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Published in: BMC Public Health 1/2018

Open Access 01-12-2018 | Study protocol

Interrupting seasonal transmission of Schistosoma haematobium and control of soil-transmitted helminthiasis in northern and central Côte d’Ivoire: a SCORE study protocol

Authors: Yves-Nathan T. Tian-Bi, Mamadou Ouattara, Stefanie Knopp, Jean T. Coulibaly, Eveline Hürlimann, Bonnie Webster, Fiona Allan, David Rollinson, Aboulaye Meïté, Nana R. Diakité, Cyrille K. Konan, Eliézer K. N’Goran, Jürg Utzinger

Published in: BMC Public Health | Issue 1/2018

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Abstract

Background

To achieve a world free of schistosomiasis, the objective is to scale up control and elimination efforts in all endemic countries. Where interruption of transmission is considered feasible, countries are encouraged to implement a comprehensive intervention package, including preventive chemotherapy, information, education and communication (IEC), water, sanitation and hygiene (WASH), and snail control. In northern and central Côte d’Ivoire, transmission of Schistosoma haematobium is seasonal and elimination might be achieved. In a cluster-randomised trial, we will assess different treatment schemes to interrupt S. haematobium transmission and control soil-transmitted helminthiasis over a 3-year period. We will compare the impact of (i) arm A: annual mass drug administration (MDA) with praziquantel and albendazole before the peak schistosomiasis transmission season; (ii) arm B: annual MDA after the peak schistosomiasis transmission season; (iii) arm C: two yearly treatments before and after peak schistosomiasis transmission; and (iv) arm D: annual MDA before peak schistosomiasis transmission, coupled with chemical snail control using niclosamide.

Methods/design

The prevalence and intensity of S. haematobium and soil-transmitted helminth infections will be assessed using urine filtration and Kato-Katz thick smears, respectively, in six administrative regions in northern and central parts of Côte d’Ivoire. Once a year, urine and stool samples will be collected and examined from 50 children aged 5–8 years, 100 children aged 9–12 years and 50 adults aged 20–55 years in each of 60 selected villages. Changes in S. haematobium and soil-transmitted helminth prevalence and intensity will be assessed between years and stratified by intervention arm. In the 15 villages randomly assigned to intervention arm D, intermediate host snails will be collected three times per year, before niclosamide is applied to the selected freshwater bodies. The snail abundance and infection rates over time will allow drawing inference on the force of transmission.

Discussion

This cluster-randomised intervention trial will elucidate whether in an area with seasonal transmission, the four different treatment schemes can interrupt S. haematobium transmission and control soil-transmitted helminthiasis. Lessons learned will help to guide schistosomiasis control and elimination programmes elsewhere in Africa.

Trial registration

ISRCTN ISRCTN10926858. Registered 21 December 2016. Retrospectively registered.
Literature
1.
de Silva NR, Brooker S, Hotez PJ, Montresor A, Engels D, Savioli L. Soil-transmitted helminth infections: updating the global picture. Trends Parasitol. 2003;19:547–51.CrossRefPubMed
2.
3.
Montresor A, Crompton DWT, Gyorkos TW, Savioli L. Helminth control in school-age children: a guide for managers of control programmes. Geneva: World Health Organization; 2002.
4.
Herricks JR, Hotez PJ, Wanga V, Coffeng LE, Haagsma JA, Basáñez MG, et al. The Global Burden of Disease study 2013: what does it mean for the NTDs? PLoS Negl Trop Dis. 2017;11:e0005424.
5.
6.
Montresor A. Lutte contre les helminthiases chez les enfants d'âge scolaire: guide à l'intention des responsables des programmes de lutte. Geneva: World Health Organization; 2004.
7.
Stephenson LS, Latham MC, Ottesen EA. Malnutrition and parasitic helminth infections. Parasitology. 2000;121(Suppl 1):23–8.CrossRef
8.
Hotez PJ, Brooker S, Bethony JM, Bottazzi ME, Loukas A, Xiao SH. Current concepts: hookworm infection. N Engl J Med. 2004;351:799–807.CrossRefPubMed
9.
WHO. Prevention and control of schistosomiasis and soil-transmitted helminthiasis: report of a WHO expert committee. WHO Tech Rep Ser 2002;912:1–57.
10.
Doumenge J-P, Mott KE, Cheung C, Villenave D, Chapuis C, Perrin MF, et al. Atlas of the global distribution of schistosomiasis. Centre d’Etudes de Géographie Tropicale (C.N.R.S.)/World Health Organization. Talence: Presse Universitaires de Bordeaux; 1987.
11.
N’Goran EK. Biodiversité, transmission et épidémiologie de Schistosoma haematobium, Bilharz, 1852 et des schistosomes apparentés en Côte d’Ivoire. Perpignan: Thèse Doct; 1997.
12.
Cecchi P. L’eau en partage: les petits barrages de Côte d’Ivoire. IRD Editions; 2013.
13.
Hürlimann E, Schur N, Boutsika K, Stensgaard AS, Laizer N, Laserna de Himpsl M, et al. Toward an open-access global database for mapping, control, and surveillance of neglected tropical diseases. PLoS Negl Trop Dis. 2011;5:e1404.CrossRefPubMedPubMedCentral
14.
Schur N, Hürlimann E, Garba A, Traoré MS, Ndir O, Ratard RC, et al. Geostatistical model-based estimates of schistosomiasis prevalence among individuals aged ≤20 years in West Africa. PLoS Negl Trop Dis. 2015;5:e1194.
15.
Yapi RB, Hürlimann E, Houngbedji CA, N’Dri PB, Silué KD, Soro G, et al. Infection and co-infection of helminths and Plasmodium among school children in Côte d’Ivoire: results from a national cross-sectional survey. PLoS Negl Trop Dis. 2014;8:e2913.CrossRefPubMedPubMedCentral
16.
Krauth SJ, Greter H, Stete K, Coulibaly JT, Traoré SI, Ngandolo BN, Achi LY, Zinsstag J, N’Goran EK, Utzinger J. All that is blood is not schistosomiasis: experiences with reagent strip testing for urogenital schistosomiasis with special consideration to very-low prevalence settings. Parasit Vectors. 2015;8:584.CrossRefPubMedPubMedCentral
17.
18.
19.
20.
Rollinson D, Knopp S, Levitz S, Stothard JR, Tchuem Tchuenté LA, Garba A, et al. Time to set the agenda for schistosomiasis elimination. Acta Trop. 2013;128:423–40.CrossRefPubMed
21.
Swartz SJ, De Leo GA, Wood CL, Sokolow SH. Infection with schistosome parasites in snails leads to increased predation by prawns: implications for human schistosomiasis control. J Exp Biol. 2015;218:3962–7.CrossRefPubMed
22.
WHO. Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers. Geneva: World Health Organization; 2006.
23.
Tchuem Tchuenté LA, N’Goran EK. Schistosomiasis and soil-transmitted helminthiasis control in Cameroon and Côte d’Ivoire: implementing control on a limited budget. Parasitology. 2009;136:1739–45.CrossRef
24.
Bonfoh B, Raso G, Koné I, Dao D, Girardin O, Cissé G, Zinsstag J, Utzinger J, Tanner M. Research in a war zone. Nature. 2011;474:569–71.CrossRefPubMed
25.
Assaré RK, Knopp S, N’Guessan NA, Yapi A, Tian-Bi YNT, Yao PK, et al. Sustaining control of schistosomiasis mansoni in moderate endemicity areas in western Côte d’Ivoire: a SCORE study protocol. BMC Public Health. 2014;14:1290.CrossRefPubMedPubMedCentral
26.
Assaré RK, Tian-Bi YNT, Yao PK, N’Guessan NA, Ouattara M, Yapi A, et al. Sustaining control of schistosomiasis mansoni in western Côte d’Ivoire: results from a SCORE study, one year after initial praziquantel administration. PLoS Negl Trop Dis. 2016;10:e0004329.CrossRefPubMedPubMedCentral
27.
Assaré RK, Hürlimann E, Ouattara M, N’Guessan NA, Tian-Bi YNT, Yapi A, et al. Sustaining the control of Schistosoma mansoni in western Côte d'Ivoire: baseline findings before the implementation of a randomized trial. Am J Trop Med Hyg. 2016;94:352–60.CrossRefPubMedPubMedCentral
28.
Coulibaly JT, N’Gbesso YK, N’Guessan NA, Winkler MS, Utzinger J, N’Goran EK. Epidemiology of schistosomiasis in two high-risk communities of south Côte d'Ivoire with particular emphasis on pre-school–aged children. Am J Trop Med Hyg. 2013;89:32–41.CrossRefPubMedPubMedCentral
29.
WHO. Schistosomiasis: progress report 2001–2011 and strategic plan 2012-2020. Geneva: World Health Organization; 2013.
30.
WHO. Accelerating work to overcome the global impact of neglected tropical diseases – a roadmap for implementation; executive summary. Geneva: World Health Organization; 2012.
31.
Peel MC, Finlayson BL, McMahon TA. Updated world map of the Köppen–Geiger climate classification. Hydrol Earth Syst Sci. 2007;11:1633–44.CrossRef
32.
INS. Recensement général de la population et de l’habitat: Résultats globaux. Institut National de la Statistique, Secrétariat Technique Permanent du Comité Technique du RGPH; 2014.
33.
N’Goran EK, Utzinger J, Traoré M, Lengeler C, Tanner M. Identification rapide par questionnaire des principaux foyers de bilharziose urinaire au centre de la Côte d’Ivoire. Med Trop. 1998;58:253–60.
34.
Plouvier S, Leroy JC, Colette JA. Simple method for urine filtration in the diagnosis of urinary schistosomiasis in large-scale surveys. Med Trop. 1975;35:229–30.
35.
Gleeson MJ, Connolly J, Grainger R, McDermott TED, Butler MR. Comparison of reagent strip (dipstick) and microscopic haematuria in urological out-patients. Br J Urol. 1993;72:594–6.CrossRefPubMed
36.
Coulibaly JT, Knopp S, N’Guessan NA, Silué KD, Fürst T, Lohourignon LK, et al. Accuracy of urine circulating cathodic antigen (CCA) test for Schistosoma mansoni diagnosis in different settings of Côte d'Ivoire. PLoS Negl Trop Dis. 2011;5:e1384.
37.
Knopp S, Person B, Ame SM, Mohammed KA, Ali SM, Khamis IS, et al. Elimination of schistosomiasis transmission in Zanzibar: baseline findings before the onset of a randomized intervention trial. PLoS Negl Trop Dis. 2013;7:e2474.CrossRefPubMedPubMedCentral
38.
Peters PA, Mahmoud AA, Warren KS, Ouma JH, Siongok TA. Field studies of a rapid, accurate means of quantifying Schistosoma haematobium eggs in urine samples. Bull World Health Organ. 1976;54:159.
39.
Katz N, Chaves A, Pellegrino JA. Simple device for quantitative stool thick smear technique in schistosomiasis mansoni. Rev Inst Med Trop São Paulo. 1972;14:397–400.PubMed
40.
Montresor A, Ramsan M, Chwaya HM, Ameir H, Foum A, Albonico M, et al. School enrollment in Zanzibar linked to children’s age and helminth infections. Trop Med Int Health. 2001;6:227–31.CrossRefPubMed
41.
WHO. WHO specifications and evaluations for public health pesticides. Niclosamide 2′, 5-dichloro-4′-nitrosalicylanilide. Geneva: World Health Organization; 2002.
42.
Yang GJ, Li W, Sun LP, Wu F, Yang K, Huang YX, et al. Molluscicidal efficacies of different formulations of niclosamide: result of meta-analysis of Chinese literature. Parasit Vectors. 2010;3:84.CrossRefPubMedPubMedCentral
43.
44.
Belkacemi M, Jana M. Curage et traitement molluscicide pour la lutte contre la schistosomiase. East Mediterr Health J. 2006;12:129.PubMed
45.
Salem S, Mitchell RE, El-Alim el-Dorey A, Smith JA, Barocas DA. Successful control of schistosomiasis and the changing epidemiology of bladder cancer in Egypt. BJU Int. 2011;107:206–11.
46.
Knopp S, Mohammed KA, Ali SM, Khamis IS, Ame SM, Albonico M, et al. Study and implementation of urogenital schistosomiasis elimination in Zanzibar (Unguja and Pemba islands) using an integrated multidisciplinary approach. BMC Public Health. 2012;12:930.CrossRefPubMedPubMedCentral
47.
Frandsen F, Christensen NO. Introductory guide to the identification of cercariae from African freshwater snails with special reference to cercariae of trematode species of medical and veterinary importance. Acta Trop. 1984;41:181–202.PubMed
48.
49.
Montresor A, Engels D, Chitsulo L, Bundy DAP, Brooker S, Savioli L. Development and validation of a 'tablet pole' for the administration of praziquantel in sub-Saharan Africa. Trans R Soc Trop Med Hyg. 2001;95:542–4.CrossRefPubMedPubMedCentral
50.
N’Goran EK, Utzinger J, N’Guessan AN, Müller I, Zamblé K, Lohourignon KL, et al. Reinfection with Schistosoma haematobium following school-based chemotherapy with praziquantel in four highly endemic villages in Côte d’Ivoire. Trop Med Int Health. 2001;6:817–25.
51.
Koné S, Baikoro N, N’Guessan Y, Jaeger FN, Silué KD, Fürst T, et al. Health and demographic surveillance system profile: the Taabo health and demographic surveillance system, Côte d’Ivoire. Int J Epidemiol. 2014;44:87–97.CrossRefPubMed
52.
Kahama AI, Vennervald BJ, Kombe Y, Kihara RW, Ndzovu M, Mungai P, et al. Parameters associated with Schistosoma haematobium infection before and after chemotherapy in school children from two villages in the Coast province of Kenya. Trop Med Int Health. 1999;4:335–40.
53.
Saathoff E, Olsen A, Magnussen P, Kvalsvig JD, Becker W, Appleton CC. Patterns of Schistosoma haematobium infection, impact of praziquantel treatment and re-infection after treatment in a cohort of schoolchildren from rural KwaZulu-Natal/South Africa. BMC Infect Dis. 2004;4:40.CrossRefPubMedPubMedCentral
54.
Satayathum SA, Muchiri EM, Ouma JH, Whalen CC, King CH. Factors affecting infection or reinfection with Schistosoma haematobium in coastal Kenya: survival analysis during a nine-year, school-based treatment program. Am J Trop Med Hyg. 2006;75:83–92.PubMedPubMedCentral
55.
Gray DJ, McManus DP, Li Y, Williams GM, Bergquist R, Ross AG. Schistosomiasis elimination: lessons from the past guide the future. Lancet Infect Dis. 2010;10:733–6.CrossRefPubMed
56.
57.
Sarquis O, Pieri OS, Santos JAAD. Effects of Bayluscide WP 70® on the survival and water-leaving behaviour of Biomphalaria straminea, snail host of schistosomiasis in northeast Brazil. Mem Inst Oswaldo Cruz. 1997;92:619–23.CrossRefPubMed
58.
Dai JR, Li YZ, Wang W, Xing YT, GL Q, Liang YS. Resistance to niclosamide in Oncomelania hupensis, the intermediate host of Schistosoma japonicum: should we be worried. Parasitology. 2015;142:332–40.CrossRefPubMed
Metadata
Title
Interrupting seasonal transmission of Schistosoma haematobium and control of soil-transmitted helminthiasis in northern and central Côte d’Ivoire: a SCORE study protocol
Authors
Yves-Nathan T. Tian-Bi
Mamadou Ouattara
Stefanie Knopp
Jean T. Coulibaly
Eveline Hürlimann
Bonnie Webster
Fiona Allan
David Rollinson
Aboulaye Meïté
Nana R. Diakité
Cyrille K. Konan
Eliézer K. N’Goran
Jürg Utzinger
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2018
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-018-5044-2

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