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Open Access 01-12-2021 | Obsessive-Compulsive Disorder | Research article

Correlational research on facial and clinical characteristics of adolescents with obsessive-compulsive disorder

Authors: Yan-Rong Wang, Shao-hua Chang, Xiao-Min Ma, Ji-Ying Li, Rui-Xia Zhang, Jian-Qun Fang

Published in: BMC Psychiatry | Issue 1/2021

Abstract

Background

The neurodevelopmental model of obsessive-compulsive disorder (OCD) suggests that the neurodevelopmental changes in the ventral striatal circuit of the prefrontal lobe are associated with the initial symptoms of OCD. Facial morphology is one of the most consistent anatomical phenotypes of neurodevelopmental disorders, which can reflect brain structure and function. Facial deformity, an easily measured index of brain malformation, can reflect abnormal brain structure and function. Therefore, this study aims to explore the relationship between clinical features and neurodevelopment of adolescents with OCD through facial morphology.

Methods

The enrolled study sample comprised 40 adolescents diagnosed with OCD using the Obsessive Compulsive Inventory-Child Version (OCI-CV) and 38 healthy controls (HCs). Facial photos, 21 facial diameters, and 9 facial angles were collected using image software.

Results

In males, lower lip red height was significantly lower in OCD patients than in HCs (P < 0.025); no significant differences were observed in other facial indicators (all P > 0.025). In females, the nasolabial angle was smaller in OCD patients than in HCs (P < 0.025); no significant differences were observed in other facial indicators (all P > 0.025). The difference in lower lip red height between the OCD group and HC group was positively correlated with neutralizing symptoms (r = 0.401, P < 0.05).

Conclusions

Male OCD patients had a thinner lower lip and female OCD patients had smaller nasolabial angles. The facial features of adolescents with OCD were positively correlated with lower lip redness and neutralizing symptoms.

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Title: Correlational research on facial and clinical characteristics of adolescents with obsessive-compulsive disorder
Authors: Yan-Rong Wang
Shao-hua Chang
Xiao-Min Ma
Ji-Ying Li
Rui-Xia Zhang
Jian-Qun Fang
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Obsessive-Compulsive Disorder
Published in: BMC Psychiatry / Issue 1/2021
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-021-03612-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Correlational research on facial and clinical characteristics of adolescents with obsessive-compulsive disorder

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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