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BMC Public Health
Published in: BMC Public Health 1/2017

Open Access 01-12-2017 | Research article

The singular epidemiology of HPV infection among French Guianese women with normal cytology

Authors: Antoine Adenis, Valentin Dufit, Maylis Douine, Fatiha Najioullah, Vincent Molinie, Dominique Catherine, Odile Kilié, Nadia Thomas, Jean Luc Deshayes, Paul Brousse, Hatem Ben Amor, Remy Pignoux, Gabriel Carles, Claire Grenier, Vincent Lacoste, Raymond Cesaire, Mathieu Nacher

Published in: BMC Public Health | Issue 1/2017

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Abstract

Background

In French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana.

Methods

Before the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear. Only women with normal cytology and a good quality smear were analyzed. The detection of HPV-DNA was performed using the GREINER-BIO-ONE kit.

Results

Overall, 27.2% of women with normal cervical cytology had a positive HPV-test. There was a U-shaped evolution of prevalence with women over 50 years having the highest HPV prevalence, followed by the 20 to 29 years group. The most prevalent HPV genotypes were HPV 53(3.52%), 68(3.33%), 52(2.59%), 31(2.22%) and 16 (1.85%). The proportion of HPV 16 among HPV-infected women was 6.8%.

Conclusions

HPV prevalence in cytologically normal women was very high. The most prevalent genotypes were very different from what is usually described in the world, and notably in South America.
Literature
1.
Roue T, Nacher M, Fior A, Plenet J, Belliardo S, et al. Cervical cancer incidence in French Guiana: South American. Int J Gynecol Cancer. 2012;22:850–3.CrossRefPubMed
2.
Douine M, Roue T, Fior A, Adenis A, Thomas N, et al. Survival of patients with invasive cervical cancer in French Guiana, 2003-2008. Int J Gynaecol Obstet. 2014;125:166–7.CrossRefPubMed
3.
Arrossi S, Sankaranarayanan R, Parkin DM. Incidence and mortality of cervical cancer in Latin America. Salud Publica Mex. 2003;45(Suppl 3):S306–14.PubMed
4.
van Melle A, Parriault MC, Basurko C, Jolivet A, Flamand C, et al. Knowledge, attitudes, behaviors, and practices differences regarding HIV in populations living along the Maroni river: particularities of operational interest for Amerindian and Maroon populations. AIDS Care. 2015;27:1112–7.CrossRefPubMed
5.
Ayhan G, Martin L, Levy-Loeb M, Thomas S, Euzet G, et al. Prevalence and risk factors of early onset of sexual intercourse in a random sample of a multiethnic adolescent population in French Guiana. AIDS Care. 2015;27:1025–30.CrossRefPubMed
6.
(ANSM) ANdSdMedPdS. Mise sur le marché du vaccin pour la prévention d’infections liées au virus papilloma; 2007.
7.
8.
de Roda Husman AM, Walboomers JM, Hopman E, Bleker OP, Helmerhorst TM, et al. HPV prevalence in cytomorphologically normal cervical scrapes of pregnant women as determined by PCR: the age-related pattern. J Med Virol. 1995;46:97–102.CrossRefPubMed
9.
Hildesheim A, Schiffman MH, Gravitt PE, Glass AG, Greer CE, et al. Persistence of type-specific human papillomavirus infection among cytologically normal women. J Infect Dis. 1994;169:235–40.CrossRefPubMed
10.
Kjaer SK, van den Brule AJ, Bock JE, Poll PA, Engholm G, et al. Determinants for genital human papillomavirus (HPV) infection in 1000 randomly chosen young Danish women with normal Pap smear: are there different risk profiles for oncogenic and nononcogenic HPV types? Cancer Epidemiol Biomark Prev. 1997;6:799–805.
11.
Melkert PW, Hopman E, van den Brule AJ, Risse EK, van Diest PJ, et al. Prevalence of HPV in cytomorphologically normal cervical smears, as determined by the polymerase chain reaction, is age-dependent. Int J Cancer. 1993;53:919–23.CrossRefPubMed
12.
Wheeler CM, Parmenter CA, Hunt WC, Becker TM, Greer CE, et al. Determinants of genital human papillomavirus infection among cytologically normal women attending the University of New Mexico student health center. Sex Transm Dis. 1993;20:286–9.CrossRefPubMed
13.
Clifford GM, Gallus S, Herrero R, Munoz N, Snijders PJ, et al. Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis. Lancet. 2005;366:991–8.CrossRefPubMed
14.
de Sanjose S, Diaz M, Castellsague X, Clifford G, Bruni L, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis. 2007;7:453–9.CrossRefPubMed
15.
Matos E, Loria D, Amestoy GM, Herrera L, Prince MA, et al. Prevalence of human papillomavirus infection among women in Concordia, Argentina: a population-based study. Sex Transm Dis. 2003;30:593–9.CrossRefPubMed
16.
Ferreccio C, Prado RB, Luzoro AV, Ampuero SL, Snijders PJ, et al. Population-based prevalence and age distribution of human papillomavirus among women in Santiago, Chile. Cancer Epidemiol Biomark Prev. 2004;13:2271–6.
17.
Molano M, Posso H, Weiderpass E, van den Brule AJ, Ronderos M, et al. Prevalence and determinants of HPV infection among Colombian women with normal cytology. Br J Cancer. 2002;87:324–33.CrossRefPubMedPubMedCentral
18.
Fonseca AJ, Taeko D, Chaves TA, Amorim LD, Murari RS, Miranda AE, Chen Z, Burk RD, Ferreira LC, et al. HPV Infection and Cervical Screening in Socially Isolated Indigenous Women Inhabitants of the Amazonian Rainforest. PLoS One. 2015;10(7):e0133635. doi:10.​1371/​journal.​pone.​0133635. eCollection 2015.
19.
Lazcano-Ponce E, Herrero R, Munoz N, Cruz A, Shah KV, et al. Epidemiology of HPV infection among Mexican women with normal cervical cytology. Int J Cancer. 2001;91:412–20.CrossRefPubMed
20.
Herrero RC, Castle PE, Schiffman M, et al. Epidemiologic profile of type-specific HPV infection and cervical neoplasia in Guanacaste, Costa Rica. J Infect Dis. 2005;191:1796–807.CrossRefPubMed
21.
Richardson HKG, Tellier P, et al. The natural history of type-specific human papillomavirus infections in female university students. Cancer Epidemiol Biomark Prev. 2003;12:485–90.
22.
Brown DRL, Legge D, Qadadri B. Distribution of human papillomavirus types in cervicovaginal washings from women evaluated in a sexually transmitted diseases clinic. Sex Transm Dis. 2002;29:763–8.CrossRefPubMed
23.
Fernandez-Vina MA, Gao XJ, Moraes ME, Moraes JR, Salatiel I, et al. Alleles at four HLA class II loci determined by oligonucleotide hybridization and their associations in five ethnic groups. Immunogenetics. 1991;34:299–312.CrossRefPubMed
24.
Allen M, Kalantari M, Ylitalo N, Pettersson B, Hagmar B, et al. HLA DQ-DR haplotype and susceptibility to cervical carcinoma: indications of increased risk for development of cervical carcinoma in individuals infected with HPV 18. Tissue Antigens. 1996;48:32–7.CrossRefPubMed
25.
Mahmud SM, Robinson K, Richardson H, Tellier PP, Ferenczy AS, et al. HLA polymorphisms and cervical human Papillomavirus infection in a cohort of Montreal University students. J Infect Dis. 2007;196:82–90.CrossRefPubMed
26.
Maciag PC, Schlecht NF, Souza PS, Franco EL, Villa LL, et al. Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women. Cancer Epidemiol Biomark Prev. 2000;9:1183–91.
27.
Metcalfe S, Roger M, Faucher MC, Coutlee F, Franco EL, et al. The association between human leukocyte antigen (HLA)-G polymorphisms and human papillomavirus (HPV) infection in Inuit women of northern Quebec. Hum Immunol. 2013;74:1610–5.CrossRefPubMed
28.
Sankaranarayanan R, Nene BM, Shastri SS, Jayant K, Muwonge R, et al. HPV screening for cervical cancer in rural India. N Engl J Med. 2009;360:1385–94.CrossRefPubMed
Metadata
Title
The singular epidemiology of HPV infection among French Guianese women with normal cytology
Authors
Antoine Adenis
Valentin Dufit
Maylis Douine
Fatiha Najioullah
Vincent Molinie
Dominique Catherine
Odile Kilié
Nadia Thomas
Jean Luc Deshayes
Paul Brousse
Hatem Ben Amor
Remy Pignoux
Gabriel Carles
Claire Grenier
Vincent Lacoste
Raymond Cesaire
Mathieu Nacher
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2017
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-017-4181-3

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