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Published in: BMC Public Health 1/2015

Open Access 01-12-2015 | Research article

Reducing diarrhoea deaths in South Africa: costs and effects of scaling up essential interventions to prevent and treat diarrhoea in under-five children

Authors: Lumbwe Chola, Julia Michalow, Aviva Tugendhaft, Karen Hofman

Published in: BMC Public Health | Issue 1/2015

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Abstract

Background

Diarrhoea is one of the leading causes of morbidity and mortality in South African children, accounting for approximately 20% of under-five deaths. Though progress has been made in scaling up multiple interventions to reduce diarrhoea in the last decade, challenges still remain. In this paper, we model the cost and impact of scaling up 13 interventions to prevent and treat childhood diarrhoea in South Africa.

Methods

Modelling was done using the Lives Saved Tool (LiST). Using 2014 as the baseline, intervention coverage was increased from 2015 until 2030. Three scale up scenarios were compared: by 2030, 1) coverage of all interventions increased by ten percentage points; 2) intervention coverage increased by 20 percentage points; 3) and intervention coverage increased to 99%.

Results

The model estimates 13 million diarrhoea cases at baseline. Scaling up intervention coverage averted between 3 million and 5.3 million diarrhoea cases. In 2030, diarrhoeal deaths are expected to reduce from an estimated 5,500 in 2014 to 2,800 in scenario one, 1,400 in scenario two and 100 in scenario three. The additional cost of implementing all 13 interventions will range from US$510 million (US$9 per capita) to US$960 million (US$18 per capita), of which the health system costs range between US$40 million (less than US$1 per capita) and US$170 million (US$3 per capita).

Conclusion

Scaling up 13 essential interventions could have a substantial impact on reducing diarrhoeal deaths in South African children, which would contribute toward reducing child mortality in the post-MDG era. Preventive measures are key and the government should focus on improving water, sanitation and hygiene. The investments required to achieve these results seem feasible considering current health expenditure.
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Literature
1.
go back to reference Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379(9832):2151–61.CrossRefPubMed Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379(9832):2151–61.CrossRefPubMed
2.
go back to reference Statistics South Africa: Levels and trends of morbidity and mortality among children aged under-five years in South Africa, 2006–2010. Pretoria, South Africa: Statistics South Africa; 2012. Statistics South Africa: Levels and trends of morbidity and mortality among children aged under-five years in South Africa, 2006–2010. Pretoria, South Africa: Statistics South Africa; 2012.
3.
go back to reference Dorrington RE, Bradshaw D, Laubscher R. Rapid mortality surveillance report 2012. Cape Town, South Africa: South African Medical Research Council; 2014. Dorrington RE, Bradshaw D, Laubscher R. Rapid mortality surveillance report 2012. Cape Town, South Africa: South African Medical Research Council; 2014.
4.
go back to reference UNICEF: Pneumonia and diarrhoea: tackling the deadliest diseases for the world’s poorest children. UNICEF; 2012 UNICEF: Pneumonia and diarrhoea: tackling the deadliest diseases for the world’s poorest children. UNICEF; 2012
5.
go back to reference Tindyebwa D, Kayita J, Musoke P, Eley B, Nduati R, Coovadia H, et al. Handbook on paediatric AIDS in Africa by the African Network for the Care of Children Affected by AIDS: USAID; 2006. Tindyebwa D, Kayita J, Musoke P, Eley B, Nduati R, Coovadia H, et al. Handbook on paediatric AIDS in Africa by the African Network for the Care of Children Affected by AIDS: USAID; 2006.
6.
go back to reference Bamford L. Maternal, Newborn and Child Health. In: Padarath A, English R, editors. South African Health Review. Durban: Health Systems Trust; 2013. Bamford L. Maternal, Newborn and Child Health. In: Padarath A, English R, editors. South African Health Review. Durban: Health Systems Trust; 2013.
7.
go back to reference UNICEF, WHO: Diarrhoea: Why children are still dying and what can be done? WHO Bulletin; 2009 UNICEF, WHO: Diarrhoea: Why children are still dying and what can be done? WHO Bulletin; 2009
8.
go back to reference Madhi SA, Cunliffe NA, Steele D, Witte D, Kirsten M, Louw C, et al. Effect of Human Rotavirus Vaccine on Severe Diarrhea in African Infants. N Engl J Med. 2010;362(4):289–98.CrossRefPubMed Madhi SA, Cunliffe NA, Steele D, Witte D, Kirsten M, Louw C, et al. Effect of Human Rotavirus Vaccine on Severe Diarrhea in African Infants. N Engl J Med. 2010;362(4):289–98.CrossRefPubMed
9.
go back to reference UNICEF, WHO. Immunisation summary: A statistical reference containing data through 2013. WHO; 2014 UNICEF, WHO. Immunisation summary: A statistical reference containing data through 2013. WHO; 2014
10.
go back to reference Statistics South Africa: Water and sanitation 2002–2010: in-depth analysis of the General Household Survey data. Statistics South Africa; 2011 Statistics South Africa: Water and sanitation 2002–2010: in-depth analysis of the General Household Survey data. Statistics South Africa; 2011
11.
go back to reference South African Human Rights Commission: Report on the right to access sufficient water and decent sanitation in South Africa. South African Human Rights Commission; 2014 South African Human Rights Commission: Report on the right to access sufficient water and decent sanitation in South Africa. South African Human Rights Commission; 2014
12.
go back to reference Stover J, McKinnon R, Winfrey B. Spectrum: a model platform for linking maternal and child survival interventions with AIDS, family planning and demographic projections. Int J Epidemiol. 2010;39 Suppl 1:i7–10.CrossRefPubMedPubMedCentral Stover J, McKinnon R, Winfrey B. Spectrum: a model platform for linking maternal and child survival interventions with AIDS, family planning and demographic projections. Int J Epidemiol. 2010;39 Suppl 1:i7–10.CrossRefPubMedPubMedCentral
16.
go back to reference Cairncross S, Hunt C, Boisson S, Bostoen K, Curtis V, Fung IC, et al. Water, sanitation and hygiene for the prevention of diarrhoea. Int J Epidemiol. 2010;39 Suppl 1:i193–205.CrossRefPubMedPubMedCentral Cairncross S, Hunt C, Boisson S, Bostoen K, Curtis V, Fung IC, et al. Water, sanitation and hygiene for the prevention of diarrhoea. Int J Epidemiol. 2010;39 Suppl 1:i193–205.CrossRefPubMedPubMedCentral
17.
go back to reference Walker CL, Black RE. Zinc for the treatment of diarrhoea: effect on diarrhoea morbidity, mortality and incidence of future episodes. Int J Epidemiol. 2010;39 Suppl 1:i63–69.CrossRefPubMedPubMedCentral Walker CL, Black RE. Zinc for the treatment of diarrhoea: effect on diarrhoea morbidity, mortality and incidence of future episodes. Int J Epidemiol. 2010;39 Suppl 1:i63–69.CrossRefPubMedPubMedCentral
18.
go back to reference Munos MK, Walker CL, Black RE. The effect of oral rehydration solution and recommended home fluids on diarrhoea mortality. Int J Epidemiol. 2010;39 Suppl 1:i75–87.CrossRefPubMedPubMedCentral Munos MK, Walker CL, Black RE. The effect of oral rehydration solution and recommended home fluids on diarrhoea mortality. Int J Epidemiol. 2010;39 Suppl 1:i75–87.CrossRefPubMedPubMedCentral
21.
go back to reference Fischer Walker CL, Friberg IK, Binkin N, Young M, Walker N, Fontaine O, et al. Scaling up diarrhea prevention and treatment interventions: a Lives Saved Tool analysis. PLoS Med. 2011;8(3), e1000428.CrossRefPubMed Fischer Walker CL, Friberg IK, Binkin N, Young M, Walker N, Fontaine O, et al. Scaling up diarrhea prevention and treatment interventions: a Lives Saved Tool analysis. PLoS Med. 2011;8(3), e1000428.CrossRefPubMed
22.
go back to reference Bhutta ZA, Das JK, Walker N, Rizvi A, Campbell H, Rudan I, et al. Interventions to address deaths from childhood pneumonia and diarrhoea equitably: what works and at what cost? The Lancet. 2013;381(9875):1417–29.CrossRef Bhutta ZA, Das JK, Walker N, Rizvi A, Campbell H, Rudan I, et al. Interventions to address deaths from childhood pneumonia and diarrhoea equitably: what works and at what cost? The Lancet. 2013;381(9875):1417–29.CrossRef
23.
go back to reference UNICEF. Every Child Counts: The State of the World's Children. UNICEF; 2014 UNICEF. Every Child Counts: The State of the World's Children. UNICEF; 2014
24.
go back to reference UNICEF, WHO: Joint Monitoring Programme for Water Supply and Sanitation. Progress on drinking water and sanitation 2014. UNICEF, WHO: Joint Monitoring Programme for Water Supply and Sanitation. Progress on drinking water and sanitation 2014.
26.
go back to reference Management Sciences for Health, Word Health Organization: International drug price indicator guide. Frye JE (Eds). Cambridge, MA: WHO; 2012 Management Sciences for Health, Word Health Organization: International drug price indicator guide. Frye JE (Eds). Cambridge, MA: WHO; 2012
28.
go back to reference Department of Water Affairs and Forestry: Guideline for the costing of household sanitation projects: DWAF; 2007. Department of Water Affairs and Forestry: Guideline for the costing of household sanitation projects: DWAF; 2007.
29.
go back to reference City of Johannesburg: Amendment of tariff of charges for water services, Annexure 21: City of Johannesburg; 2012. City of Johannesburg: Amendment of tariff of charges for water services, Annexure 21: City of Johannesburg; 2012.
30.
go back to reference Bhutta ZA, Das JK, Bahl R, Lawn JE, Salam RA, Paul VK, et al. Can available interventions end preventable deaths in mothers, newborn babies, and stillbirths, and at what cost? The Lancet. 2014;384(9940):347–70.CrossRef Bhutta ZA, Das JK, Bahl R, Lawn JE, Salam RA, Paul VK, et al. Can available interventions end preventable deaths in mothers, newborn babies, and stillbirths, and at what cost? The Lancet. 2014;384(9940):347–70.CrossRef
31.
go back to reference Stenberg K, Axelson H, Sheehan P, Anderson I, Gülmezoglu AM, Temmerman M, et al. Advancing social and economic development by investing in women's and children's health: a new Global Investment Framework. Lancet. 2014;383(9925):1333–54.CrossRefPubMed Stenberg K, Axelson H, Sheehan P, Anderson I, Gülmezoglu AM, Temmerman M, et al. Advancing social and economic development by investing in women's and children's health: a new Global Investment Framework. Lancet. 2014;383(9925):1333–54.CrossRefPubMed
32.
go back to reference Statistics South Africa: Mid-year population estimates 2014. Statistics South Africa; 2014. Statistics South Africa: Mid-year population estimates 2014. Statistics South Africa; 2014.
34.
go back to reference Friend-du Preez N, Cameron N, Griffiths P. The importance of medicines in health-seeking behaviour for childhood illnesses in urban South Africa. Soc Sci Med. 2013;92:43–52.CrossRefPubMed Friend-du Preez N, Cameron N, Griffiths P. The importance of medicines in health-seeking behaviour for childhood illnesses in urban South Africa. Soc Sci Med. 2013;92:43–52.CrossRefPubMed
35.
go back to reference Venter F: HIV Treatment in South Africa: The challenges of an increasingly successful antiretroviral programme. South African Health Review 2012/13 2013 Venter F: HIV Treatment in South Africa: The challenges of an increasingly successful antiretroviral programme. South African Health Review 2012/13 2013
36.
go back to reference Chidiebere OD, Stanley O, Joy E, Clement E, Ifeyinwa N, Uchenna E: Effect of Exclusive Breastfeeding on Incidences of Illness in Infant’s First 6 Months of Life. Journal of Pediatrics and Neonatal Care 2014, 1(4): 00025. doi: 10.15406/jpnc.2014.01.00025. Chidiebere OD, Stanley O, Joy E, Clement E, Ifeyinwa N, Uchenna E: Effect of Exclusive Breastfeeding on Incidences of Illness in Infant’s First 6 Months of Life. Journal of Pediatrics and Neonatal Care 2014, 1(4): 00025. doi: 10.15406/jpnc.2014.01.00025.
37.
go back to reference Tylleskar T, Jackson D, Meda N, Engebretsen IM, Chopra M, Diallo AH, et al. Exclusive breastfeeding promotion by peer counsellors in sub-Saharan Africa (PROMISE-EBF): a cluster-randomised trial. Lancet. 2011;378(9789):420–7.CrossRefPubMed Tylleskar T, Jackson D, Meda N, Engebretsen IM, Chopra M, Diallo AH, et al. Exclusive breastfeeding promotion by peer counsellors in sub-Saharan Africa (PROMISE-EBF): a cluster-randomised trial. Lancet. 2011;378(9789):420–7.CrossRefPubMed
38.
go back to reference Bland RM, Little KE, Coovadia HM, Coutsoudis A, Rollins NC, Newell ML. Intervention to promote exclusive breast-feeding for the first 6 months of life in a high HIV prevalence area. AIDS (London, England). 2008;22(7):883–91.CrossRef Bland RM, Little KE, Coovadia HM, Coutsoudis A, Rollins NC, Newell ML. Intervention to promote exclusive breast-feeding for the first 6 months of life in a high HIV prevalence area. AIDS (London, England). 2008;22(7):883–91.CrossRef
40.
go back to reference Goosen C, MCLachlan M, Schubl C. Factors impeding exclusive breastfeeding in a low-income area of the Western Province of South Africa. Africa Journal of Nursing and Midwifery. 2011;16(1):13–31. Goosen C, MCLachlan M, Schubl C. Factors impeding exclusive breastfeeding in a low-income area of the Western Province of South Africa. Africa Journal of Nursing and Midwifery. 2011;16(1):13–31.
41.
go back to reference Mawela MP, de Villiers FP. The effect of admission on oral rehydration-related knowledge. Ann Trop Paediatr. 1999;19(1):75–81.CrossRefPubMed Mawela MP, de Villiers FP. The effect of admission on oral rehydration-related knowledge. Ann Trop Paediatr. 1999;19(1):75–81.CrossRefPubMed
42.
go back to reference Massyn N DC, Peer N, Padarath A, Barron P, English R, : District Health Barometer 2013/14. Health Systems Trust 2014 Massyn N DC, Peer N, Padarath A, Barron P, English R, : District Health Barometer 2013/14. Health Systems Trust 2014
44.
go back to reference Shisana O, Simbayi L, Rehle T, Zungu N, Suma K, Ngogo N, et al. South African National HIV Prevalence, Incidence, Behaviour and Communication Survey, 2008: The Health of our Children. Cape Town: HSRC Press; 2010. Shisana O, Simbayi L, Rehle T, Zungu N, Suma K, Ngogo N, et al. South African National HIV Prevalence, Incidence, Behaviour and Communication Survey, 2008: The Health of our Children. Cape Town: HSRC Press; 2010.
45.
go back to reference Guerrant RL, Kosek M, Moore S, Lorntz B, Brantley R, Lima AAM. Magnitude and Impact of Diarrheal Diseases. Arch Med Res. 2002;33(4):351–5.CrossRefPubMed Guerrant RL, Kosek M, Moore S, Lorntz B, Brantley R, Lima AAM. Magnitude and Impact of Diarrheal Diseases. Arch Med Res. 2002;33(4):351–5.CrossRefPubMed
46.
go back to reference Kramer M, Kakuma R. The optimal duration of exclusive breastfeeding. Cochrane Database of Systematic Reviews 2002, Issue 1. Art. No.: CD003517. DOI: 10.1002/14651858.CD003517 Kramer M, Kakuma R. The optimal duration of exclusive breastfeeding. Cochrane Database of Systematic Reviews 2002, Issue 1. Art. No.: CD003517. DOI: 10.1002/14651858.CD003517
47.
go back to reference Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, Sachs JD, et al. Control of neglected tropical diseases. N Engl J Med. 2007;357(10):1018–27.CrossRefPubMed Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, Sachs JD, et al. Control of neglected tropical diseases. N Engl J Med. 2007;357(10):1018–27.CrossRefPubMed
Metadata
Title
Reducing diarrhoea deaths in South Africa: costs and effects of scaling up essential interventions to prevent and treat diarrhoea in under-five children
Authors
Lumbwe Chola
Julia Michalow
Aviva Tugendhaft
Karen Hofman
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2015
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-015-1689-2

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