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BMC Public Health
Published in: BMC Public Health 1/2017

Open Access 01-12-2017 | Research Article

Mathematical analysis of a lymphatic filariasis model with quarantine and treatment

Authors: Peter M. Mwamtobe, Simphiwe M. Simelane, Shirley Abelman, Jean M. Tchuenche

Published in: BMC Public Health | Issue 1/2017

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Abstract

Background

Lymphatic filariasis is a globally neglected tropical parasitic disease which affects individuals of all ages and leads to an altered lymphatic system and abnormal enlargement of body parts.

Methods

A mathematical model of lymphatic filariaris with intervention strategies is developed and analyzed. Control of infections is analyzed within the model through medical treatment of infected-acute individuals and quarantine of infected-chronic individuals.

Results

We derive the effective reproduction number, \(\mathcal {R}_{0},\) and its interpretation/investigation suggests that treatment contributes to a reduction in lymphatic filariasis cases faster than quarantine. However, this reduction is greater when the two intervention approaches are applied concurrently.

Conclusions

Numerical simulations are carried out to monitor the dynamics of the filariasis model sub-populations for various parameter values of the associated reproduction threshold. Lastly, sensitivity analysis on key parameters that drive the disease dynamics is performed in order to identify their relative importance on the disease transmission.
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Metadata
Title
Mathematical analysis of a lymphatic filariasis model with quarantine and treatment
Authors
Peter M. Mwamtobe
Simphiwe M. Simelane
Shirley Abelman
Jean M. Tchuenche
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2017
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-017-4160-8

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