Skip to main content
Top
Published in: BMC Psychiatry 1/2017

Open Access 01-12-2017 | Research article

Assessing the risk for suicide in schizophrenia according to migration, ethnicity and geographical ancestry

Authors: Nuwan C. Hettige, Ali Bani-Fatemi, James L. Kennedy, Vincenzo De Luca

Published in: BMC Psychiatry | Issue 1/2017

Login to get access

Abstract

Background

Suicide is a leading cause of mortality among those afflicted by schizophrenia. Previous studies demonstrated that the stressors associated with immigration may lead to an onset of schizophrenia and suicide separately in susceptible individuals. However, no studies have shown whether immigration may lead to suicidal behaviour for individuals with schizophrenia. Our study proposes that an individual’s geographical ancestry, ethnicity or migration status may be predictive of suicide risk in schizophrenia.

Methods

In a sample of 276 participants with schizophrenia spectrum disorders, we conducted cross-sectional assessments to collect clinical information. Self-identified ethnicity and suicide history were collected through self-report questionnaires and interview-based scales. Ancestry was identified using 292 genetic markers from HapMap. Migrants were classified as those who immigrated to Canada during their lifetime. Using a regression analysis, we tested whether a history of migration, ethnicity or geographical ancestry were predictive of a history of suicide attempts.

Results

Our analysis failed to demonstrate a significant relationship between suicide history and migration, ethnicity or ancestry. However, ethnicity appears to be significantly associated with the number of psychiatric hospitalizations in our sample.

Conclusion

Ethnicity and migration history are not predictive of previous suicide attempts. Ethnicity may be an important demographic factor affecting access to mental health resources and frequency of hospitalizations.
Literature
3.
go back to reference Saha S, Chant D, McGrath J. A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry. 2007;64:1123–31.CrossRefPubMed Saha S, Chant D, McGrath J. A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry. 2007;64:1123–31.CrossRefPubMed
4.
go back to reference Dealberto MJ. Are the rates of schizophrenia unusually high in Canada? A comparison of Canadian and international data. Psychiatry Res. 2013;209(3):259–65.CrossRefPubMed Dealberto MJ. Are the rates of schizophrenia unusually high in Canada? A comparison of Canadian and international data. Psychiatry Res. 2013;209(3):259–65.CrossRefPubMed
5.
go back to reference Holder SD, Wayhs A. Schizophrenia. Am Fam Physician. 2014;90(11):775–82.PubMed Holder SD, Wayhs A. Schizophrenia. Am Fam Physician. 2014;90(11):775–82.PubMed
6.
go back to reference Fletcher PC, Frith CD. Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia. Nat Rev Neurosci. 2009;10(1):48–58.CrossRefPubMed Fletcher PC, Frith CD. Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia. Nat Rev Neurosci. 2009;10(1):48–58.CrossRefPubMed
7.
go back to reference Phan SV, Kreys TJ. Adjunct mirtazapine for negative symptoms of schizophrenia. Pharmacotherapy. 2011;31(10):1017–30.CrossRefPubMed Phan SV, Kreys TJ. Adjunct mirtazapine for negative symptoms of schizophrenia. Pharmacotherapy. 2011;31(10):1017–30.CrossRefPubMed
8.
go back to reference Hovington CL, Lepage M. Neurocognition and neuroimaging of persistent negative symptoms of schizophrenia. Expert Rev Neurother. 2012;12(1):53–69.CrossRefPubMed Hovington CL, Lepage M. Neurocognition and neuroimaging of persistent negative symptoms of schizophrenia. Expert Rev Neurother. 2012;12(1):53–69.CrossRefPubMed
9.
go back to reference Brown S, Inskip H, Barraclough B. Causes of the excess mortality of schizophrenia. Br J Psychiatry. 2000;177:212–7.CrossRefPubMed Brown S, Inskip H, Barraclough B. Causes of the excess mortality of schizophrenia. Br J Psychiatry. 2000;177:212–7.CrossRefPubMed
10.
go back to reference Hawton K, Sutton L, Haw C, et al. Schizophrenia and suicide: systematic review of risk factors. Br J Psychiatry. 2005;187:9–20.CrossRefPubMed Hawton K, Sutton L, Haw C, et al. Schizophrenia and suicide: systematic review of risk factors. Br J Psychiatry. 2005;187:9–20.CrossRefPubMed
11.
go back to reference Palmer BA, Pankratz VS, Bostwick JM. The lifetime risk of suicide in schizophrenia - A reexamination. Arch Gen Psychiatry. 2005;62:247–53.CrossRefPubMed Palmer BA, Pankratz VS, Bostwick JM. The lifetime risk of suicide in schizophrenia - A reexamination. Arch Gen Psychiatry. 2005;62:247–53.CrossRefPubMed
12.
go back to reference Fleischhacker WW, Kane JM, Geier J, et al. Completed and attempted suicides among 18,154 subjects with schizophrenia included in a large simple trial. J Clin Psychiatry. 2014;75(3):e184–90.CrossRefPubMed Fleischhacker WW, Kane JM, Geier J, et al. Completed and attempted suicides among 18,154 subjects with schizophrenia included in a large simple trial. J Clin Psychiatry. 2014;75(3):e184–90.CrossRefPubMed
13.
go back to reference Pompili M, Amador XF, Girardi P, et al. Suicide risk in schizophrenia: learning from the past to change the future. Ann Gen Psychiatr. 2007;6:10.CrossRef Pompili M, Amador XF, Girardi P, et al. Suicide risk in schizophrenia: learning from the past to change the future. Ann Gen Psychiatr. 2007;6:10.CrossRef
14.
go back to reference Kirkbride JB, Jones PB, Ullrich S, et al. Social deprivation, inequality, and the neighborhood-level incidence of psychotic syndromes in East London. Schizophr Bull. 2014;40(1):169–80.CrossRefPubMed Kirkbride JB, Jones PB, Ullrich S, et al. Social deprivation, inequality, and the neighborhood-level incidence of psychotic syndromes in East London. Schizophr Bull. 2014;40(1):169–80.CrossRefPubMed
15.
go back to reference Fearon P, Kirkbride JB, Morgan C, AESOP Study Group, et al. Incidence of schizophrenia and other psychoses in ethnic minority groups: results from the MRC AESOP Study. Psychol Med. 2006;36(11):1541–50.CrossRefPubMed Fearon P, Kirkbride JB, Morgan C, AESOP Study Group, et al. Incidence of schizophrenia and other psychoses in ethnic minority groups: results from the MRC AESOP Study. Psychol Med. 2006;36(11):1541–50.CrossRefPubMed
16.
go back to reference Leão TS, Sundquist J, Frank G, et al. Incidence of schizophrenia or other psychoses in first- and second-generation immigrants: a national cohort study. J Nerv Ment Dis. 2006;194(1):27–33.CrossRefPubMed Leão TS, Sundquist J, Frank G, et al. Incidence of schizophrenia or other psychoses in first- and second-generation immigrants: a national cohort study. J Nerv Ment Dis. 2006;194(1):27–33.CrossRefPubMed
17.
go back to reference Li D, Law S, Andermann L. Association between degrees of social defeat and themes of delusion in patients with schizophrenia from immigrant and ethnic minority backgrounds. Transcult Psychiatry. 2012;49(5):735–49.CrossRefPubMed Li D, Law S, Andermann L. Association between degrees of social defeat and themes of delusion in patients with schizophrenia from immigrant and ethnic minority backgrounds. Transcult Psychiatry. 2012;49(5):735–49.CrossRefPubMed
18.
go back to reference Cantor-Graae E. The contribution of social factors to the development of schizophrenia: a review of recent findings. Can J Psychiatry. 2007;52(5):277–86.CrossRefPubMed Cantor-Graae E. The contribution of social factors to the development of schizophrenia: a review of recent findings. Can J Psychiatry. 2007;52(5):277–86.CrossRefPubMed
19.
go back to reference Das-Munshi J, Bécares L, Boydell JE, et al. Ethnic density as a buffer for psychotic experiences: findings from a national survey (EMPIRIC). Br J Psychiatry. 2012;201(4):282–90.CrossRefPubMedPubMedCentral Das-Munshi J, Bécares L, Boydell JE, et al. Ethnic density as a buffer for psychotic experiences: findings from a national survey (EMPIRIC). Br J Psychiatry. 2012;201(4):282–90.CrossRefPubMedPubMedCentral
20.
go back to reference Schofield P, Ashworth M, Jones R. Ethnic isolation and psychosis: re-examining the ethnic density effect. Psychol Med. 2011;41(6):1263–9.CrossRefPubMed Schofield P, Ashworth M, Jones R. Ethnic isolation and psychosis: re-examining the ethnic density effect. Psychol Med. 2011;41(6):1263–9.CrossRefPubMed
21.
go back to reference Kirkbride JB, Morgan C, Fearon P, et al. Neighbourhood-level effects on psychoses: re-examining the role of context. Psychol Med. 2007;37(10):1413–25.CrossRefPubMed Kirkbride JB, Morgan C, Fearon P, et al. Neighbourhood-level effects on psychoses: re-examining the role of context. Psychol Med. 2007;37(10):1413–25.CrossRefPubMed
22.
go back to reference van Os J. Psychotic experiences: disadvantaged and different from the norm. Br J Psychiatry. 2012;201(4):258–9.CrossRefPubMed van Os J. Psychotic experiences: disadvantaged and different from the norm. Br J Psychiatry. 2012;201(4):258–9.CrossRefPubMed
23.
go back to reference Veling W. Ethnic minority position and risk for psychotic disorders. Curr Opin Psychiatry. 2013;26(2):166–71.CrossRefPubMed Veling W. Ethnic minority position and risk for psychotic disorders. Curr Opin Psychiatry. 2013;26(2):166–71.CrossRefPubMed
24.
go back to reference Cantor-Graae E, Selten J. Schizophrenia and migration: a meta-analysis and review. Am J Psychiatry. 2005;162(1):12–24.CrossRefPubMed Cantor-Graae E, Selten J. Schizophrenia and migration: a meta-analysis and review. Am J Psychiatry. 2005;162(1):12–24.CrossRefPubMed
25.
go back to reference Malenfant EC. Suicide in Canada’s immigrant population. Health Rep. 2004;15(2):9–17.PubMed Malenfant EC. Suicide in Canada’s immigrant population. Health Rep. 2004;15(2):9–17.PubMed
26.
go back to reference Lipsicas CB, Makinen IH. Immigration and Suicidality in the Young. Can J Psychiatry. 2010;55(5):274–81.CrossRef Lipsicas CB, Makinen IH. Immigration and Suicidality in the Young. Can J Psychiatry. 2010;55(5):274–81.CrossRef
27.
go back to reference Bhugra D. Cultural identities and cultural congruency: a new model for evaluating mental distress in immigrants. Acta Psychiatr Scand. 2005;111(2):84–93.CrossRefPubMed Bhugra D. Cultural identities and cultural congruency: a new model for evaluating mental distress in immigrants. Acta Psychiatr Scand. 2005;111(2):84–93.CrossRefPubMed
28.
go back to reference Shoval G, Schoen G, Vardi N, et al. Suicide in Ethiopian immigrants in Israel: a case for study of the genetic-environmental relation in suicide. Arch Suicide Res. 2007;11(3):247–53.CrossRefPubMed Shoval G, Schoen G, Vardi N, et al. Suicide in Ethiopian immigrants in Israel: a case for study of the genetic-environmental relation in suicide. Arch Suicide Res. 2007;11(3):247–53.CrossRefPubMed
29.
go back to reference Berg AO, Andreassen OA, Aminoff SR, et al. The impact of immigration and visible minority status on psychosis symptom profile. Soc Psychiatry Psychiatr Epidemiol. 2014;49(11):1747–57.CrossRefPubMed Berg AO, Andreassen OA, Aminoff SR, et al. The impact of immigration and visible minority status on psychosis symptom profile. Soc Psychiatry Psychiatr Epidemiol. 2014;49(11):1747–57.CrossRefPubMed
30.
go back to reference Spallek J, Reeske A, Norredam M, et al. Suicide among immigrants in Europe--a systematic literature review. Eur J Public Health. 2015;25(1):63–71.CrossRefPubMed Spallek J, Reeske A, Norredam M, et al. Suicide among immigrants in Europe--a systematic literature review. Eur J Public Health. 2015;25(1):63–71.CrossRefPubMed
31.
go back to reference American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington: American Psychiatric Association; 2013.CrossRef American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington: American Psychiatric Association; 2013.CrossRef
32.
go back to reference Beck AT, Steer RA. Manual for Beck Scale for Suicidal Ideation. New York: Psychological Corporation; 1991. Beck AT, Steer RA. Manual for Beck Scale for Suicidal Ideation. New York: Psychological Corporation; 1991.
33.
go back to reference Posner K, Brown GK, Stanley B, et al. The Columbia-Suicide Severity Rating Scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults. Am J Psychiatry. 2011;168(12):1266–77.CrossRefPubMedPubMedCentral Posner K, Brown GK, Stanley B, et al. The Columbia-Suicide Severity Rating Scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults. Am J Psychiatry. 2011;168(12):1266–77.CrossRefPubMedPubMedCentral
34.
go back to reference R version 3.1.3 (2015-03-09) -- “Smooth Sidewalk” Copyright (C) 2015 The R Foundation for Statistical Computing Platform: x86_64-w64-mingw32/x64 (64-bit) R version 3.1.3 (2015-03-09) -- “Smooth Sidewalk” Copyright (C) 2015 The R Foundation for Statistical Computing Platform: x86_64-w64-mingw32/x64 (64-bit)
35.
go back to reference The International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature. 2007;449:851–61.CrossRefPubMedCentral The International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature. 2007;449:851–61.CrossRefPubMedCentral
37.
go back to reference Lindert J, Schouler-Ocak M, Heinz A, et al. Mental health, health care utilization of migrants in Europe. Eur Psychiatry. 2008;23 Suppl 1:14–20.CrossRefPubMed Lindert J, Schouler-Ocak M, Heinz A, et al. Mental health, health care utilization of migrants in Europe. Eur Psychiatry. 2008;23 Suppl 1:14–20.CrossRefPubMed
38.
go back to reference Bhui K, Stansfeld S, Hull S, et al. Ethnic variations in pathways to and use of specialist mental health services in the UK. Systematic Review. Br J Psychiatr. 2003;182:105–16.CrossRef Bhui K, Stansfeld S, Hull S, et al. Ethnic variations in pathways to and use of specialist mental health services in the UK. Systematic Review. Br J Psychiatr. 2003;182:105–16.CrossRef
39.
go back to reference Cole E, Leavey G, King M, et al. Pathways to care for patients with a first episode of psychosis: A comparison of ethnic groups. Br J Psychiatr. 1995;167:770–6.CrossRef Cole E, Leavey G, King M, et al. Pathways to care for patients with a first episode of psychosis: A comparison of ethnic groups. Br J Psychiatr. 1995;167:770–6.CrossRef
40.
go back to reference Morgan C, Mallett R, Hutchinson G, et al. Pathways to care and ethnicity 1: Sample characteristics and compulsory admissions. Report from the AESOP study. Br J Psychiatr. 2005;186:281–9.CrossRef Morgan C, Mallett R, Hutchinson G, et al. Pathways to care and ethnicity 1: Sample characteristics and compulsory admissions. Report from the AESOP study. Br J Psychiatr. 2005;186:281–9.CrossRef
41.
go back to reference Singh S, Greenwood N, White S, et al. Ethnicity and the Mental Health Act 1983: Systematic review. Br J Psychiatr. 2007;191:99–105.CrossRef Singh S, Greenwood N, White S, et al. Ethnicity and the Mental Health Act 1983: Systematic review. Br J Psychiatr. 2007;191:99–105.CrossRef
42.
go back to reference Qin P, Nordentoft M. Suicide risk in relation to psychiatric hospitalization: evidence based on longitudinal registers. Arch Gen Psychiatry. 2005;62(4):427–32.CrossRefPubMed Qin P, Nordentoft M. Suicide risk in relation to psychiatric hospitalization: evidence based on longitudinal registers. Arch Gen Psychiatry. 2005;62(4):427–32.CrossRefPubMed
43.
go back to reference Kao YC, Liu YP. Suicidal behavior and insight into illness among patients with schizophrenia spectrum disorders. Psychiatry Q. 2011;82:207–20.CrossRef Kao YC, Liu YP. Suicidal behavior and insight into illness among patients with schizophrenia spectrum disorders. Psychiatry Q. 2011;82:207–20.CrossRef
44.
go back to reference Anderson KK, Flora N, Archie S, et al. A meta-analysis of ethnic differences in pathways to care at the first episode of psychosis. Acta Psychiatr Scand. 2014;130:257–68.CrossRefPubMedPubMedCentral Anderson KK, Flora N, Archie S, et al. A meta-analysis of ethnic differences in pathways to care at the first episode of psychosis. Acta Psychiatr Scand. 2014;130:257–68.CrossRefPubMedPubMedCentral
45.
go back to reference Cauce AM, Domenech-Rodriguez M, Paradise M, et al. Cultural and contextual influences in mental health help seeking: a focus on ethnic minority youth. J Consult Clin Psychol. 2002;70:44–55.CrossRefPubMed Cauce AM, Domenech-Rodriguez M, Paradise M, et al. Cultural and contextual influences in mental health help seeking: a focus on ethnic minority youth. J Consult Clin Psychol. 2002;70:44–55.CrossRefPubMed
46.
go back to reference Commander MJ, Cochrane R, Sashidharan SP, et al. Mental health care for Asian, black and white patients with non-affective psychoses: pathways to the psychiatric hospital, in-patient and after-care. Soc Psychiatry Psychiatr Epidemiol. 1999;34:484–91.CrossRefPubMed Commander MJ, Cochrane R, Sashidharan SP, et al. Mental health care for Asian, black and white patients with non-affective psychoses: pathways to the psychiatric hospital, in-patient and after-care. Soc Psychiatry Psychiatr Epidemiol. 1999;34:484–91.CrossRefPubMed
47.
go back to reference McGovern D, Hemmings P. A follow-up of second generation Afro-Caribbeans and White British with a first admission diagnosis of schizophrenia: attitudes to mental illness and psychiatric services of patients and relatives. Soc Sci Med. 1994;38:117–27.CrossRefPubMed McGovern D, Hemmings P. A follow-up of second generation Afro-Caribbeans and White British with a first admission diagnosis of schizophrenia: attitudes to mental illness and psychiatric services of patients and relatives. Soc Sci Med. 1994;38:117–27.CrossRefPubMed
48.
go back to reference Jarvis GE. The social causes of psychosis in North American psychiatry: a review of a disappearing literature. Can J Psychiatry. 2007;52:287–94.CrossRefPubMed Jarvis GE. The social causes of psychosis in North American psychiatry: a review of a disappearing literature. Can J Psychiatry. 2007;52:287–94.CrossRefPubMed
49.
go back to reference Snowden LR, Yamada AM. Cultural differences in access to care. Annu Rev Clin Psychol. 2005;1:143–66.CrossRefPubMed Snowden LR, Yamada AM. Cultural differences in access to care. Annu Rev Clin Psychol. 2005;1:143–66.CrossRefPubMed
50.
51.
go back to reference Sainsbury P. Validity and reliability of trends in suicide statistics. World Health Stat Q. 1983;36:339–48.PubMed Sainsbury P. Validity and reliability of trends in suicide statistics. World Health Stat Q. 1983;36:339–48.PubMed
52.
go back to reference Voracek M, Loibl LM, Dervic K, et al. Consistency of immigrant suicide rates in Austria with country-of-birth suicide rates: a role for genetic risk factors for suicide? Psychiatry Res. 2009;170(2–3):286–9.CrossRefPubMed Voracek M, Loibl LM, Dervic K, et al. Consistency of immigrant suicide rates in Austria with country-of-birth suicide rates: a role for genetic risk factors for suicide? Psychiatry Res. 2009;170(2–3):286–9.CrossRefPubMed
53.
go back to reference Hjern A, Allebeck P. Suicide in first- and second-generation immigrants in Sweden: a comparative study. Soc Psychiatry Psychiatr Epidemiol. 2002;37:423–9.CrossRefPubMed Hjern A, Allebeck P. Suicide in first- and second-generation immigrants in Sweden: a comparative study. Soc Psychiatry Psychiatr Epidemiol. 2002;37:423–9.CrossRefPubMed
54.
go back to reference Merrill J, Owens J. Self-poisoning among four immigrant groups. Acta Psychiatr Scand. 1988;77:77–80.CrossRefPubMed Merrill J, Owens J. Self-poisoning among four immigrant groups. Acta Psychiatr Scand. 1988;77:77–80.CrossRefPubMed
55.
go back to reference Singh GK, Hiatt RA. Trends and disparities in socioeconomic and behavioural characteristics, life expectancy, and cause specific mortality of native-born and foreign-born populations in the United States, 1979–2003. Int J Epidemiol. 2006;35:903–19.CrossRefPubMed Singh GK, Hiatt RA. Trends and disparities in socioeconomic and behavioural characteristics, life expectancy, and cause specific mortality of native-born and foreign-born populations in the United States, 1979–2003. Int J Epidemiol. 2006;35:903–19.CrossRefPubMed
56.
go back to reference Ratkowska KA, De Leo D. Suicide in Immigrants: An Overview. Open J Med Psychol. 2013;2:124–33.CrossRef Ratkowska KA, De Leo D. Suicide in Immigrants: An Overview. Open J Med Psychol. 2013;2:124–33.CrossRef
58.
go back to reference Clarke DE, Colantonio A, Rhodes AE, Escobar M. Ethnicity and mental health: Conceptualization, definition and operationalization of ethnicity from a Canadian context. Chronic Dis Can. 2008;28:128–47.PubMed Clarke DE, Colantonio A, Rhodes AE, Escobar M. Ethnicity and mental health: Conceptualization, definition and operationalization of ethnicity from a Canadian context. Chronic Dis Can. 2008;28:128–47.PubMed
Metadata
Title
Assessing the risk for suicide in schizophrenia according to migration, ethnicity and geographical ancestry
Authors
Nuwan C. Hettige
Ali Bani-Fatemi
James L. Kennedy
Vincenzo De Luca
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2017
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-016-1180-3

Other articles of this Issue 1/2017

BMC Psychiatry 1/2017 Go to the issue