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Published in: BMC Public Health 1/2016

Open Access 01-12-2016 | Research article

Implementation challenges and opportunities for HIV Treatment as Prevention (TasP) among young men in Vancouver, Canada: a qualitative study

Authors: Rod Knight, Will Small, Kim Thomson, Mark Gilbert, Jean Shoveller

Published in: BMC Public Health | Issue 1/2016

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Abstract

Background

Despite evidence supporting the preventative potential of HIV Treatment as Prevention (TasP), scientific experts and community stakeholders have suggested that the success of TasP at the population level will require overcoming a set of complex and population-specific implementation challenges. For example, the factors that might influence decisions to initiate ‘early’ treatment have yet to be thoroughly understood; neither have questions about the factors that enhance or impede their ability to achieve long-term adherence to ARVs or the social norms regarding various treatment regimens been examined in detail. This knowledge gap may hamper opportunities to effectively develop public health practices that are informed by the various challenges and opportunities related to TasP implementation and scale up.

Methods

Drawing on 50 in-depth, individual interviews with young men ages 18–24 in Vancouver, Canada, this study examines young men’s perspectives regarding factors that might affect their engagement with TasP.

Results

While findings from the current study indicate young men generally have a high receptiveness to TasP, our findings also identify key social and structural forces that will warrant ongoing consideration for TasP implementation. For example, participants described how an enhanced awareness regarding treatment (including awareness of the universal availability of treatment in Vancouver) would be a necessary, but not sufficient, condition to decide to endorse TasP. Their decisions about engaging in HIV care in the context of TasP (e.g., HIV testing, treatment initiation, long-term adherence) also appear to be contingent on their ability to negotiate or ‘balance’ the risks and benefits to themselves and others. The findings also offer insight into the complex and sometimes controversial narratives that continue to emerge regarding risk compensation practices in the context of TasP.

Conclusion

Based on the results of this study, we identify several areas that hold promise for informing the effective scale up of TasP, including new information regarding implementation adaptation strategies.
Literature
1.
go back to reference Chang LW, Serwadda D, Quinn TC, Wawer MJ. Combination implementation for HIV prevention: moving from clinical trial evidence to population-level effects. Lancet Infect Dis. 2013;13(1):65–76.CrossRefPubMedPubMedCentral Chang LW, Serwadda D, Quinn TC, Wawer MJ. Combination implementation for HIV prevention: moving from clinical trial evidence to population-level effects. Lancet Infect Dis. 2013;13(1):65–76.CrossRefPubMedPubMedCentral
2.
go back to reference Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet. 2009;373(9657):48–57.CrossRefPubMed Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet. 2009;373(9657):48–57.CrossRefPubMed
3.
go back to reference Montaner J, Lima VD, Barrios R, Yip B, Wood E. Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study. Lancet. 2010;376(9740):523–39.CrossRef Montaner J, Lima VD, Barrios R, Yip B, Wood E. Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study. Lancet. 2010;376(9740):523–39.CrossRef
4.
go back to reference Tanser F, Barnighausen T, Grapsa E, Zaidi J, Newell ML. High coverage of ART Associated with decline in risk of HIV acquisition in rural KwaZulu-Natal, South Africa. Science. 2013;339(6122):966–71.CrossRefPubMedPubMedCentral Tanser F, Barnighausen T, Grapsa E, Zaidi J, Newell ML. High coverage of ART Associated with decline in risk of HIV acquisition in rural KwaZulu-Natal, South Africa. Science. 2013;339(6122):966–71.CrossRefPubMedPubMedCentral
6.
go back to reference UNAIDS. 90-90-90-An ambitious treatment target to help end the AIDS epidemic. 2014. p. 32. UNAIDS. 90-90-90-An ambitious treatment target to help end the AIDS epidemic. 2014. p. 32.
7.
go back to reference Rodger A, Bruun T, Weait M, et al. HIV transmission risk through condomless sex if HIV+ partner on suppressive ART: PARTNER study. Boston: Proceedings of the 21st Conference on Retroviruses and Opportunistic Infections; 2014. Rodger A, Bruun T, Weait M, et al. HIV transmission risk through condomless sex if HIV+ partner on suppressive ART: PARTNER study. Boston: Proceedings of the 21st Conference on Retroviruses and Opportunistic Infections; 2014.
8.
go back to reference Montaner JS, Hogg R, Wood E, et al. The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic. Lancet. 2006;368(9534):531–6.CrossRefPubMed Montaner JS, Hogg R, Wood E, et al. The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic. Lancet. 2006;368(9534):531–6.CrossRefPubMed
9.
11.
go back to reference British Columbia Centre for Disease Control. 2012 HIV annual report. 2012. p. 43. British Columbia Centre for Disease Control. 2012 HIV annual report. 2012. p. 43.
12.
go back to reference British Columbia Provincial Health Officer. 2014 Annual Report - HIV, Stigma and Society: tackling a complex epidemic and renewing HIV prevention for gay and bisexual Men in British Columbia. 2014. p. 104. British Columbia Provincial Health Officer. 2014 Annual Report - HIV, Stigma and Society: tackling a complex epidemic and renewing HIV prevention for gay and bisexual Men in British Columbia. 2014. p. 104.
13.
go back to reference Knight RE, Shoveller JA, Oliffe JL, et al. Heteronormativity hurts everyone: Young men’s and clinician’s experiences with STI testing. Health. 2013;17(5):441–59.CrossRefPubMed Knight RE, Shoveller JA, Oliffe JL, et al. Heteronormativity hurts everyone: Young men’s and clinician’s experiences with STI testing. Health. 2013;17(5):441–59.CrossRefPubMed
14.
go back to reference Shoveller JA, Knight RE, Oliffe J, et al. ‘Not the swab!’ Young men’s experiences with STI testing. Sociol Health Illn. 2010;32(1):57–73.CrossRefPubMed Shoveller JA, Knight RE, Oliffe J, et al. ‘Not the swab!’ Young men’s experiences with STI testing. Sociol Health Illn. 2010;32(1):57–73.CrossRefPubMed
15.
go back to reference Schwarz S, Richards TA, Frank H, et al. Identifying barriers to HIV testing: personal and contextual factors associated with late HIV testing. AIDS Care. 2010;23(7):892–900.CrossRef Schwarz S, Richards TA, Frank H, et al. Identifying barriers to HIV testing: personal and contextual factors associated with late HIV testing. AIDS Care. 2010;23(7):892–900.CrossRef
16.
go back to reference Adam PCG, de Wit John BF, Bourne CP, et al. Promoting Regular Testing: an examination of HIV and STI Testing Routines and Associated socio-demographic, behavioral and social-cognitive factors among men who have sex with men in New South Wales, Australia. AIDS Behav. 2014;18(5):921–32.CrossRefPubMed Adam PCG, de Wit John BF, Bourne CP, et al. Promoting Regular Testing: an examination of HIV and STI Testing Routines and Associated socio-demographic, behavioral and social-cognitive factors among men who have sex with men in New South Wales, Australia. AIDS Behav. 2014;18(5):921–32.CrossRefPubMed
17.
go back to reference Balfe M, Brugha R, O'Connell E, et al. Men’s attitudes towards chlamydia screening: a narrative review. Sex Health. 2011;9(2):120–30. Balfe M, Brugha R, O'Connell E, et al. Men’s attitudes towards chlamydia screening: a narrative review. Sex Health. 2011;9(2):120–30.
18.
go back to reference Evans J, Frank B, Oliffe JL, Gregory D. Health, Illness, Men and Masculinities (HIMM): a theoretical framework for understanding men and their health. J Mens Health. 2011;8(1):7–15.CrossRef Evans J, Frank B, Oliffe JL, Gregory D. Health, Illness, Men and Masculinities (HIMM): a theoretical framework for understanding men and their health. J Mens Health. 2011;8(1):7–15.CrossRef
19.
go back to reference Creighton G, Oliffe JL. Theorising masculinities and men’s health: A brief history with a view to practice. Health Sociol Rev. 2010;19(4):409–18.CrossRef Creighton G, Oliffe JL. Theorising masculinities and men’s health: A brief history with a view to practice. Health Sociol Rev. 2010;19(4):409–18.CrossRef
20.
go back to reference Vogel DL, Heimerdinger-Edwards SR, Hammer JH, Hubbard A. “Boys don't cry”: Examination of the links between endorsement of masculine norms, self-stigma, and help-seeking attitudes for men from diverse backgrounds. J Couns Psychol. 2011;58(3):368–82.CrossRefPubMed Vogel DL, Heimerdinger-Edwards SR, Hammer JH, Hubbard A. “Boys don't cry”: Examination of the links between endorsement of masculine norms, self-stigma, and help-seeking attitudes for men from diverse backgrounds. J Couns Psychol. 2011;58(3):368–82.CrossRefPubMed
21.
go back to reference Connell RW. Gender, health and theory: conceptualizing the issue, in local and world perspective. Soc Sci Med. 2012;74(11):1675–83.CrossRefPubMed Connell RW. Gender, health and theory: conceptualizing the issue, in local and world perspective. Soc Sci Med. 2012;74(11):1675–83.CrossRefPubMed
22.
go back to reference Knight R, Shoveller JA, Oliffe JL, et al. Masculinities, ‘guy talk’ and ‘manning up’: a discourse analysis of how young men talk about sexual health. Sociol Health Illn. 2012;34:1246–61.CrossRefPubMed Knight R, Shoveller JA, Oliffe JL, et al. Masculinities, ‘guy talk’ and ‘manning up’: a discourse analysis of how young men talk about sexual health. Sociol Health Illn. 2012;34:1246–61.CrossRefPubMed
23.
go back to reference Knight R, Shoveller JA, Oliffe JL, et al. Heteronormativity hurts everyone: Experiences of young men and clinicians with sexually transmitted infection/HIV testing in British Columbia, Canada. Health. 2013;17(5):441–59.CrossRefPubMed Knight R, Shoveller JA, Oliffe JL, et al. Heteronormativity hurts everyone: Experiences of young men and clinicians with sexually transmitted infection/HIV testing in British Columbia, Canada. Health. 2013;17(5):441–59.CrossRefPubMed
24.
go back to reference Oliffe JL, Chabot C, Knight R, et al. Women on men’s sexual health and sexually transmitted infection testing: a gender relations analysis. Sociol Health Illn. 2012;35(1):1–16.CrossRefPubMed Oliffe JL, Chabot C, Knight R, et al. Women on men’s sexual health and sexually transmitted infection testing: a gender relations analysis. Sociol Health Illn. 2012;35(1):1–16.CrossRefPubMed
25.
go back to reference Robertson S. Understanding Men and Health: Masculinities, Identity and Well-Being. New York: Open University Press; 2007. Robertson S. Understanding Men and Health: Masculinities, Identity and Well-Being. New York: Open University Press; 2007.
26.
go back to reference Courtenay WH. Constructions of masculinity and their influence on men’s well-being: a theory of gender and health. Soc Sci Med. 2000;50(10):1385–401.CrossRefPubMed Courtenay WH. Constructions of masculinity and their influence on men’s well-being: a theory of gender and health. Soc Sci Med. 2000;50(10):1385–401.CrossRefPubMed
27.
go back to reference Katz IT, Ryu AE, Onuegbu AG, Psaros C, Weiser SD, Bangsberg DR, Tsai AC. Impact of HIV-related stigma on treatment adherence: systematic review and meta-synthesis. J Int AIDS Soc. 2013;16(Suppl2):18640.PubMedPubMedCentral Katz IT, Ryu AE, Onuegbu AG, Psaros C, Weiser SD, Bangsberg DR, Tsai AC. Impact of HIV-related stigma on treatment adherence: systematic review and meta-synthesis. J Int AIDS Soc. 2013;16(Suppl2):18640.PubMedPubMedCentral
28.
go back to reference Young I, McDaid L. How acceptable are antiretrovirals for the prevention of sexually transmitted HIV?: A review of research on the acceptability of oral pre-exposure prophylaxis and treatment as prevention. AIDS Behav. 2014;18(2):195–216.CrossRefPubMed Young I, McDaid L. How acceptable are antiretrovirals for the prevention of sexually transmitted HIV?: A review of research on the acceptability of oral pre-exposure prophylaxis and treatment as prevention. AIDS Behav. 2014;18(2):195–216.CrossRefPubMed
29.
go back to reference Dombrowski JC, Harrington RD, Fleming M, Golden MR. Letter to the Editor: Treatment as prevention: are HIV clinic patients interested in starting antiretroviral therapy to decrease HIV transmission? AIDS Patient Care STDs. 2010;24(12):747–50.CrossRefPubMedPubMedCentral Dombrowski JC, Harrington RD, Fleming M, Golden MR. Letter to the Editor: Treatment as prevention: are HIV clinic patients interested in starting antiretroviral therapy to decrease HIV transmission? AIDS Patient Care STDs. 2010;24(12):747–50.CrossRefPubMedPubMedCentral
30.
go back to reference Kalichman SC, Eaton L, Cherry C. Sexually transmitted infections and infectiousness beliefs among people living with HIV/AIDS: implications for HIV treatment as prevention. HIV Med. 2010;11(8):502–9.PubMedPubMedCentral Kalichman SC, Eaton L, Cherry C. Sexually transmitted infections and infectiousness beliefs among people living with HIV/AIDS: implications for HIV treatment as prevention. HIV Med. 2010;11(8):502–9.PubMedPubMedCentral
31.
go back to reference Holt M, Murphy D, Callander D, et al. HIV-negative and HIV-positive gay men’s attitudes to medicines, HIV treatments and antiretroviral-based prevention. AIDS Behav. 2012;17(6):2156–61.CrossRef Holt M, Murphy D, Callander D, et al. HIV-negative and HIV-positive gay men’s attitudes to medicines, HIV treatments and antiretroviral-based prevention. AIDS Behav. 2012;17(6):2156–61.CrossRef
32.
go back to reference Archer M, Bhaskar R, Collier A, Lawson T, Norrie A. Chapter 22: Introduction. In: Critical realism: essential readings. New York: Routledge; 2013. p. 3–15. Archer M, Bhaskar R, Collier A, Lawson T, Norrie A. Chapter 22: Introduction. In: Critical realism: essential readings. New York: Routledge; 2013. p. 3–15.
33.
go back to reference Clark AM. What are the components of complex interventions in healthcare? Theorizing approaches to parts, powers and the whole intervention. Soc Sci Med. 2013;93(C):185–93.CrossRefPubMed Clark AM. What are the components of complex interventions in healthcare? Theorizing approaches to parts, powers and the whole intervention. Soc Sci Med. 2013;93(C):185–93.CrossRefPubMed
34.
go back to reference Wood E, Stoltz JA, Montaner JSG, Kerr T. Evaluating methamphetamine use and risks of injection initiation among street youth: The ARYS study. Harm Reduct J. 2006;3(18):1–6. Wood E, Stoltz JA, Montaner JSG, Kerr T. Evaluating methamphetamine use and risks of injection initiation among street youth: The ARYS study. Harm Reduct J. 2006;3(18):1–6.
35.
go back to reference Fereday J, Muir-Cochrane E. Demonstrating rigor using thematic analysis: A hybrid approach of inductive and deductive coding and theme development. Int J Qual Methods. 2008;5(1):80–92. Fereday J, Muir-Cochrane E. Demonstrating rigor using thematic analysis: A hybrid approach of inductive and deductive coding and theme development. Int J Qual Methods. 2008;5(1):80–92.
36.
go back to reference International Association of Physicians in AIDS Care. Consensus Statement - Controlling the HIV pandemic with antiretrovirals: treatment as prevention and pre-exposure prophylaxis. 2012. p. 20. International Association of Physicians in AIDS Care. Consensus Statement - Controlling the HIV pandemic with antiretrovirals: treatment as prevention and pre-exposure prophylaxis. 2012. p. 20.
37.
go back to reference Chan R. Biomedical strategies for human immunodeficiency virus (HIV) prevention? A new paradigm. Ann Acad Med Singapore. 2012;41:595–601.PubMed Chan R. Biomedical strategies for human immunodeficiency virus (HIV) prevention? A new paradigm. Ann Acad Med Singapore. 2012;41:595–601.PubMed
38.
go back to reference Knight R, Small W, Pakula B, Thomson K. A scoping study to identify opportunities to advance the ethical implementation and scale-up of HIV treatment as prevention: priorities for empirical research. BMC Med Ethics. 2014;15:54.CrossRefPubMedPubMedCentral Knight R, Small W, Pakula B, Thomson K. A scoping study to identify opportunities to advance the ethical implementation and scale-up of HIV treatment as prevention: priorities for empirical research. BMC Med Ethics. 2014;15:54.CrossRefPubMedPubMedCentral
40.
go back to reference Haire B, Kaldor JM. Ethics of ARV based prevention: treatment-as-prevention and PrEP. Dev World Bioeth. 2013;13:63–9.CrossRefPubMed Haire B, Kaldor JM. Ethics of ARV based prevention: treatment-as-prevention and PrEP. Dev World Bioeth. 2013;13:63–9.CrossRefPubMed
41.
go back to reference Grinsztejn B, Hosseinipour MC, Ribaudo HJ, et al. Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial. Lancet. 2014;14:281–90.CrossRefPubMedPubMedCentral Grinsztejn B, Hosseinipour MC, Ribaudo HJ, et al. Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial. Lancet. 2014;14:281–90.CrossRefPubMedPubMedCentral
Metadata
Title
Implementation challenges and opportunities for HIV Treatment as Prevention (TasP) among young men in Vancouver, Canada: a qualitative study
Authors
Rod Knight
Will Small
Kim Thomson
Mark Gilbert
Jean Shoveller
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2016
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-016-2943-y

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