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Open Access 01-12-2019 | Affective Disorder | Research article

Gender-disease interaction on brain cerebral metabolism in cancer patients with depressive symptoms

Authors: Zhijun Yao, Lei Fang, Yue Yu, Zhe Zhang, Weihao Zheng, Zhihao Li, Yuan Li, Yu Zhao, Tao Hu, Zicheng Zhang, Bin Hu

Published in: BMC Psychiatry | Issue 1/2019

Abstract

Background

Cancer patients are accompanied with high morbidity of depression, and gender effects are known to inhabit in the depressive episodes. This study aimed to explore the gender effects in cancer patients, and the relationship between gender-cancer factors and the depression symptoms.

Methods

The 18F-FDG PET scans of 49 cancer patients and 48 normal controls were included. We used voxel-wise analysis to explore the effects of cancer factor and gender factor in cerebral glucose metabolism. Beck Depression Inventory was utilized to quantify the depression symptoms in cancer patients.

Results

Our results showed significant cancer main effects primarily in superior frontal gyrus and parietal gyrus; and significant gender main effects primarily in cerebellum posterior lobe, inferior temporal gyrus. Significant gender-by-cancer interaction effects were also observed, which primarily located in superior frontal gyrus. We showed the metabolic intensities of the 5 aforementioned clusters were related to the mental stress of depressive emotion.

Conclusions

Our results suggested that males and females have different psychological endurance when facing cancer diagnosis or preventing depression. Furthermore, the cerebral abnormal metabolism might serve as a depressive indicator for cancer patients. The present findings provided supporting evidence for abnormal cerebral glucose metabolism affected by gender factor in cancer patients with mental stress of depressive emotion, and these brain regions should be concerned in clinic.

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Title: Gender-disease interaction on brain cerebral metabolism in cancer patients with depressive symptoms
Authors: Zhijun Yao
Lei Fang
Yue Yu
Zhe Zhang
Weihao Zheng
Zhihao Li
Yuan Li
Yu Zhao
Tao Hu
Zicheng Zhang
Bin Hu
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Affective Disorder
Affective Disorder
Positron Emission Tomography
Published in: BMC Psychiatry / Issue 1/2019
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-018-2002-6

At a glance: The STEP trials

Springer Medicine

Gender-disease interaction on brain cerebral metabolism in cancer patients with depressive symptoms

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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