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BMC Psychiatry

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01-12-2021 | Endoscopy | Research

The association between depression and esophageal cancer in China: a multicentre population-based study

Authors: Juan Zhu, Shanrui Ma, Yueyue Zhou, Ru Chen, Shuanghua Xie, Zhengkui Liu, Xinqing Li, Wenqiang Wei

Published in: BMC Psychiatry | Issue 1/2021

Abstract

Background

Esophageal cancer (EC) is one of the leading contributors to the global burden of cancer, and the underlying mechanism is still unknown. Recently, there has been a growing interest in understanding modifiable psychosocial risk factors, particularly depression, to prevent EC and reduce morbidity and mortality. However, related research is sparse and has been ignored. The study was designed to assess the association between depression and EC in China.

Methods

From 2017 to 2019, a population-based multicenter study was conducted in high-risk regions of EC. Participants underwent a free endoscopy screening. If the endoscopic results were suspicious, a pathological biopsy was applied to confirm. Depression was measured with Patient Health Questionnaire-9 (PHQ-9). In addition, information on demographic characteristics and risk factors was collected from participants by trained interviewers using uniform questionnaires.

Results

After Endoscopy and pathologic diagnosis, 15,936 participants in high-risk regions of EC (ECHRRs) were enrolled, 10,907 (68.44%) of which were diagnosed health, 4048 (25.40%) with esophagitis, 769 (4.83%) with low-grade intraepithelial neoplasia (LGIN), 157 (0.99%) with high-grade intraepithelial neoplasia (HGIN), and 55 (0.35%) with EC, respectively. The overall prevalence of depression symptoms of participants was 4.16% (health: 4.63%, esophagitis: 2.99%, LGIN: 2.99%, HGIN: 5.73%, and EC: 9.09%). Multiple logistic regression analyses revealed that the unadjusted OR (95% CI) between depression and each esophageal pathology grades were esophagitis 0.93 (0.92-0.95), LGIN 0.97 (0.94-0.99), HGIN 1.05 (1.00-1.10), and EC 1.04 (0.97-1.14), respectively. However, after adjustment for potential confounders (age, gender, region, alcohol consumption, BMI), no statistically significant associations between depression and EC (adjusted OR = 1.10, 0.99-1.21) and esophageal lesions (esophagitis: adjusted OR = 1.02, 0.99-1.04; LGIN: adjusted OR = 0.98, 0.95-1.01; HGIN: adjusted OR = 1.04, 0.98-1.11) were observed in this study.

Conclusions

No significant association was observed between depression and EC in the study. Future prospective cohort studies are needed to verify this preliminary finding.

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Title: The association between depression and esophageal cancer in China: a multicentre population-based study
Authors: Juan Zhu
Shanrui Ma
Yueyue Zhou
Ru Chen
Shuanghua Xie
Zhengkui Liu
Xinqing Li
Wenqiang Wei
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Endoscopy
Esophageal Cancer
Mood Disorders
Esophagitis
Esophageal Cancer
Affective Disorder
Published in: BMC Psychiatry / Issue 1/2021
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-021-03534-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The association between depression and esophageal cancer in China: a multicentre population-based study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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