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Published in: BMC Public Health 1/2019

Open Access 01-12-2019 | Breast Cancer | Research article

Determinants of breast cancer in Saudi women from Makkah region: a case-control study (breast cancer risk factors among Saudi women)

Authors: Fatmah J. Alsolami, Firas S. Azzeh, Khloud J. Ghafouri, Mazen M. Ghaith, Riyad A. Almaimani, Hussain A. Almasmoum, Rwaa H. Abdulal, Wesam H. Abdulaal, Abdelelah S. Jazar, Sufyan H. Tashtoush

Published in: BMC Public Health | Issue 1/2019

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Abstract

Background

There are various factors that play a major role in influencing the overall health conditions of women diagnosed with breast cancer. The population of women in Makkah region are diverse, therefore it is significant to highlight the possible determinants of breast cancer in this population. This is a case-control study that assessed determinants of breast cancer including socioeconomic factors, health-related characteristics, menstrual histories and breastfeeding among postmenopausal women in Makkah region in Saudi Arabia.

Methods

A total of 432 female participants (214 cases and 218 controls) were recruited for this study. A validated questionnaire was completed by trained dietitians at King Abdullah Medical City Hospital in the Makkah region of Saudi Arabia.

Results

Results displayed that determinants of breast cancer were associated significantly (P < 0.05) with unemployment, large family size, lack of knowledge and awareness about breast cancer, obesity, sedentary lifestyle, smoking, starting menarche at an early age, as well as hormonal and non-hormonal contraceptive use. There was no effect of diabetes, hypertension, hyperlipidemia, and duration of breastfeeding on the incidence of breast cancer.

Conclusion

In summary, the results of this study accentuate the possible effect of socioeconomic factors, health-related characteristics and menstrual history on the incidence of breast cancer in postmenopausal women in the Makkah region. Education programs should be applied to increase breast cancer awareness and possibly decrease its incidence.
Literature
1.
go back to reference Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global Cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.CrossRef Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global Cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.CrossRef
3.
go back to reference McPherson K, Steel C, Dixon S. Breast cancer-epidemioloy, risk factors genetics. BMJ. 2000;321:624–8.CrossRef McPherson K, Steel C, Dixon S. Breast cancer-epidemioloy, risk factors genetics. BMJ. 2000;321:624–8.CrossRef
4.
go back to reference Davies N, Batehup L, Thomas R. The role of diet and physical activity in breast, colorectal, and prostate Cancer survivorship: a review of the literature. Br J Cancer. 2011;8:105. Davies N, Batehup L, Thomas R. The role of diet and physical activity in breast, colorectal, and prostate Cancer survivorship: a review of the literature. Br J Cancer. 2011;8:105.
5.
go back to reference Surakasula A, Nagarjunapu GC, Raghavaiah KV. A comparative study of pre- and post-menopausal breast cancer: risk factors, presentation, characteristics and management. J Res Pharm Pract. 2014;3:12–8.CrossRef Surakasula A, Nagarjunapu GC, Raghavaiah KV. A comparative study of pre- and post-menopausal breast cancer: risk factors, presentation, characteristics and management. J Res Pharm Pract. 2014;3:12–8.CrossRef
6.
go back to reference Alford SH, Schwartz K, Soliman A, et al. Breast cancer characteristics at diagnosis and survival among Arab-American women compared to European- and African American women. Breast Cancer Res Treat. 2009;114:339–46.CrossRef Alford SH, Schwartz K, Soliman A, et al. Breast cancer characteristics at diagnosis and survival among Arab-American women compared to European- and African American women. Breast Cancer Res Treat. 2009;114:339–46.CrossRef
7.
go back to reference Hemminki K, Mosuavi SM, Sundquist J, Brandt A. Does the breast Cancer age at diagnosis differ by ethnicity? A study on immigrants to Sweden. Oncologist. 2011;16:146–54.CrossRef Hemminki K, Mosuavi SM, Sundquist J, Brandt A. Does the breast Cancer age at diagnosis differ by ethnicity? A study on immigrants to Sweden. Oncologist. 2011;16:146–54.CrossRef
8.
go back to reference Wilson LF, Page AN, Dunn NA, Pandeya N, Protani MM, Taylor RJ. Population attributable risk of modifiable risk factors associated with invasive breast cancer in women aged 45-69 years in Queensland, Australia. Maturitas. 2013;76:370–6.CrossRef Wilson LF, Page AN, Dunn NA, Pandeya N, Protani MM, Taylor RJ. Population attributable risk of modifiable risk factors associated with invasive breast cancer in women aged 45-69 years in Queensland, Australia. Maturitas. 2013;76:370–6.CrossRef
9.
go back to reference Narod S. Women with Cancer in low-income countries. Curr Oncol. 2017;24:217–9.CrossRef Narod S. Women with Cancer in low-income countries. Curr Oncol. 2017;24:217–9.CrossRef
10.
go back to reference Bcheraoui C, Basulaiman M, Wilson S, et al. Breast Cancer screening in Saudi arabia: free but almost no takers. PLoS One. 2015;10:e0119051.CrossRef Bcheraoui C, Basulaiman M, Wilson S, et al. Breast Cancer screening in Saudi arabia: free but almost no takers. PLoS One. 2015;10:e0119051.CrossRef
11.
go back to reference Trieu PDY, Mello-Thoms C, Peat J, Do T, Brennan P. Risk factors of female breast Cancer in Vietnam: a case-control study. Cancer Res Treat. 2017;49:990.CrossRef Trieu PDY, Mello-Thoms C, Peat J, Do T, Brennan P. Risk factors of female breast Cancer in Vietnam: a case-control study. Cancer Res Treat. 2017;49:990.CrossRef
12.
go back to reference Azzeh FS. Determinants of exclusive breastfeeding and patterns of complementary feeding practices in Mecca City, Saudi Arabia. Int J Child Health Nutr. 2017;6:80–9.CrossRef Azzeh FS. Determinants of exclusive breastfeeding and patterns of complementary feeding practices in Mecca City, Saudi Arabia. Int J Child Health Nutr. 2017;6:80–9.CrossRef
13.
go back to reference Newcomb PA, Egan KM, Titus-Ernstoff L, Trentham-Dietz A, Greenberg ER, Baron JA, Willett WC, Stampfer MJ. Lactation in relation to postmenopausal breast cancer. Am J Epidemiol. 1999;150:174–82.CrossRef Newcomb PA, Egan KM, Titus-Ernstoff L, Trentham-Dietz A, Greenberg ER, Baron JA, Willett WC, Stampfer MJ. Lactation in relation to postmenopausal breast cancer. Am J Epidemiol. 1999;150:174–82.CrossRef
14.
go back to reference Al Otaibi S, Al Harbi M, Al Kahmoas A, et al. General breast Cancer awareness among women in Riyadh City. Asian Pac J Cancer Prev. 2017;18:159–63.PubMedPubMedCentral Al Otaibi S, Al Harbi M, Al Kahmoas A, et al. General breast Cancer awareness among women in Riyadh City. Asian Pac J Cancer Prev. 2017;18:159–63.PubMedPubMedCentral
15.
go back to reference Simmons R, Cosgrove SC, Romney MC, et al. Health literacy: Cancer prevention strategies for early adults. Am J Prev Med. 2017;53:S73–7.CrossRef Simmons R, Cosgrove SC, Romney MC, et al. Health literacy: Cancer prevention strategies for early adults. Am J Prev Med. 2017;53:S73–7.CrossRef
16.
go back to reference Patel K, Kanu M, Liu J, et al. Factors influencing breast Cancer screening in low-income African Americans in Tennessee. J Community Health. 2014;39:943–50.CrossRef Patel K, Kanu M, Liu J, et al. Factors influencing breast Cancer screening in low-income African Americans in Tennessee. J Community Health. 2014;39:943–50.CrossRef
17.
go back to reference Bertoglia MP, Gormaz JG, Libuy M, et al. The population impact of obesity, sedentary lifestyle, and tobacco and alcohol consumption on the prevalence of type 2 diabetes: analysis of a health population survey in Chile, 2010. PLoS One. 2017;12:e0178092.CrossRef Bertoglia MP, Gormaz JG, Libuy M, et al. The population impact of obesity, sedentary lifestyle, and tobacco and alcohol consumption on the prevalence of type 2 diabetes: analysis of a health population survey in Chile, 2010. PLoS One. 2017;12:e0178092.CrossRef
18.
go back to reference Sun L, Zhu Y, Qian Q, Tang L. Body mass index and prognosis of breast cancer. Medicine (Baltimore). 2018;97:26. Sun L, Zhu Y, Qian Q, Tang L. Body mass index and prognosis of breast cancer. Medicine (Baltimore). 2018;97:26.
19.
go back to reference Queiroz SA, de Sousa I, Silva F, et al. Nutritional and environmental risk factors for breast Cancer: a case-control study. Sci Med. 2018;28:ID28723.CrossRef Queiroz SA, de Sousa I, Silva F, et al. Nutritional and environmental risk factors for breast Cancer: a case-control study. Sci Med. 2018;28:ID28723.CrossRef
20.
go back to reference Picon-Ruiz M, Morata-Tarifa C, Valle-Goffin JJ, Friedman ER, Slingerland JM. Obesity and adverse breast Cancer risk and outcome: mechanistic insights and strategies for intervention. CA Cancer J Clin. 2017;67:378–97.CrossRef Picon-Ruiz M, Morata-Tarifa C, Valle-Goffin JJ, Friedman ER, Slingerland JM. Obesity and adverse breast Cancer risk and outcome: mechanistic insights and strategies for intervention. CA Cancer J Clin. 2017;67:378–97.CrossRef
21.
go back to reference Kim S, Cho Y, Kim S. Weight gain and its correlates among breast Cancer survivors. Asian Nurs Res. 2013;7:161–7.CrossRef Kim S, Cho Y, Kim S. Weight gain and its correlates among breast Cancer survivors. Asian Nurs Res. 2013;7:161–7.CrossRef
22.
go back to reference Alshaikh M, Filippidis F, Al-Omar H, et al. The ticking time bomb in lifestyle-related diseases among women in the Gulf cooperation council countries: review of systematic review. BMC Public Health. 2017;17:536.CrossRef Alshaikh M, Filippidis F, Al-Omar H, et al. The ticking time bomb in lifestyle-related diseases among women in the Gulf cooperation council countries: review of systematic review. BMC Public Health. 2017;17:536.CrossRef
23.
go back to reference Azzeh F, Bukhari HM, Header EA, et al. Trends in overweight or obesity and other anthropometric indices in adults aged 18-60 years in Westren Saudi Arabia. Ann Saudi Med. 2017;37:106–13.CrossRef Azzeh F, Bukhari HM, Header EA, et al. Trends in overweight or obesity and other anthropometric indices in adults aged 18-60 years in Westren Saudi Arabia. Ann Saudi Med. 2017;37:106–13.CrossRef
24.
go back to reference Lee IM. Physical activity and Cancer prevention-data from epidemiologic studies. Med Sci Sports Exerc. 2003;35:1823–7.CrossRef Lee IM. Physical activity and Cancer prevention-data from epidemiologic studies. Med Sci Sports Exerc. 2003;35:1823–7.CrossRef
25.
go back to reference Friedenreich C, Cust A. Physical activity and breast Cancer risk: impact of timing, type and dose of activity and population subgroup effects. Br J Sports Med. 2008;42:636–47.CrossRef Friedenreich C, Cust A. Physical activity and breast Cancer risk: impact of timing, type and dose of activity and population subgroup effects. Br J Sports Med. 2008;42:636–47.CrossRef
26.
go back to reference Al-Hazaa H. The public health burden of physical inactivity in Saudi Arabia. J Fam Community Med. 2004;11:45–51. Al-Hazaa H. The public health burden of physical inactivity in Saudi Arabia. J Fam Community Med. 2004;11:45–51.
27.
go back to reference Albawardi N, Jradi H, Almalki AA, Al-Hazzaa HM. Level of sedentary behavior and its associated factors among Saudi women working in office-based jobs in Saudi Arabia. Int J Environ Res Public Health. 2017;14:659.CrossRef Albawardi N, Jradi H, Almalki AA, Al-Hazzaa HM. Level of sedentary behavior and its associated factors among Saudi women working in office-based jobs in Saudi Arabia. Int J Environ Res Public Health. 2017;14:659.CrossRef
28.
go back to reference Kispert S, McHowat J. Recent insights into cigarette smoking as a lifestyle risk factor for breast cancer. Breast Cancer Targets Ther. 2017;9:127–32.CrossRef Kispert S, McHowat J. Recent insights into cigarette smoking as a lifestyle risk factor for breast cancer. Breast Cancer Targets Ther. 2017;9:127–32.CrossRef
29.
go back to reference Jones M, Schoemaker MJ, Wright LB, Ashworth A, Swerdlow AJ. Smoking and risk of breast Cancer in the generations study cohort. Breast Cancer Res. 2017;19:118.CrossRef Jones M, Schoemaker MJ, Wright LB, Ashworth A, Swerdlow AJ. Smoking and risk of breast Cancer in the generations study cohort. Breast Cancer Res. 2017;19:118.CrossRef
30.
go back to reference Colditz G, Bohlke K, Berkey C. Breast Cancer risk accumulation starts early: prevention must also. Breast Cancer Res. 2014;145:567–79.CrossRef Colditz G, Bohlke K, Berkey C. Breast Cancer risk accumulation starts early: prevention must also. Breast Cancer Res. 2014;145:567–79.CrossRef
31.
go back to reference Bodicoat DH, Schoemaker MJ, Jones ME, et al. Timing of pubertal stages and breast cancer risk: the breakthrough generations study. Breast Cancer Res. 2014;16:R18.CrossRef Bodicoat DH, Schoemaker MJ, Jones ME, et al. Timing of pubertal stages and breast cancer risk: the breakthrough generations study. Breast Cancer Res. 2014;16:R18.CrossRef
32.
go back to reference Collaborative Group on Hormonal Factors in Breast Cancer. Menarche, menopause, and breast Cancer risk: individual participant meta-analysis, including 118 964 women with breast Cancer from 117 epidemiological studies. Lancet Oncol. 2012;13:1141–51.CrossRef Collaborative Group on Hormonal Factors in Breast Cancer. Menarche, menopause, and breast Cancer risk: individual participant meta-analysis, including 118 964 women with breast Cancer from 117 epidemiological studies. Lancet Oncol. 2012;13:1141–51.CrossRef
33.
go back to reference Hunter D. Oral contraceptives and the small increased risk of breast Cancer. N Engl J Med. 2017;377:2276–7.CrossRef Hunter D. Oral contraceptives and the small increased risk of breast Cancer. N Engl J Med. 2017;377:2276–7.CrossRef
34.
go back to reference Morch L, Naftolin F, Keefe DL. Contemporary hormonal contraception and the risk of breast Cancer. N Engl J Med. 2018;378:1265.PubMed Morch L, Naftolin F, Keefe DL. Contemporary hormonal contraception and the risk of breast Cancer. N Engl J Med. 2018;378:1265.PubMed
35.
go back to reference Zolfaroli I, Tarin J, Cano A. Hormonal contraceptives and breast Cancer: clinical data. Eur J Obstet Gynecol Reprod Biol. 2018;230:212–6.CrossRef Zolfaroli I, Tarin J, Cano A. Hormonal contraceptives and breast Cancer: clinical data. Eur J Obstet Gynecol Reprod Biol. 2018;230:212–6.CrossRef
Metadata
Title
Determinants of breast cancer in Saudi women from Makkah region: a case-control study (breast cancer risk factors among Saudi women)
Authors
Fatmah J. Alsolami
Firas S. Azzeh
Khloud J. Ghafouri
Mazen M. Ghaith
Riyad A. Almaimani
Hussain A. Almasmoum
Rwaa H. Abdulal
Wesam H. Abdulaal
Abdelelah S. Jazar
Sufyan H. Tashtoush
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2019
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-019-7942-3

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