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BMC Public Health
Published in: BMC Public Health 1/2019

Open Access 01-12-2019 | Helicobacter Pylori | Research article

Antibiotic dispensation rates among participants in community-driven health research projects in Arctic Canada

Authors: Kathleen Williams, Amy Colquhoun, Rachel Munday, Karen J. Goodman, CANHelp Working Group

Published in: BMC Public Health | Issue 1/2019

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Abstract

Background

Community-driven projects that aim to address public concerns about health risks from H. pylori infection in Indigenous Arctic communities (estimated H. pylori prevalence = 64%) show frequent failure of treatment to eliminate the bacterium. Among project participants, treatment effectiveness is reduced by antibiotic resistance of infecting H. pylori strains, which in turn, is associated with frequent exposure to antibiotics used to treat other infections. This analysis compares antibiotic dispensation rates in Canadian Arctic communities to rates in urban and rural populations in Alberta, a southern Canadian province.

Methods

Project staff collected antibiotic exposure histories for 297 participants enrolled during 2007–2012 in Aklavik, Tuktoyaktuk, and Fort McPherson in the Northwest Territories, and Old Crow, Yukon. Medical chart reviews collected data on systemic antibiotic dispensations for the 5-year period before enrolment for each participant. Antibiotic dispensation data for urban Edmonton, Alberta (average population ~ 860,000) and rural northern Alberta (average population ~ 450,000) during 2010–2013 were obtained from the Alberta Government Interactive Health Data Application.

Results

Antibiotic dispensation rates, estimated as dispensations/person-years (95% confidence interval) were: in Arctic communities, 0.89 (0.84, 0.94); in Edmonton, 0.55 (0.55, 0.56); in rural northern Alberta, 0.63 (0.62, 0.63). Antibiotic dispensation rates were higher in women and older age groups in all regions. In all regions, the highest dispensation rates occurred for β-lactam and macrolide antibiotic classes.

Conclusions

These results show more frequent antibiotic dispensation in Arctic communities relative to an urban and rural southern Canadian population.
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Metadata
Title
Antibiotic dispensation rates among participants in community-driven health research projects in Arctic Canada
Authors
Kathleen Williams
Amy Colquhoun
Rachel Munday
Karen J. Goodman
CANHelp Working Group
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2019
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-019-7193-3

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