Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Public Health
Published in: BMC Public Health 1/2018

Open Access 01-12-2018 | Research article

Epidemiology of birth defects based on surveillance data from 2011–2015 in Guangxi, China: comparison across five major ethnic groups

Authors: Jichang Chen, Xuemei Huang, Bo Wang, Yu Zhang, Chokechai Rongkavilit, Dingyuan Zeng, Yongjiang Jiang, Ba Wei, Chawla Sanjay, Eric McGrath

Published in: BMC Public Health | Issue 1/2018

Login to get access

Abstract

Background

The causes of birth defects (BDs) are complex and include genetic and environmental factors and/or their interactions. More research is needed to describe the epidemiology of BDs within specific regions of China. This study focused on differences in the prevalence of BDs based on ethnicity in a large city in Guangxi Province, China.

Methods

Surveillance data of infants born in 114 registered hospitals in Liuzhou between 2011 and 2015 were analyzed to determine the epidemiology of BDs across five major ethnic groups. We calculated the prevalence of BDs and relative risk of BDs by ethnicity.

Results

There were 260,722 perinatal infants of which 6581 had BDs, with the average prevalence of 25.24 per 1000 perinatal infants (PIs). Prevalence data showed an obvious uptrend over the past 5 years. Han had the highest prevalence of total BDs (28.98‰), followed by Zhuang (25.19‰), Yao (18.50‰), Miao (15.78‰) and Dong (14.24‰). Relative to the Han; Zhuang, Miao, Yao, and Dong had a lower risk of musculoskeletal and urogenital malformations; Miao and Yao had a lower risk of cardiovascular malformation; and Dong had a lower risk of cardiovascular and craniofacial malformation. Several maternal risk factors were found to be associated with BDs (e.g., maternal and gestational age, number of antenatal care visits).

Conclusion

This study provided a comprehensive description of ethnic differences in the risk of BDs in Liuzhou City, China. Observed ethnic differences in the risk of BDs may be related to genetic susceptibilities, environment, cultural customs, or to potential combinations of these factors.
Literature
1.
The global burden of disease: 2004 Update. In. Edited by organization WH. Geneva; 2008: 1–160.
2.
Castillo Taucher S. March or dimes global report on birth defects. Revista medica de Chile. 2007;135(6):806–13.PubMed
3.
China Birth Defects Prevention Report (2012). In. Beijing: The Ministry of Health issued; 2012: 1–24.[in Chinese].
4.
Li D, Guangxuan Z, Jun Z, Lei M, Yanping W, Yanqiao W, Juan L, Meng M: Impacts of birth defects on perinatal deaths in Chinese population. CHINESE JOURNAL OF EPIDEMIOLOGY 2004, 25(2):138–141.[in Chinese].
5.
Guixia C, Guozhang Z, Xiaozheng C, Lishan W: Meta analysis for surveillance of mortality among children under 5 years old in China from 2001 to 2010. Chinese Journal of Healthy Birth & Child Care 2013, 19(8):619–621.[in Chinese].
6.
Yuanyuan K, Yumin Z, Hui D: General Situation and Progress of Neonatal Disease Screening. Chinese Journal of Preventive Medicine 2011, 45(10):954–956.[in Chinese].
7.
Zhonghua Siyuangongcheng Fupin Jijinhui BTCJ, Beijing Shifan Daxue Zhongguogongyi Yanjiuyuan: Blue Book of Thalassemia in China. Beijing: Zhongguo Shehui Chubanshe; 2016.[in Chinese].
8.
Nelson K, Holmes LB. Malformations due to presumed spontaneous mutations in newborn infants. N Engl J Med. 1989;320(1):19–23.CrossRefPubMed
9.
Turnpenny P, Ellard S. Emery's elements of medical genetics. 12th ed. Edinburgh, United Kingdom: Elsevier Churchill Livingstone; 2004.
10.
Jun Z: The discussion on experience of managing national maternal and child health surveillance program. Zhonghua Yi Xue Ke Yan Guan Li Za Zhi 2002, 15(3):144–146.[in Chinese].
11.
Lowry RB, Thunem NY, Anderson-Redick S: Alberta Congenital Anomalies Surveillance System. CMAJ: Canadian Medical Association journal = journal de l'Association medicale canadienne 1989, 141(11):1155–1159.
12.
Annas GJ, Elias S. Thalidomide and the titanic: reconstructing the technology tragedies of the twentieth century. Am J Public Health. 1999;89(1):98–101.CrossRefPubMedPubMedCentral
13.
Edmonds LD, Layde PM, James LM, Flynt JW, Erickson JD, Oakley GP Jr. Congenital malformations surveillance: two American systems. Int J Epidemiol. 1981;10(3):247–52.CrossRefPubMed
14.
Misra T, Dattani N, Majeed A. Congenital anomaly surveillance in England and Wales. Public Health. 2006;120(3):256–64.CrossRefPubMed
15.
Xu XY, Yang JH, Ma XM, Liu AL, Liu K, He S, Mi HY, Li L: Neonatal complications and birth defects in infants conceived by in vitro fertilization. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 2015, 17(4):350–355.[in Chinese].
16.
Yang M, Zhang SQ, Du YK. Epidemiology characteristics of birth defects in Shenzhen city during 2003 to 2009, China. J Matern-Fetal Neo M. 2015;28(7–8):799–803.CrossRef
17.
Wu JL, Chen G, Song XM, Li CF, Zhang L, Liu L, Zheng XY. Spatiotemporal property analysis of birth defects in Wuxi, China. Biomed Environ Sci. 2008;21(5):432–7.CrossRefPubMed
18.
Li D, Jun Z, Juan L, Yan-ping W, He W, Meng M. Birth defects surveillance in China. World journal of pediatrics: WJP. 2011;7(4):302–10.CrossRef
19.
Jiapeng C, Lei Z, Gong C, Xinming S, Xiaoying Z: Capacity of monitoring system on birth defects during 1990s in China. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2006, 27(5):392–395.[in Chinese].
20.
Birth defects tracking and prevention; too many states are not making the grade. In.: Trust for America's Health; 2002: 1–20.
21.
Ju GABZAGL: Zhong Hua Ren Min Gong He Guo Quan Guo Fen Xian Shi Ren Kou Tong Ji Zi Liao(2012): Qunzhong Chubanshe; 2014.[in Chinese].
22.
Guomin Jingji Zongshu. In. Edited by Tongjiwang LX. Liuzhou 2012.[in Chinese].
23.
Guangxi Zhuangzu Zizhiqu Tongjiju GZZRB: Guangxi Zhuangzu Zizhiqu2010nian Renkoupucha Ziliao. In.; 2012.[in Chinese].
24.
Zhengfu GZZR: Fengtu Renqing. In. Guangxi Nanning: Guangxi Zhuangzu Zizhiqu Renmin Zhengfu; 2016.[in Chinese].
25.
Xie D, Yang T, Liu Z, Wang H: Epidemiology of birth defects based on a birth defect surveillance system from 2005 to 2014 in Hunan Province, China. PLoS One. 2016, 11(1):1–8.
26.
Zeng E: Analysis of birth defects of perinatal children in Guangxi Zhuang Autonomous Region from 2001 to 2010. Chinese Journal of Primary Medicine and Pharmacy 2012, 19(18):2743–2745.[in Chinese].
27.
Fang W, Xue G, Gong C, Xinming S, Liangming L, Xiaoying Z: Comparison of epidemiological features of birth defects between population-based and hospital-based surveys in high-prevalence areas of China. Chin J Evid Based Pediatr. 2012, 7(4):252–258.[in Chinese].
28.
Bin L, Xiaozhuang Z, Nin Y, Li M, Jianhong X, Xiujian H, Shaolan H: Guangdongshen 1997-2007nian Yiyuan Jiance Chusheng Quexian Qushi Fenxi. Zhonghua Liuxingbingxue Zazhi 2008, 29(11):1101–1105.[in Chinese].
29.
Zhang X, Li S, Wu S, Hao X, Guo S, Kota S, Yokomichi H. Prevalence of birth defects and risk-factor analysis from a population-based survey in Inner Mongolia, China. BMC pediatrics. 2012;12:125.CrossRefPubMedPubMedCentral
30.
Egbe AC. Birth defects in the newborn population: race and ethnicity. Pediatrics and neonatology. 2015;56(3):183–8.CrossRefPubMed
31.
Lamichhane DK, Leem JH, Park M, Kim JA, Kim HC, Kim JH, Hong YC. Increased prevalence of some birth defects in Korea, 2009-2010. BMC pregnancy and childbirth. 2016;16:61.CrossRefPubMedPubMedCentral
32.
Hoang T, Nguyen DT, Nguyen PV, Tran DA, Gillerot Y, Reding R, Robert A. External birth defects in southern Vietnam: a population-based study at the grassroots level of health care in Binh Thuan Province. BMC Pediatr. 2013;13:67.CrossRefPubMedPubMedCentral
33.
Cassell CH, Golden L. Epidemiology as a guardian of children's health: translating birth defects research into policy. Ann Epidemiol. 2010;20(7):493–8.CrossRefPubMed
34.
Collins JS, Kirby RS: Birth defects surveillance, epidemiology, and significance in public health. Birth defects research Part A, Clinical and molecular teratology 2009, 85(11):873.
35.
Kirby RS, Browne ML. Birth defects surveillance: epidemiology, health services research, public health, and prevention. Birth defects research Part A, Clinical and molecular teratology. 2013;97(10):617–8.CrossRefPubMed
36.
Aggarwal D, Warmerdam B, Wyatt K, Ahmad S, Shaw GM. Prevalence of birth defects among american-indian births in California, 1983-2010. Birth Defects Research (Part A). 2015;103:105–10.CrossRef
37.
Ruo-yun Q, Hong L, Nan Z, Rui W, Hong-yun Z, Jiang H, Wu-zhong Y. Xinjiang Duominzu Diqu Chusheng Quexian Fenxi. Zhongguo Zuzhi Gongcheng Yanjiu Yu Linchuang Kangfu. 2011;15(20):3797–800.
38.
Xunqiang Y, Hongzhuang T, Wenjie G, Qi-yun D, Zhiyi L: Yunchanfu Fenmian NianlilngYu Juzhudi Dui Chusheng Quexian De Yingxiang. Zhongguo Xiandai Yixue Zazhi 2012, 22(7):90–92.[in Chinese].
39.
Alborz A. Environmental characteristics and prevalence of birth defects among children in post-war Iraq: implications for policies on rebuilding the Iraqi education system. Med Confl Surviv. 2013;29(1):26–44.CrossRefPubMed
40.
Yuli C, Wei W, Ping Z, Jianmei L, Yue-hua H, Yali L, Yu Z: Baoanqu 2006-2010nian Weichaner Xiantianxing Xinzangbing Jiance Jieguo Fenxi. Zhongguo Fuyou Baojian 2011, 26(36):5780–5782.[in Chinese].
Metadata
Title
Epidemiology of birth defects based on surveillance data from 2011–2015 in Guangxi, China: comparison across five major ethnic groups
Authors
Jichang Chen
Xuemei Huang
Bo Wang
Yu Zhang
Chokechai Rongkavilit
Dingyuan Zeng
Yongjiang Jiang
Ba Wei
Chawla Sanjay
Eric McGrath
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2018
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-018-5947-y

Other articles of this Issue 1/2018

BMC Public Health 1/2018 Go to the issue

Research article

Physical inactivity, gender and culture in Arab countries: a systematic assessment of the literature

Research article

Attendance barriers experienced by female health care workers voluntarily participating in a multi-component health promotion programme at the workplace

Research article

National trends and characteristics of inpatient detoxification for drug use disorders in the United States

Research article

Impact of financial burden, resulting from prescription co-payments, on antihypertensive medication adherence in an older publically insured population

Research article

The incidence of acute myeloid leukemia in Calgary, Alberta, Canada: a retrospective cohort study

Research article

Smoking among immigrant groups in metropolitan France: prevalence levels, male-to-female ratios and educational gradients