. 1985;5(4):403–10.CrossRefPubMed
54.
Bernick S, Cailliet R. Vertebral end-plate changes with aging of human vertebrae. Spine (Phila Pa 1976). 1982;7(2):97–102.CrossRef
55.
Aguiar DJ, Johnson SL, Oegema TR. Notochordal cells interact with nucleus pulposus cells: regulation of proteoglycan synthesis. Exp Cell Res. 1999;246(1):129–37.CrossRefPubMed
Metadata
Title
Calcification of the intervertebral disc and ossification of posterior longitudinal ligament in children
Authors
Jun-Jie Du
Yu-Fei Chen
Ye Peng
Xiao-jie Li
Wei Ma
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2018
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-018-2227-z

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