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Published in: BMC Musculoskeletal Disorders 1/2017

Open Access 01-12-2017 | Research article

Paradoxical tunnel enlargement after ACL reconstruction with hamstring autografts when using β-TCP containing interference screws for tibial aperture fixation- prospectively comparative study

Authors: Joon Ho Wang, Eun Su Lee, Byung Hoon Lee

Published in: BMC Musculoskeletal Disorders | Issue 1/2017

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Abstract

Background

Tibial aperture fixation with a bioabsorbable interference screw is a popular fixation method in anterior cruciate ligament reconstruction (ACLR). An interference screw containing β-tricalcium phosphate (β-TCP) to improve bony integration and biocompatibility was recently introduced. This study aims to compare the clinical outcomes and radiological results of tunnel enlargement effect between the 2 bioabsorbable fixative devices of pure poly-L-lactic acid (PLLA) interference screws and β-TCP-containing screws, for tibial interference fixation in ACLR using hamstring autografts.

Methods

Eighty consecutive patients who had undergone double-bundle ACLR between 2011 to 2012 were prospectively reviewed and randomly divided into two groups based on the type of tibial interference screw: 28 were assigned to the pure PLLA screw group (Group A), while the other 29 were assigned to the β-TCP-containing screw fixation group (Group B). Clinical evaluations and radiological analyses were conducted in both groups with a minimum 2- year follow-up.

Results

There was no significant difference in subjective or objective clinical outcome between the 2 groups. In radiological analyses, the use of a β-TCP-containing screw reduced tunnel widening in the portion of the tunnel with screw engagement compared to the pure PLLA screw, while the use of a β-TCP-containing screw resulted in greater tunnel enlargement in the proximal portion of the tunnel without screw engagement than use of a pure PLLA screw.

Conclusion

Use of a β-TCP-containing interference screw in tibial aperture fixation reduced tunnel enlargement in the vicinity of the screw, whereas greater enlargement occurred proximal to the screw end relative to use of a pure PLLA interference screw. These paradoxical enlargements in use of β-TCP containing screws suggest that for reducing tunnel enlargement, the length of the interference screw should be as fit as possible with tunnel length in terms of using soft grafts.
Level of Evidence: II, Prospectively comparative study.

Trial registration

Retrospectively registered with ClinicalTrials.gov. (NCT02754674), Date of trial registration: February 10, 2016.
Appendix
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Literature
1.
go back to reference McGuire DA, Barber FA, Elrod BF, Paulos LE. Bioabsorbable interference screws for graft fixation in anterior cruciate ligament reconstruction. Arthroscopy. 1999;15:463–73.CrossRefPubMed McGuire DA, Barber FA, Elrod BF, Paulos LE. Bioabsorbable interference screws for graft fixation in anterior cruciate ligament reconstruction. Arthroscopy. 1999;15:463–73.CrossRefPubMed
2.
go back to reference Barber FA. Flipped patellar tendon autograft anterior cruciate ligament reconstruction. Arthroscopy. 2000;16:483–90.CrossRefPubMed Barber FA. Flipped patellar tendon autograft anterior cruciate ligament reconstruction. Arthroscopy. 2000;16:483–90.CrossRefPubMed
3.
go back to reference Drogset JO, Grontvedt T, Tegnander A. Endoscopic reconstruction of the anterior cruciate ligament using bone-patellar tendon-bone grafts fixed with bioabsorbable or metal interference screws: a prospective randomized study of the clinical outcome. Am J Sports Med. 2005;33:1160–5.CrossRefPubMed Drogset JO, Grontvedt T, Tegnander A. Endoscopic reconstruction of the anterior cruciate ligament using bone-patellar tendon-bone grafts fixed with bioabsorbable or metal interference screws: a prospective randomized study of the clinical outcome. Am J Sports Med. 2005;33:1160–5.CrossRefPubMed
4.
go back to reference Kaeding C, Farr J, Kavanaugh T, Pedroza A. A prospective randomized comparison of bioabsorbable and titanium anterior cruciate ligament interference screws. Arthroscopy. 2005;21:147–51.CrossRefPubMed Kaeding C, Farr J, Kavanaugh T, Pedroza A. A prospective randomized comparison of bioabsorbable and titanium anterior cruciate ligament interference screws. Arthroscopy. 2005;21:147–51.CrossRefPubMed
5.
go back to reference Laxdal G, Kartus J, Eriksson BI, Faxen E, Sernert N, Karlsson J. Biodegradable and metallic interference screws in anterior cruciate ligament reconstruction surgery using hamstring tendon grafts: prospective randomized study of radiographic results and clinical outcome. Am J Sports Med. 2006;34:1574–80.CrossRefPubMed Laxdal G, Kartus J, Eriksson BI, Faxen E, Sernert N, Karlsson J. Biodegradable and metallic interference screws in anterior cruciate ligament reconstruction surgery using hamstring tendon grafts: prospective randomized study of radiographic results and clinical outcome. Am J Sports Med. 2006;34:1574–80.CrossRefPubMed
6.
go back to reference Barber FA, Dockery WD. Long-term absorption of poly-L-lactic acid interference screws. Arthroscopy. 2006;22:820–6.CrossRefPubMed Barber FA, Dockery WD. Long-term absorption of poly-L-lactic acid interference screws. Arthroscopy. 2006;22:820–6.CrossRefPubMed
7.
go back to reference Ma CB, Francis K, Towers J, Irrgang J, Fu FH, Harner CH. Hamstring anterior cruciate ligament reconstruction: a comparison of bioabsorbable interference screw and endobutton-post fixation. Arthroscopy. 2004;20:122–8.CrossRefPubMed Ma CB, Francis K, Towers J, Irrgang J, Fu FH, Harner CH. Hamstring anterior cruciate ligament reconstruction: a comparison of bioabsorbable interference screw and endobutton-post fixation. Arthroscopy. 2004;20:122–8.CrossRefPubMed
8.
go back to reference Warden WH, Chooljian D, Jackson DW. Ten-year magnetic resonance imaging follow-up of bioabsorbable poly-L-lactic acid interference screws after anterior cruciate ligament reconstruction. Arthroscopy. 2008;24(370):e371–3. Warden WH, Chooljian D, Jackson DW. Ten-year magnetic resonance imaging follow-up of bioabsorbable poly-L-lactic acid interference screws after anterior cruciate ligament reconstruction. Arthroscopy. 2008;24(370):e371–3.
9.
go back to reference Bourke HE, Salmon LJ, Waller A, Winalski CS, Williams HA, Linklater JM, Vasanji A, Roe JP, Pinczewski LA. Randomized controlled trial of osteoconductive fixation screws for anterior cruciate ligament reconstruction: a comparison of the Calaxo and Milagro screws. Arthroscopy. 2013;29:74–82.CrossRefPubMed Bourke HE, Salmon LJ, Waller A, Winalski CS, Williams HA, Linklater JM, Vasanji A, Roe JP, Pinczewski LA. Randomized controlled trial of osteoconductive fixation screws for anterior cruciate ligament reconstruction: a comparison of the Calaxo and Milagro screws. Arthroscopy. 2013;29:74–82.CrossRefPubMed
10.
go back to reference Foldager C, Jakobsen BW, Lund B, Christiansen SE, Kashi L, Mikkelsen LR, Lind M. Tibial tunnel widening after bioresorbable poly-lactide calcium carbonate interference screw usage in ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2010;18:79–84.CrossRefPubMed Foldager C, Jakobsen BW, Lund B, Christiansen SE, Kashi L, Mikkelsen LR, Lind M. Tibial tunnel widening after bioresorbable poly-lactide calcium carbonate interference screw usage in ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2010;18:79–84.CrossRefPubMed
11.
go back to reference Moisala AS, Jarvela T, Paakkala A, Paakkala T, Kannus P, Jarvinen M. Comparison of the bioabsorbable and metal screw fixation after ACL reconstruction with a hamstring autograft in MRI and clinical outcome: a prospective randomized study. Knee Surg Sports Traumatol Arthrosc. 2008;16:1080–6.CrossRefPubMed Moisala AS, Jarvela T, Paakkala A, Paakkala T, Kannus P, Jarvinen M. Comparison of the bioabsorbable and metal screw fixation after ACL reconstruction with a hamstring autograft in MRI and clinical outcome: a prospective randomized study. Knee Surg Sports Traumatol Arthrosc. 2008;16:1080–6.CrossRefPubMed
12.
go back to reference Doig GS, Simpson F. Randomization and allocation concealment: a practical guide for researchers. J Crit Care. 2005;20:187–91. discussion 191-183CrossRefPubMed Doig GS, Simpson F. Randomization and allocation concealment: a practical guide for researchers. J Crit Care. 2005;20:187–91. discussion 191-183CrossRefPubMed
13.
go back to reference Carulli C, Matassi F, Soderi S, Sirleo L, Munz G, Innocenti M. Resorbable screw and sheath versus resorbable interference screw and staples for ACL reconstruction: a comparison of two tibial fixation methods. Knee Surg Sports Traumatol Arthrosc. 2017;25(4):1264–71.CrossRefPubMed Carulli C, Matassi F, Soderi S, Sirleo L, Munz G, Innocenti M. Resorbable screw and sheath versus resorbable interference screw and staples for ACL reconstruction: a comparison of two tibial fixation methods. Knee Surg Sports Traumatol Arthrosc. 2017;25(4):1264–71.CrossRefPubMed
14.
go back to reference Ahn JH, Wang JH, Lee YS, Kim JG, Kang JH, Koh KH. Anterior cruciate ligament reconstruction using remnant preservation and a femoral tensioning technique: clinical and magnetic resonance imaging results. Arthroscopy. 2011;27:1079–89.CrossRefPubMed Ahn JH, Wang JH, Lee YS, Kim JG, Kang JH, Koh KH. Anterior cruciate ligament reconstruction using remnant preservation and a femoral tensioning technique: clinical and magnetic resonance imaging results. Arthroscopy. 2011;27:1079–89.CrossRefPubMed
15.
go back to reference Hanley ST, Warren RF. Arthroscopic meniscectomy in the anterior cruciate ligament-deficient knee. Arthroscopy. 1987;3:59–65.CrossRefPubMed Hanley ST, Warren RF. Arthroscopic meniscectomy in the anterior cruciate ligament-deficient knee. Arthroscopy. 1987;3:59–65.CrossRefPubMed
16.
go back to reference Buss DD, Warren RF, Wickiewicz TL, Galinat BJ, Panariello R. Arthroscopically assisted reconstruction of the anterior cruciate ligament with use of autogenous patellar-ligament grafts. Results after twenty-four to forty-two months. J Bone Joint Surg Am. 1993;75:1346–55.CrossRefPubMed Buss DD, Warren RF, Wickiewicz TL, Galinat BJ, Panariello R. Arthroscopically assisted reconstruction of the anterior cruciate ligament with use of autogenous patellar-ligament grafts. Results after twenty-four to forty-two months. J Bone Joint Surg Am. 1993;75:1346–55.CrossRefPubMed
17.
go back to reference Iorio R, Vadala A, Argento G, Di Sanzo V, Ferretti A. Bone tunnel enlargement after ACL reconstruction using autologous hamstring tendons: a CT study. Int Orthop. 2007;31:49–55.CrossRefPubMed Iorio R, Vadala A, Argento G, Di Sanzo V, Ferretti A. Bone tunnel enlargement after ACL reconstruction using autologous hamstring tendons: a CT study. Int Orthop. 2007;31:49–55.CrossRefPubMed
18.
go back to reference Aga C, Wilson KJ, Johansen S, Dornan G, La Prade RF, Engebretsen L. Tunnel widening in single- versus double-bundle anterior cruciate ligament reconstructed knees. Knee Surg Sports Traumatol Arthrosc. 2017;25:1316–27.CrossRefPubMed Aga C, Wilson KJ, Johansen S, Dornan G, La Prade RF, Engebretsen L. Tunnel widening in single- versus double-bundle anterior cruciate ligament reconstructed knees. Knee Surg Sports Traumatol Arthrosc. 2017;25:1316–27.CrossRefPubMed
19.
go back to reference Nebelung W, Becker R, Merkel M, Ropke M. Bone tunnel enlargement after anterior cruciate ligament reconstruction with semitendinosus tendon using Endobutton fixation on the femoral side. Arthroscopy. 1998;14:810–5.CrossRefPubMed Nebelung W, Becker R, Merkel M, Ropke M. Bone tunnel enlargement after anterior cruciate ligament reconstruction with semitendinosus tendon using Endobutton fixation on the femoral side. Arthroscopy. 1998;14:810–5.CrossRefPubMed
20.
go back to reference Hovis WD, Bucholz RW. Polyglycolide bioabsorbable screws in the treatment of ankle fractures. Foot Ankle Int. 1997;18:128–31.CrossRefPubMed Hovis WD, Bucholz RW. Polyglycolide bioabsorbable screws in the treatment of ankle fractures. Foot Ankle Int. 1997;18:128–31.CrossRefPubMed
21.
go back to reference Stahelin AC, Weiler A, Rufenacht H, Hoffmann R, Geissmann A, Feinstein R. Clinical degradation and biocompatibility of different bioabsorbable interference screws: a report of six cases. Arthroscopy. 1997;13:238–44.CrossRefPubMed Stahelin AC, Weiler A, Rufenacht H, Hoffmann R, Geissmann A, Feinstein R. Clinical degradation and biocompatibility of different bioabsorbable interference screws: a report of six cases. Arthroscopy. 1997;13:238–44.CrossRefPubMed
22.
go back to reference Bergsma JE, de Bruijn WC, Rozema FR, Bos RR, Boering G. Late degradation tissue response to poly(L-lactide) bone plates and screws. Biomaterials. 1995;16:25–31.CrossRefPubMed Bergsma JE, de Bruijn WC, Rozema FR, Bos RR, Boering G. Late degradation tissue response to poly(L-lactide) bone plates and screws. Biomaterials. 1995;16:25–31.CrossRefPubMed
23.
go back to reference Lajtai G, Noszian I, Humer K, Unger F, Aitzetmuller G, Orthner E. Serial magnetic resonance imaging evaluation of operative site after fixation of patellar tendon graft with bioabsorbable interference screws in anterior cruciate ligament reconstruction. Arthroscopy. 1999;15:709–18.CrossRefPubMed Lajtai G, Noszian I, Humer K, Unger F, Aitzetmuller G, Orthner E. Serial magnetic resonance imaging evaluation of operative site after fixation of patellar tendon graft with bioabsorbable interference screws in anterior cruciate ligament reconstruction. Arthroscopy. 1999;15:709–18.CrossRefPubMed
24.
go back to reference Lajtai G, Humer K, Aitzetmuller G, Unger F, Noszian I, Orthner E. Serial magnetic resonance imaging evaluation of a bioabsorbable interference screw and the adjacent bone. Arthroscopy. 1999;15:481–8.CrossRefPubMed Lajtai G, Humer K, Aitzetmuller G, Unger F, Noszian I, Orthner E. Serial magnetic resonance imaging evaluation of a bioabsorbable interference screw and the adjacent bone. Arthroscopy. 1999;15:481–8.CrossRefPubMed
25.
go back to reference Aga C, Rasmussen MT, Smith SD, Jansson KS, LaPrade RF, Engebretsen L, Wijdicks CA. Biomechanical comparison of interference screws and combination screw and sheath devices for soft tissue anterior cruciate ligament reconstruction on the tibial side. Am J Sports Med. 2013;41:841–8.CrossRefPubMed Aga C, Rasmussen MT, Smith SD, Jansson KS, LaPrade RF, Engebretsen L, Wijdicks CA. Biomechanical comparison of interference screws and combination screw and sheath devices for soft tissue anterior cruciate ligament reconstruction on the tibial side. Am J Sports Med. 2013;41:841–8.CrossRefPubMed
26.
go back to reference Kamitakahara M, Ohtsuki C, Miyazaki T. Review paper: behavior of ceramic biomaterials derived from tricalcium phosphate in physiological condition. J Biomater Appl. 2008;23:197–212.CrossRefPubMed Kamitakahara M, Ohtsuki C, Miyazaki T. Review paper: behavior of ceramic biomaterials derived from tricalcium phosphate in physiological condition. J Biomater Appl. 2008;23:197–212.CrossRefPubMed
27.
go back to reference Honda Y, Kamakura S, Sasaki K, Suzuki O. Formation of bone-like apatite enhanced by hydrolysis of octacalcium phosphate crystals deposited in collagen matrix. J Biomed Mater Res B Appl Biomater. 2007;80:281–9.CrossRefPubMed Honda Y, Kamakura S, Sasaki K, Suzuki O. Formation of bone-like apatite enhanced by hydrolysis of octacalcium phosphate crystals deposited in collagen matrix. J Biomed Mater Res B Appl Biomater. 2007;80:281–9.CrossRefPubMed
28.
go back to reference Okuda T, Ioku K, Yonezawa I, Minagi H, Kawachi G, Gonda Y, Murayama H, Shibata Y, Minami S, Kamihira S, Kurosawa H, Ikeda T. The effect of the microstructure of beta-tricalcium phosphate on the metabolism of subsequently formed bone tissue. Biomaterials. 2007;28:2612–21.CrossRefPubMed Okuda T, Ioku K, Yonezawa I, Minagi H, Kawachi G, Gonda Y, Murayama H, Shibata Y, Minami S, Kamihira S, Kurosawa H, Ikeda T. The effect of the microstructure of beta-tricalcium phosphate on the metabolism of subsequently formed bone tissue. Biomaterials. 2007;28:2612–21.CrossRefPubMed
29.
go back to reference Agrawal CM, Athanasiou KA. Technique to control pH in vicinity of biodegrading PLA-PGA implants. J Biomed Mater Res. 1997;38:105–14.CrossRefPubMed Agrawal CM, Athanasiou KA. Technique to control pH in vicinity of biodegrading PLA-PGA implants. J Biomed Mater Res. 1997;38:105–14.CrossRefPubMed
30.
go back to reference Braux J, Velard F, Guillaume C, Bouthors S, Jallot E, Nedelec JM, Laurent-Maquin D, Laquerriere P. A new insight into the dissociating effect of strontium on bone resorption and formation. Acta Biomater. 2011;7:2593–603.CrossRefPubMed Braux J, Velard F, Guillaume C, Bouthors S, Jallot E, Nedelec JM, Laurent-Maquin D, Laquerriere P. A new insight into the dissociating effect of strontium on bone resorption and formation. Acta Biomater. 2011;7:2593–603.CrossRefPubMed
31.
go back to reference Penolazzi L, Lambertini E, Tavanti E, Torreggiani E, Vesce F, Gambari R, Piva R. Evaluation of chemokine and cytokine profiles in osteoblast progenitors from umbilical cord blood stem cells by BIO-PLEX technology. Cell Biol Int. 2008;32:320–5.CrossRefPubMed Penolazzi L, Lambertini E, Tavanti E, Torreggiani E, Vesce F, Gambari R, Piva R. Evaluation of chemokine and cytokine profiles in osteoblast progenitors from umbilical cord blood stem cells by BIO-PLEX technology. Cell Biol Int. 2008;32:320–5.CrossRefPubMed
32.
go back to reference Lisignoli G, Toneguzzi S, Pozzi C, Piacentini A, Riccio M, Ferruzzi A, Gualtieri G, Facchini A. Proinflammatory cytokines and chemokine production and expression by human osteoblasts isolated from patients with rheumatoid arthritis and osteoarthritis. J Rheumatol. 1999;26:791–9.PubMed Lisignoli G, Toneguzzi S, Pozzi C, Piacentini A, Riccio M, Ferruzzi A, Gualtieri G, Facchini A. Proinflammatory cytokines and chemokine production and expression by human osteoblasts isolated from patients with rheumatoid arthritis and osteoarthritis. J Rheumatol. 1999;26:791–9.PubMed
33.
go back to reference McGuire DA, Barber FA, Milchgrub S, Wolchok JC. A postmortem examination of poly-L lactic acid interference screws 4 months after implantation during anterior cruciate ligament reconstruction. Arthroscopy. 2001;17:988–92.CrossRefPubMed McGuire DA, Barber FA, Milchgrub S, Wolchok JC. A postmortem examination of poly-L lactic acid interference screws 4 months after implantation during anterior cruciate ligament reconstruction. Arthroscopy. 2001;17:988–92.CrossRefPubMed
34.
go back to reference Martinek V, Seil R, Lattermann C, Watkins SC, Fu FH. The fate of the poly-L-lactic acid interference screw after anterior cruciate ligament reconstruction. Arthroscopy. 2001;17:73–6.CrossRefPubMed Martinek V, Seil R, Lattermann C, Watkins SC, Fu FH. The fate of the poly-L-lactic acid interference screw after anterior cruciate ligament reconstruction. Arthroscopy. 2001;17:73–6.CrossRefPubMed
35.
go back to reference Jarvela T, Moisala AS, Paakkala T, Paakkala A. Tunnel enlargement after double-bundle anterior cruciate ligament reconstruction: a prospective, randomized study. Arthroscopy. 2008;24:1349–57.CrossRefPubMed Jarvela T, Moisala AS, Paakkala T, Paakkala A. Tunnel enlargement after double-bundle anterior cruciate ligament reconstruction: a prospective, randomized study. Arthroscopy. 2008;24:1349–57.CrossRefPubMed
36.
go back to reference Lee YS, Lee SW, Nam SW, Oh WS, Sim JA, Kwak JH, Lee BK. Analysis of tunnel widening after double-bundle ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2012;20:2243–50.CrossRefPubMed Lee YS, Lee SW, Nam SW, Oh WS, Sim JA, Kwak JH, Lee BK. Analysis of tunnel widening after double-bundle ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2012;20:2243–50.CrossRefPubMed
37.
go back to reference Siebold R, Cafaltzis K. Differentiation between intraoperative and postoperative bone tunnel widening and communication in double-bundle anterior cruciate ligament reconstruction: a prospective study. Arthroscopy. 2010;26:1066–73.CrossRefPubMed Siebold R, Cafaltzis K. Differentiation between intraoperative and postoperative bone tunnel widening and communication in double-bundle anterior cruciate ligament reconstruction: a prospective study. Arthroscopy. 2010;26:1066–73.CrossRefPubMed
38.
go back to reference Lind M, Feller J, Webster KE. Bone tunnel widening after anterior cruciate ligament reconstruction using EndoButton or EndoButton continuous loop. Arthroscopy. 2009;25:1275–80.CrossRefPubMed Lind M, Feller J, Webster KE. Bone tunnel widening after anterior cruciate ligament reconstruction using EndoButton or EndoButton continuous loop. Arthroscopy. 2009;25:1275–80.CrossRefPubMed
39.
go back to reference Hoher J, Moller HD, Fu FH. Bone tunnel enlargement after anterior cruciate ligament reconstruction: fact or fiction? Knee Surg Sports Traumatol Arthrosc. 1998;6:231–40.CrossRefPubMed Hoher J, Moller HD, Fu FH. Bone tunnel enlargement after anterior cruciate ligament reconstruction: fact or fiction? Knee Surg Sports Traumatol Arthrosc. 1998;6:231–40.CrossRefPubMed
Metadata
Title
Paradoxical tunnel enlargement after ACL reconstruction with hamstring autografts when using β-TCP containing interference screws for tibial aperture fixation- prospectively comparative study
Authors
Joon Ho Wang
Eun Su Lee
Byung Hoon Lee
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2017
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-017-1757-0

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