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BMC Psychiatry
Published in: BMC Psychiatry 1/2019

Open Access 01-12-2019 | Care | Study protocol

Affective dysregulation in childhood - optimizing prevention and treatment: protocol of three randomized controlled trials in the ADOPT study

Authors: Manfred Döpfner, Josepha Katzmann, Charlotte Hanisch, Jörg M. Fegert, Michael Kölch, Anne Ritschel, Anne-Katrin Treier, Martin Hellmich, Veit Roessner, Ulrike Ravens-Sieberer, Tobias Banaschewski, Anja Görtz-Dorten, on behalf of the ADOPT Consortium

Published in: BMC Psychiatry | Issue 1/2019

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Abstract

Background

The terms affective dysregulation (AD) and irritability describe transdiagnostic dimensions and are characterized by an excessive reactivity to negative emotional stimuli with an affective (anger) and a behavioral component (aggression). Due to early onset, high prevalence and persistence, as well as developmental comorbidity, AD in childhood is one of the most psychosocially impairing and cost-intensive mental health conditions. AD is especially prevalent in children in the youth welfare service. Despite continuous research, there remains a substantial need for diagnostic approaches and optimization of individualized treatment strategies in order to improve outcomes and reduce the subjective and economic burden.

Methods

The ADOPT (Affective Dysregulation – Optimizing Prevention and Treatment) Consortium integrates internationally established, highly experienced and interdisciplinary research groups. The work program encompasses (a) epidemiology, including prevalence of symptoms and disorders, (b) development and evaluation of screening and assessment tools, (c) stepped care approaches for clinically useful personalized medicine, (d) evaluation of an easily accessible and cost-effective online intervention as indicated prevention (treatment effects, moderation/mediation analysis), and (e) evaluation of an intensive personalized modular outpatient treatment in a cohort of children with AD who live with their parents and in a cohort of children with AD who live in out-of-home care (treatment effects, moderation/mediation analysis).

Discussion

The results will lead to significant recommendations for improving treatment within routine clinical care in two cohorts of children with AD and coexisting conditions, especially oppositional-defiant disorder, conduct disorder and disruptive mood dysregulation disorder.

Trial registration

Trial registration ADOPT Online: German Clinical Trials Register (DRKS) DRKS00014963. Registered 27 June 2018.
Trial registration ADOPT Treatment: German Clinical Trials Register (DRKS) DRKS00013317. Registered 27 September 2018.
Trial registration ADOPT Institution: German Clinical Trials Register (DRKS) DRKS00014581. Registered 04 July 2018.
Appendix
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Metadata
Title
Affective dysregulation in childhood - optimizing prevention and treatment: protocol of three randomized controlled trials in the ADOPT study
Authors
Manfred Döpfner
Josepha Katzmann
Charlotte Hanisch
Jörg M. Fegert
Michael Kölch
Anne Ritschel
Anne-Katrin Treier
Martin Hellmich
Veit Roessner
Ulrike Ravens-Sieberer
Tobias Banaschewski
Anja Görtz-Dorten
on behalf of the ADOPT Consortium
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Care
Published in
BMC Psychiatry / Issue 1/2019
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-019-2239-8

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