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Published in: BMC Public Health 1/2019

Open Access 01-12-2019 | Air Pollutants | Research article

Associations between ambient air pollution and cancer incidence in Taiwan: an ecological study of geographical variations

Authors: Shih-Yung Su, Yung-Po Liaw, Jing-Rong Jhuang, Shu-Yi Hsu, Chun-Ju Chiang, Ya-Wen Yang, Wen-Chung Lee

Published in: BMC Public Health | Issue 1/2019

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Abstract

Background

Air pollution is a global public health concern. The World Health Organization has recently set up a goal of saving 7 million people globally by 2030 from air pollution related death. We conducted an ecological study of geographical variation to explore the association between air pollution (specifically, particulate matter <2.5 μm in aerodynamic diameter [PM2.5], particulate matter <10 μm in aerodynamic diameter, sulfur dioxide, nitrogen dioxide, nitric oxide, and ozone) and cancer incidence in Taiwan, from 2012 to 2016.

Methods

In this study, the yearly average concentrations of each air pollutant at 75 air quality monitoring stations were calculated, and using the kriging method, the concentrations were extrapolated to each and every geographical central point of 349 local administrative areas of Taiwan. Spearman rank correlation coefficients between the age-adjusted cancer incidence rates and various air pollutants were calculated by stratifying genders and urbanization degrees of the local administrative areas. A total of 70 correlation coefficients were calculated.

Results

In total, 17 correlation coefficients were significantly positive at an alpha level of 0.05. Among these, four correlation coefficients between the age-adjusted cancer incidence rates and PM2.5 levels remained significant after Bonferroni correction. For men in developing towns, general towns, and aged towns and for women in aged towns, the age-adjusted cancer incidence rates increased 13.1 (95% confidence interval [CI], 8.8–17.6), 11 (95% CI, 5.6–16.4), 16.7 (95% CI, 6.9–26.4), and 11.9 (95% CI, 5.6–18.2) per 100,000 populations, respectively, for every 1 μg/m3 increment in PM2.5 concentrations.

Conclusions

A significantly positive correlation was observed between the PM2.5 level and cancer incidence rate after multiple testing correction.
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Literature
1.
2.
North CM, Rice MB, Ferkol T, Gozal D, Hui C, Jung SH, et al. Air pollution in the Asia-Pacific region. A joint Asian Pacific Society of Respirology/American Thoracic Society perspective. Am J Respir Crit Care Med. 2019;199(6):693–700.CrossRef
3.
Cicoira M. Ambient air pollution as a new risk factor for cardiovascular diseases: time to take action. Eur J Prev Cardiol. 2018;25(8):816–7.CrossRef
4.
Schraufnagel DE, Balmes JR, Cowl CT, De Matteis S, Jung SH, Mortimer K, et al. Air pollution and noncommunicable diseases: a review by the forum of international respiratory Societies’ environmental committee, part 2: air pollution and organ systems. Chest. 2019;155(2):417–26.CrossRef
5.
Turner MC, Krewski D, Diver WR, Pope CA, Burnett RT, Jerrett M, et al. Ambient air pollution and cancer mortality in the cancer prevention study II. Environ Health Perspect. 2017;125(8):087013.CrossRef
6.
Pedersen M, Andersen ZJ, Stafoggia M, Weinmayre G, Galassi C, Sorensen M, et al. Ambient air pollution and primary liver cancer incidence in four European cohorts within the ESCAPE project. Environ Res. 2017;154:226–33.CrossRef
7.
Chiang PH, Chen C, Hsieh D, Chan TC, Chiang HC, Wen CP. Lung cancer risk in females due to exposures to PM2.5 in Taiwan. Open Epidemiol J. 2014;7:6–16.CrossRef
8.
Tseng CH, Tsuang BJ, Chiang CJ, Ku KC, Tseng JS, Yang TY, et al. The relationship between air pollution and Lung cancer in nonsmokers in Taiwan. J Thorac Oncol. 2019;14(5):784–92.CrossRef
9.
Pan WC, Wu CD, Chen MJ, Huang YT, Chen CJ, Su HJ, et al. Fine particle pollution, alanine transaminase, and liver cancer: a Taiwanese prospective cohort study (REVEAL-HBV). Jnci-J Natl Cancer I. 2016;108(3):1.
10.
Hung LJ, Tsai SS, Chen PS, Yang YH, Liou SH, Wu TN, et al. Traffic air pollution and risk of death from breast cancer in Taiwan: fine particulate matter (PM2.5) as a proxy marker. Aerosol Air Qual Res. 2012;12(2):275–82.CrossRef
11.
Chu YH, Kao SW, Tantoh DM, Ko PC, Lan SJ, Liaw YP. Association between fine particulate matter and oral cancer among Taiwanese men. J Investig Med. 2019;67(1):34–8.CrossRef
12.
Hung LJ, Chan TF, Wu CH, Chiu HF, Yang CY. Traffic air pollution and risk of death from ovarian cancer in Taiwan: fine particulate matter (Pm2.5) as a proxy marker. J Toxicol Env Heal A. 2012;75(3):174–82.CrossRef
13.
Liaw YP, Ting TF, Ho KK, Yang CF. Cell type specificity of lung cancer associated with air pollution. Sci Total Environ. 2008;395(1):23–7.CrossRef
14.
Liu CC, Tsai SS, Chiu HF, Wu TN, Yang CY. Ambient exposure to criteria air pollutants and female lung cancer in Taiwan. Inhal Toxicol. 2008;20(3):311–7.CrossRef
15.
Tseng CY, Huang YC, Su SY, Huang JY, Lai CH, Lung CC, et al. Cell type specificity of female lung cancer associated with sulfur dioxide from air pollutants in Taiwan: an ecological study. BMC Public Health. 2012;12:4.CrossRef
16.
Hystad P, Villeneuve PJ, Goldberg MS, Crouse DL, Johnson K, Epidemiol CCR. Exposure to traffic-related air pollution and the risk of developing breast cancer among women in eight Canadian provinces: a case-control study. Environ Int. 2015;74:240–8.CrossRef
17.
Shekarrizfard M, Valois MF, Weichenthal S, Goldberg MS, Fallah-Shorshani M, Cavellin LD, et al. Investigating the effects of multiple exposure measures to traffic-related air pollution on the risk of breast and prostate cancer. J Transp Health. 2018;11:34–46.CrossRef
18.
Vieira VM, Villanueva C, Chang J, Ziogas A, Bristow RE. Impact of community disadvantage and air pollution burden on geographic disparities of ovarian cancer survival in California. Environ Res. 2017;156:388–93.CrossRef
19.
Cohen AJ, Brauer M, Burnett R, Anderson HR, Frostad J, Estep K, et al. Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the global burden of diseases study 2015. Lancet. 2017;389(10082):1907–18.CrossRef
20.
Loomis D, Huang W, Chen GS. The International Agency for Research on Cancer (IARC) evaluation of the carcinogenicity of outdoor air pollution: focus on China. Chin J Cancer. 2014;33(4):189–96.CrossRef
21.
Bayraktar H, Turalioglu FS. A kriging-based approach for locating a sampling site - in the assessment of air quality. Stoch Env Res Risk A. 2005;19(4):301–5.CrossRef
22.
Liu CY, Hung YT, Chuang YL, Chen YJ, Weng WS, Liu JS, et al. Incorporating development stratification of Taiwan townships into sampling Design of Large Scale Health Interview Survey. J Health Manag. 2006;4(1):1–22.
23.
Lu HY, Wu YL, Mutuku JK, Chang KH. Various sources of PM2.5 and their impact on the air quality in Tainan City, Taiwan. Aerosol Air Qual Res. 2019;19(3):601–19.CrossRef
24.
Hsu CY, Chiang HC, Chen MJ, Chuang CY, Tsen CM, Fang GC, et al. Ambient PM2.5 in the residential area near industrial complexes: spatiotemporal variation, source apportionment, and health impact. Sci Total Environ. 2017;590:204–14.CrossRef
25.
26.
27.
28.
Sorensen M, Autrup H, Moller P, Hertel O, Jensen SS, Vinzents P, et al. Linking exposure to environmental pollutants with biological effects. Mutat Res-Rev Mutat. 2003;544(2–3):255–71.CrossRef
29.
Gabelova A, Valovicova Z, Horvathova E, Slamenova D, Binkova B, Sram RJ, et al. Genotoxicity of environmental air pollution in three European cities: Prague, Kosice and Sofia. Mutat Res-Gen Tox En. 2004;563(1):49–59.CrossRef
30.
Danielsen PH, Risom L, Wallin H, Autrup H, Vogel U, Loft S, et al. DNA damage in rats after a single oral exposure to diesel exhaust particles. Mutat Res-Fund Mol M. 2008;637(1–2):49–55.CrossRef
31.
Valavanidis A, Fiotakis K, Vlachogianni T. Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms. J Environ Sci Heal C. 2008;26(4):339–62.CrossRef
32.
DeMarini DM. Genotoxicity biomarkers associated with exposure to traffic and near-road atmospheres: a review. Mutagenesis. 2013;28(5):485–505.CrossRef
33.
34.
35.
36.
Huang SK, Kuo L, Chou KL. The impacts of government policies on green utilization diffusion and social benefits - a case study of electric motorcycles in Taiwan. Energ Policy. 2018;119:473–86.CrossRef
37.
Mercer LD, Szpiro AA, Sheppard L, Lindstrom J, Adar SD, Allen RW, et al. Comparing universal kriging and land-use regression for predicting concentrations of gaseous oxides of nitrogen (NOx) for the multi-ethnic study of atherosclerosis and air pollution (MESA air). Atmos Environ. 2011;45(26):4412–20.CrossRef
Metadata
Title
Associations between ambient air pollution and cancer incidence in Taiwan: an ecological study of geographical variations
Authors
Shih-Yung Su
Yung-Po Liaw
Jing-Rong Jhuang
Shu-Yi Hsu
Chun-Ju Chiang
Ya-Wen Yang
Wen-Chung Lee
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Air Pollutants
Published in
BMC Public Health / Issue 1/2019
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-019-7849-z

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