Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Public Health
Published in: BMC Public Health 1/2015

Open Access 01-12-2015 | Research article

Comparison of IgG against plastic resin in workers with and without chemical dermatitis

Authors: Toshihiro Kawamoto, Mayumi Tsuji, Toyohi Isse

Published in: BMC Public Health | Issue 1/2015

Login to get access

Abstract

Background

There are many chemical sensitizers which cause allergy in the surrounding environment. However, the identification of substances causing allergy is difficult. We developed a new method to detect IgG which reacts against many kinds of chemical-human serum albumin (HSA) adducts at the same time. In this study, the diagnostic significance of the IgG was studied among workers of a company where a mass outbreak of chemical dermatitis had occurred after changing a plastic resin to a new one.

Methods

Eleven workers who handled the new plastic resin and suffered from dermatitis (case) and 9 workers who also handled the same resin in the same company but were free from dermatitis (control) were the subjects. Immunological dot blotting was carried out to detect serum IgG using originally prepared diagnostic antigens, comprising a mixture of HSA and the plastic resin or its components under various conditions.

Results

IgG against the plastic resin in use was detected in all workers who suffered from dermatitis. The prevalence of the IgG against the plastic resin was significantly higher in workers with than in those without dermatitis. On the other hand, IgG against its components (bisphenol A diglycidyl ether, m-xylylenediamine and butyl 2,3-epoxypropyl ether) was detected in a few workers with dermatitis.

Discussion

This suggests that IgG against chemical-HSA adduct reflects not only exposure but also causative chemicals of dermatitis. Our method to use a material itself as a hapten is practical and useful in the occupational field.

Conclusion

It is suggested that IgG against chemicals is a useful marker of chemicals inducing dermatitis.
Appendix
Available only for authorised users
Literature
1.
Prodi A, Rui F, Fortina AB, Corradin MT, Filon FL. Occupational sensitization to epoxy resins in Northeastern Italy (1996–2010). Int J Occup Environ Health. 2015;21(1):82–7.CrossRefPubMedPubMedCentral
2.
3.
Bangsgaard N, Thyssen JP, Menne T, Andersen KE, Mortz CG, Paulsen E, et al. Contact allergy to epoxy resin: risk occupations and consequences. Contact Dermatitis. 2012;67(2):73–7.CrossRefPubMed
4.
Murakami T, Oyama T, Isse T, Ogawa M, Sugie T, Kawamoto T. International comparison of criteria for evaluating sensitization of PRTR-designated chemical substances. Environ Health Prev Med. 2007;12(2):56–65.CrossRefPubMedPubMedCentral
5.
Murakami T, Oyma T, Isse T, Narai R, Kanaoka M, Pham TT, et al. International comparison of sensitizing chemical substances. J UOEH. 2007;29(3):303–88.PubMed
6.
Hillen U, Frosch PJ, John SM, Pirker C, Wundenberg J, Goos M. Patch test sensitization caused by para-tertiary-butylcatechol. Results of a prospective study with a dilution series. Contact Dermatitis. 2001;45(4):193–6.CrossRefPubMed
7.
Miller SP, Marinkovich VA, Riege DH, Sell WJ, Baker DL, Eldredge NT, et al. Application of the MAST Immunodiagnostic System to the determination of allergen-specific IgE. Clin Chem. 1984;30(9):1467–72.PubMed
8.
Vojdani A, Ghoneum M, Brautbar N. Immune alteration associated with exposure to toxic chemicals. Toxicol Ind Health. 1992;8(5):239–54.PubMed
9.
Pronk A, Preller L, Raulf-Heimsoth M, Jonkers IC, Lammers JW, Wouters IM, et al. Respiratory symptoms, sensitization, and exposure response relationships in spray painters exposed to isocyanates. Am J Respir Crit Care Med. 2007;176(11):1090–7.CrossRefPubMedPubMedCentral
10.
Wisnewski AV, Stowe MH, Nerlinger A, Opare-Addo P, Decamp D, Kleinsmith CR, et al. Biomonitoring Hexamethylene diisocyanate (HDI) exposure based on serum levels of HDI-specific IgG. Ann Occup Hyg. 2012;56(8):901–10.CrossRefPubMedPubMedCentral
11.
Kawamoto T, Nitta H, Murata K, Toda E, Tsukamoto N, Hasegawa M, et al. Rationale and study design of the Japan environment and children's study (JECS). BMC Public Health. 2014;14:25.CrossRefPubMedPubMedCentral
12.
Konno S, Takahashi D, Hizawa N, Hattori T, Takahashi A, Isada A, et al. Genetic impact of a butyrophilin-like 2 (BTNL2) gene variation on specific IgE responsiveness to Dermatophagoides farinae (Der f) in Japanese. Allergol Int. 2009;58(1):29–35.CrossRefPubMed
Metadata
Title
Comparison of IgG against plastic resin in workers with and without chemical dermatitis
Authors
Toshihiro Kawamoto
Mayumi Tsuji
Toyohi Isse
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2015
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-015-2302-4

Other articles of this Issue 1/2015

BMC Public Health 1/2015 Go to the issue

Research article

Variation in the effects of family background and birth region on adult obesity: results of a prospective cohort study of a Great Depression-era American cohort

Research article

Demographic and socio-economic factors associated with multiple health risk behaviours among adolescents in Serbia: a cross sectional study

Research article

Validity of a two-item physical activity questionnaire for assessing attainment of physical activity guidelines in youth

Research article

Finding the keys to successful adult-targeted advertisements on obesity prevention: an experimental audience testing study

Research article

Intra-household evaluations of alcohol abuse in men with depression and suicide in women: A cross-sectional community-based study in Chennai, India

Research article

Vaccination decision-making of immigrant parents in the Netherlands; a focus group study