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BMC Psychiatry
Published in: BMC Psychiatry 1/2017

Open Access 01-12-2017 | Review

Antidepressant prescribing in the precision medicine era: a prescriber’s primer on pharmacogenetic tools

Authors: Chad A. Bousman, Malcolm Forbes, Mahesh Jayaram, Harris Eyre, Charles F. Reynolds, Michael Berk, Malcolm Hopwood, Chee Ng

Published in: BMC Psychiatry | Issue 1/2017

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Abstract

About half of people who take antidepressants do not respond and many experience adverse effects. These detrimental outcomes are in part a result of the impact of an individual’s genetic profile on pharmacokinetics and pharmcodynamics. If known and made available to clinicians, this could improve decision-making and antidepressant therapy outcomes. This has spurred the development of numerous pharmacogenetic-based decision support tools. In this article, we provide an overview of pharmacogenetic decision support tools, with particular focus on tools relevant to antidepressants. We briefly describe the evolution and current state of antidepressant pharmacogenetic decision support tools in clinical practice, followed by the evidence-base for their use. Finally, we present a series of considerations for clinicians contemplating use of these tools and discuss the future of antidepressant pharmacogenetic decision support tools.
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Metadata
Title
Antidepressant prescribing in the precision medicine era: a prescriber’s primer on pharmacogenetic tools
Authors
Chad A. Bousman
Malcolm Forbes
Mahesh Jayaram
Harris Eyre
Charles F. Reynolds
Michael Berk
Malcolm Hopwood
Chee Ng
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2017
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-017-1230-5

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