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01-12-2021 | Intense Pulsed Light | Research

Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study

Authors: Zhinan Li, Junhao Chen, Yigang Feng, Shuming Zhong, Shui Tian, Zhongpeng Dai, Qing Lu, Yufang Guan, Yanyan Shan, Yanbin Jia

Published in: BMC Psychiatry | Issue 1/2021

Abstract

Background

Depressive symptoms could be similarly expressed in bipolar and unipolar disorder. However, changes in cognition and brain networks might be quite distinct. We aimed to find out the difference in the neural mechanism of impaired working memory in patients with bipolar and unipolar disorder.

Method

According to diagnostic criteria of bipolar II disorder of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and assessments, 13 bipolar II depression (BP II), 8 unipolar depression (UD) patients and 15 healthy controls (HC) were recruited in the study. We used 2-back tasks and magnetic source imaging (MSI) to test working memory functions and get the brain reactions of the participants.

Results

Compared with HC, only spatial working memory tasks accuracy was significantly worse in both UD and BP II (p = 0.001). Pearson correlation showed that the stronger the FCs’ strength of MFG-IPL and IPL-preSMA, the higher accuracy of SWM task within left FPN in patients with UD (r = 0.860, p = 0.006; r = 0.752, p = 0.031). However, the FC strength of IFG-IPL was negatively correlated with the accuracy of SWM task within left FPN in patients with BP II (r = − 0.591, p = 0.033).

Conclusions

Our study showed that the spatial working memory of patients with whether UD or BP II was impaired. The patterns of FCs within these two groups of patients were different when performing working memory tasks.

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Title: Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study
Authors: Zhinan Li
Junhao Chen
Yigang Feng
Shuming Zhong
Shui Tian
Zhongpeng Dai
Qing Lu
Yufang Guan
Yanyan Shan
Yanbin Jia
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Intense Pulsed Light
Mood Disorders
Magnetoencephalography
Affective Disorder
Published in: BMC Psychiatry / Issue 1/2021
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-021-03595-3

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Springer Medicine

Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study

Abstract

Background

Method

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Results

Conclusions

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