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Published in: BMC Psychiatry 1/2018

Open Access 01-12-2018 | Research article

Childhood adversities are different in Schizophrenic Spectrum Disorders, Bipolar Disorder and Major Depressive Disorder

Authors: Antonella Bruni, Elvira Anna Carbone, Valentina Pugliese, Matteo Aloi, Giuseppina Calabrò, Gregorio Cerminara, Cristina Segura-García, Pasquale De Fazio

Published in: BMC Psychiatry | Issue 1/2018

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Abstract

Background

Research has shown that a history of childhood adversities is common in patients with psychiatric disorders but few studies have investigated links between specific types of adversity and specific psychiatric disorders.

Methods

We investigated the frequency of early childhood adversities in a sample consisting of 91 patients with diagnosis of schizophrenic spectrum disorders (SSD), 74 patients with bipolar disorder (BD), 83 patients with major depressive disorder (MDD) and 85 healthy controls and sought to identify adverse early childhood life events that predict the development of major psychiatric disorders. The Childhood Experiences of Care and Abuse questionnaire was used to collect data on traumatic experiences occurring before the age of 17 years and comprehensive demographic data were also collected. The data were analyzed with chi-squared tests, t-tests, post-hoc and logistic regression.

Results

Maternal absence/loss and economic difficulties in the early life were more prevalent in the BD group than other groups. Escape from home, cannabis abuse, psychological abuse, physical abuse and loneliness were more frequent in the SSD group than in other groups. Paternal absence, neglect of core needs, serious familial tension and absence of adult and peer confidants were all less common in the HC group than in the other groups. The regression model confirmed that different types of adversities play a crucial role in the development of the three investigated disorders.

Conclusions

Our results support that SSD, BD and MDD are associated to different childhood adversities. This suggests that psychosocial interventions that reduce the incidence of these early life adversities might reduce the incidence of severe and disabling psychiatric disorders.
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Literature
1.
go back to reference Matheson SL, Shepherd AM, Laurens KR, Carr VJ. A systematic meta-review grading the evidence for non-genetic risk factors and putative antecedents of schizophrenia. Schizophr Res. 2011;133:133–42.CrossRef Matheson SL, Shepherd AM, Laurens KR, Carr VJ. A systematic meta-review grading the evidence for non-genetic risk factors and putative antecedents of schizophrenia. Schizophr Res. 2011;133:133–42.CrossRef
2.
go back to reference Brown AS. The environment and susceptibility to schizophrenia. Prog Neurobiol. 2011;93:23–58.CrossRef Brown AS. The environment and susceptibility to schizophrenia. Prog Neurobiol. 2011;93:23–58.CrossRef
3.
go back to reference Brown AS, Derkits EJ. Prenatal infection and schizophrenia: a review of epidemiologic and translational studies. Am J Psychiatry. 2010;167:261–80.CrossRef Brown AS, Derkits EJ. Prenatal infection and schizophrenia: a review of epidemiologic and translational studies. Am J Psychiatry. 2010;167:261–80.CrossRef
4.
go back to reference Bendall S, Jackson HJ, Hulbert CA, McGorry PD. Childhood trauma and psychotic disorders: a systematic, critical review of the evidence. Schizophr Bull. 2008;34:568–79.CrossRef Bendall S, Jackson HJ, Hulbert CA, McGorry PD. Childhood trauma and psychotic disorders: a systematic, critical review of the evidence. Schizophr Bull. 2008;34:568–79.CrossRef
5.
go back to reference Walder DJ, Faraone SV, Glatt SJ, Tsuang MT, Seidman LJ. Genetic liability, prenatal health, stress and family environment: risk factors in the Harvard adolescent family high risk for schizophrenia study. Schizophr Res. 2014;157:142–8.CrossRef Walder DJ, Faraone SV, Glatt SJ, Tsuang MT, Seidman LJ. Genetic liability, prenatal health, stress and family environment: risk factors in the Harvard adolescent family high risk for schizophrenia study. Schizophr Res. 2014;157:142–8.CrossRef
6.
go back to reference Fusar-Poli P, Tantardini M, De Simone S, Ramella-Cravaro V, Oliver D, Kingdon J, et al. Deconstructing vulnerability for psychosis: meta-analysis of environmental risk factors for psychosis in subjects at ultra high-risk. Eur Psychiatry. 2017;40:65–75.CrossRef Fusar-Poli P, Tantardini M, De Simone S, Ramella-Cravaro V, Oliver D, Kingdon J, et al. Deconstructing vulnerability for psychosis: meta-analysis of environmental risk factors for psychosis in subjects at ultra high-risk. Eur Psychiatry. 2017;40:65–75.CrossRef
7.
go back to reference Uher R. Gene-environment interactions in severe mental illness. Front Psychiatry. 2014;5:1–9.CrossRef Uher R. Gene-environment interactions in severe mental illness. Front Psychiatry. 2014;5:1–9.CrossRef
8.
go back to reference Cancel A, Comte M, Boutet C, Schneider FC, Rousseau P-F, Boukezzi S, et al. Childhood trauma and emotional processing circuits in schizophrenia: a functional connectivity study. Schizophr Res. 2017;184:69–72.CrossRef Cancel A, Comte M, Boutet C, Schneider FC, Rousseau P-F, Boukezzi S, et al. Childhood trauma and emotional processing circuits in schizophrenia: a functional connectivity study. Schizophr Res. 2017;184:69–72.CrossRef
9.
go back to reference Alameda L, Ferrari C, Baumann PS, Gholam-Rezaee M, Do KQ, Conus P. Childhood sexual and physical abuse: age at exposure modulates impact on functional outcome in early psychosis patients. Psychol Med. 2015;45:2727–36.CrossRef Alameda L, Ferrari C, Baumann PS, Gholam-Rezaee M, Do KQ, Conus P. Childhood sexual and physical abuse: age at exposure modulates impact on functional outcome in early psychosis patients. Psychol Med. 2015;45:2727–36.CrossRef
10.
go back to reference Janssen I, Krabbendam L, Bak M, Hanssen M, Vollebergh W, de Graaf R, et al. Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatr Scand. 2004;109:38–45.CrossRef Janssen I, Krabbendam L, Bak M, Hanssen M, Vollebergh W, de Graaf R, et al. Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatr Scand. 2004;109:38–45.CrossRef
11.
go back to reference Matheson SL, Vijayan H, Dickson H, Shepherd AM, Carr VJ, Laurens KR. Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9-14 years. J Psychiatr Res. 2013;47:1061–8.CrossRef Matheson SL, Vijayan H, Dickson H, Shepherd AM, Carr VJ, Laurens KR. Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9-14 years. J Psychiatr Res. 2013;47:1061–8.CrossRef
12.
go back to reference Rubino IA, Nanni RC, Pozzi DM, Siracusano A. Early adverse experiences in schizophrenia and unipolar depression. J Nerv Ment Dis. 2009;197:65–8.CrossRef Rubino IA, Nanni RC, Pozzi DM, Siracusano A. Early adverse experiences in schizophrenia and unipolar depression. J Nerv Ment Dis. 2009;197:65–8.CrossRef
13.
go back to reference Patten SB, Wilkes TCR, Williams JVA, Lavorato DH, El-Guebaly N, Schopflocher D, et al. Retrospective and prospectively assessed childhood adversity in association with major depression, alcohol consumption and painful conditions. Epidemiol Psychiatr Sci. 2015;24:158–65.CrossRef Patten SB, Wilkes TCR, Williams JVA, Lavorato DH, El-Guebaly N, Schopflocher D, et al. Retrospective and prospectively assessed childhood adversity in association with major depression, alcohol consumption and painful conditions. Epidemiol Psychiatr Sci. 2015;24:158–65.CrossRef
14.
go back to reference Palmier-Claus JE, Berry K, Bucci S, Mansell W, Varese F. Relationship between childhood adversity and bipolar affective disorder: systematic review and meta-analysis. Br J Psychiatry. 2016;209:454–9.CrossRef Palmier-Claus JE, Berry K, Bucci S, Mansell W, Varese F. Relationship between childhood adversity and bipolar affective disorder: systematic review and meta-analysis. Br J Psychiatry. 2016;209:454–9.CrossRef
15.
go back to reference Xie P, Wu K, Zheng Y, Guo Y, Yang Y, He J, et al. Prevalence of childhood trauma and correlations between childhood trauma, suicidal ideation, and social support in patients with depression, bipolar disorder, and schizophrenia in southern China. J Affect Disord. 2018;228:41–8.CrossRef Xie P, Wu K, Zheng Y, Guo Y, Yang Y, He J, et al. Prevalence of childhood trauma and correlations between childhood trauma, suicidal ideation, and social support in patients with depression, bipolar disorder, and schizophrenia in southern China. J Affect Disord. 2018;228:41–8.CrossRef
16.
go back to reference American Psychiatric Association. DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders, 4th ed.Revised. 2000. American Psychiatric Association. DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders, 4th ed.Revised. 2000.
17.
go back to reference First M, Spitzer R, Gibbon M, Williams J. Structured clinical interview for DSM-IV-TR Axis I disorders (SCID-I). in: New York, NY: New York State Psychiatric Institute Biometrics Research. 1995. First M, Spitzer R, Gibbon M, Williams J. Structured clinical interview for DSM-IV-TR Axis I disorders (SCID-I). in: New York, NY: New York State Psychiatric Institute Biometrics Research. 1995.
18.
go back to reference European Network of National Networks studying Gene-Environment Interactions in Schizophrenia (EU-GEI), van Os J, Rutten BP, Myin-Germeys I, Delespaul P, Viechtbauer W, et al. Identifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations. Schizophr Bull. 2014;40:729–36.CrossRef European Network of National Networks studying Gene-Environment Interactions in Schizophrenia (EU-GEI), van Os J, Rutten BP, Myin-Germeys I, Delespaul P, Viechtbauer W, et al. Identifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations. Schizophr Bull. 2014;40:729–36.CrossRef
19.
go back to reference Gayer-Anderson C, Fisher HL, Fearon P, Hutchinson G, Morgan K, Dazzan P, et al. Gender differences in the association between childhood physical and sexual abuse, social support and psychosis. Soc Psychiatry Psychiatr Epidemiol. 2015;50:1489–500.CrossRef Gayer-Anderson C, Fisher HL, Fearon P, Hutchinson G, Morgan K, Dazzan P, et al. Gender differences in the association between childhood physical and sexual abuse, social support and psychosis. Soc Psychiatry Psychiatr Epidemiol. 2015;50:1489–500.CrossRef
20.
go back to reference Sweeney S, Air T, Zannettino L, Galletly C. Gender Differences in the Physical and Psychological Manifestation of Childhood Trauma and/or Adversity in People with Psychosis. Front Psychol. 2015;6:1768. Sweeney S, Air T, Zannettino L, Galletly C. Gender Differences in the Physical and Psychological Manifestation of Childhood Trauma and/or Adversity in People with Psychosis. Front Psychol. 2015;6:1768.
21.
go back to reference Read J, Perry BD, Moskowitz A, Connolly J. The contribution of early traumatic events to schizophrenia in some patients: a traumagenic neurodevelopmental model. Psychiatry. 2001;64:319–45.CrossRef Read J, Perry BD, Moskowitz A, Connolly J. The contribution of early traumatic events to schizophrenia in some patients: a traumagenic neurodevelopmental model. Psychiatry. 2001;64:319–45.CrossRef
22.
go back to reference Klein LC, Corwin EJ. Seeing the unexpected: how sex differences in stress responses may provide a new perspective on the manifestation of psychiatric disorders. Curr Psychiatry Rep. 2002;4:441–8.CrossRef Klein LC, Corwin EJ. Seeing the unexpected: how sex differences in stress responses may provide a new perspective on the manifestation of psychiatric disorders. Curr Psychiatry Rep. 2002;4:441–8.CrossRef
23.
go back to reference Taylor SE, Klein LC, Lewis BP, Gruenewald TL, Gurung RA, Updegraff JA. Biobehavioral responses to stress in females: tend-and-befriend, not fight-or-flight. Psychol Rev. 2000;107:411–29.CrossRef Taylor SE, Klein LC, Lewis BP, Gruenewald TL, Gurung RA, Updegraff JA. Biobehavioral responses to stress in females: tend-and-befriend, not fight-or-flight. Psychol Rev. 2000;107:411–29.CrossRef
24.
go back to reference Misiak B, Krefft M, Bielawski T, Moustafa AA, Sąsiadek MM, Frydecka D. Toward a unified theory of childhood trauma and psychosis: a comprehensive review of epidemiological, clinical, neuropsychological and biological findings. Neurosci Biobehav Rev. 2017;75:393–406.CrossRef Misiak B, Krefft M, Bielawski T, Moustafa AA, Sąsiadek MM, Frydecka D. Toward a unified theory of childhood trauma and psychosis: a comprehensive review of epidemiological, clinical, neuropsychological and biological findings. Neurosci Biobehav Rev. 2017;75:393–406.CrossRef
25.
go back to reference Trauelsen AM, Bendall S, Jansen JE, Nielsen H-GL, Pedersen MB, Trier CH, et al. Childhood adversities: social support, premorbid functioning and social outcome in first-episode psychosis and a matched case-control group. Aust New Zeal J Psychiatry. 2016;50:770–82.CrossRef Trauelsen AM, Bendall S, Jansen JE, Nielsen H-GL, Pedersen MB, Trier CH, et al. Childhood adversities: social support, premorbid functioning and social outcome in first-episode psychosis and a matched case-control group. Aust New Zeal J Psychiatry. 2016;50:770–82.CrossRef
26.
go back to reference Gil A, Gama CS, de Jesus DR, Lobato MI, Zimmer M, Belmonte-de-Abreu P. The association of child abuse and neglect with adult disability in schizophrenia and the prominent role of physical neglect. Child Abuse Negl. 2009;33:618–24.CrossRef Gil A, Gama CS, de Jesus DR, Lobato MI, Zimmer M, Belmonte-de-Abreu P. The association of child abuse and neglect with adult disability in schizophrenia and the prominent role of physical neglect. Child Abuse Negl. 2009;33:618–24.CrossRef
27.
go back to reference Raune D, Kuipers E, Bebbington P. Stressful and intrusive life events preceding first episode psychosis. Epidemiol Psichiatr Soc. 18:221–8. Raune D, Kuipers E, Bebbington P. Stressful and intrusive life events preceding first episode psychosis. Epidemiol Psichiatr Soc. 18:221–8.
28.
go back to reference Varese F, Smeets F, Drukker M, Lieverse R, Lataster T, Viechtbauer W, et al. Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective-and cross-sectional cohort studies. Schizophr Bull. 2012;38:661–71.CrossRef Varese F, Smeets F, Drukker M, Lieverse R, Lataster T, Viechtbauer W, et al. Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective-and cross-sectional cohort studies. Schizophr Bull. 2012;38:661–71.CrossRef
29.
go back to reference Morgan C, Reininghaus U, Reichenberg A, Frissa S, Hotopf M, Hatch SL. Adversity, cannabis use and psychotic experiences: evidence of cumulative and synergistic effects. Br J Psychiatry. 2014;204:346–53.CrossRef Morgan C, Reininghaus U, Reichenberg A, Frissa S, Hotopf M, Hatch SL. Adversity, cannabis use and psychotic experiences: evidence of cumulative and synergistic effects. Br J Psychiatry. 2014;204:346–53.CrossRef
30.
go back to reference Morgan C, Gayer-Anderson C. Childhood adversities and psychosis: evidence, challenges, implications. World Psychiatry. 2016;15:93–102.CrossRef Morgan C, Gayer-Anderson C. Childhood adversities and psychosis: evidence, challenges, implications. World Psychiatry. 2016;15:93–102.CrossRef
31.
go back to reference Etain B, Henry C, Bellivier F, Mathieu F, Leboyer M. Beyond genetics: childhood affective trauma in bipolar disorder. Bipolar Disord. 2008;10:867–76.CrossRef Etain B, Henry C, Bellivier F, Mathieu F, Leboyer M. Beyond genetics: childhood affective trauma in bipolar disorder. Bipolar Disord. 2008;10:867–76.CrossRef
32.
go back to reference Laursen TM, Munk-Olsen T, Nordentoft M, Bo MP. A comparison of selected risk factors for unipolar depressive disorder, bipolar affective disorder, schizoaffective disorder, and schizophrenia from a danish population-based cohort. J Clin Psychiatry. 2007;68:1673–81.CrossRef Laursen TM, Munk-Olsen T, Nordentoft M, Bo MP. A comparison of selected risk factors for unipolar depressive disorder, bipolar affective disorder, schizoaffective disorder, and schizophrenia from a danish population-based cohort. J Clin Psychiatry. 2007;68:1673–81.CrossRef
33.
go back to reference Mortensen PB, Pedersen CB, Melbye M, Mors O, Ewald H. Individual and familial risk factors for bipolar affective disorders in Denmark. Arch Gen Psychiatry. 2003;60:1209.CrossRef Mortensen PB, Pedersen CB, Melbye M, Mors O, Ewald H. Individual and familial risk factors for bipolar affective disorders in Denmark. Arch Gen Psychiatry. 2003;60:1209.CrossRef
34.
go back to reference Read J, van Os J, Morrison AP, Ross CA. Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr Scand. 2005;112:330–50.CrossRef Read J, van Os J, Morrison AP, Ross CA. Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr Scand. 2005;112:330–50.CrossRef
35.
go back to reference Watson S, Porter RJ. Childhood adversity in bipolar disorder. Aust New Zeal J Psychiatry. 2014;48:975–6.CrossRef Watson S, Porter RJ. Childhood adversity in bipolar disorder. Aust New Zeal J Psychiatry. 2014;48:975–6.CrossRef
36.
go back to reference Etain B, Mathieu F, Henry C, Raust A, Roy I, Germain A, et al. Preferential association between childhood emotional abuse and bipolar disorder. J Trauma Stress. 2010;23:376–83.PubMed Etain B, Mathieu F, Henry C, Raust A, Roy I, Germain A, et al. Preferential association between childhood emotional abuse and bipolar disorder. J Trauma Stress. 2010;23:376–83.PubMed
37.
go back to reference Nomura Y, Wickramaratne PJ, Warner V, Mufson L, Weissman MM. Family discord, parental depression, and psychopathology in offspring: ten-year follow-up. J Am Acad Child Adolesc Psychiatry. 2002;41:402–9.CrossRef Nomura Y, Wickramaratne PJ, Warner V, Mufson L, Weissman MM. Family discord, parental depression, and psychopathology in offspring: ten-year follow-up. J Am Acad Child Adolesc Psychiatry. 2002;41:402–9.CrossRef
38.
go back to reference Reinherz HZ, Giaconia RM, Hauf AM, Wasserman MS, Silverman AB. Major depression in the transition to adulthood: risks and impairments. J Abnorm Psychol. 1999;108:500–10.CrossRef Reinherz HZ, Giaconia RM, Hauf AM, Wasserman MS, Silverman AB. Major depression in the transition to adulthood: risks and impairments. J Abnorm Psychol. 1999;108:500–10.CrossRef
39.
go back to reference Jaffee SR, Moffitt TE, Caspi A, Fombonne E, Poulton R, Martin J. Differences in early childhood risk factors for juvenile-onset and adult-onset depression. Arch Gen Psychiatry. 2002;59:215–22.CrossRef Jaffee SR, Moffitt TE, Caspi A, Fombonne E, Poulton R, Martin J. Differences in early childhood risk factors for juvenile-onset and adult-onset depression. Arch Gen Psychiatry. 2002;59:215–22.CrossRef
40.
go back to reference Spence SH, Najman JM, Bor W, O’Callaghan MJ, Williams GM. Maternal anxiety and depression, poverty and marital relationship factors during early childhood as predictors of anxiety and depressive symptoms in adolescence. J Child Psychol Psychiatry. 2002;43:457–69.CrossRef Spence SH, Najman JM, Bor W, O’Callaghan MJ, Williams GM. Maternal anxiety and depression, poverty and marital relationship factors during early childhood as predictors of anxiety and depressive symptoms in adolescence. J Child Psychol Psychiatry. 2002;43:457–69.CrossRef
41.
go back to reference Weich S, Patterson J, Shaw R, Stewart-Brown S. Family relationships in childhood and common psychiatric disorders in later life: systematic review of prospective studies. Br J Psychiatry. 2009;194:392–8.CrossRef Weich S, Patterson J, Shaw R, Stewart-Brown S. Family relationships in childhood and common psychiatric disorders in later life: systematic review of prospective studies. Br J Psychiatry. 2009;194:392–8.CrossRef
Metadata
Title
Childhood adversities are different in Schizophrenic Spectrum Disorders, Bipolar Disorder and Major Depressive Disorder
Authors
Antonella Bruni
Elvira Anna Carbone
Valentina Pugliese
Matteo Aloi
Giuseppina Calabrò
Gregorio Cerminara
Cristina Segura-García
Pasquale De Fazio
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2018
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-018-1972-8

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