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Published in: BMC Psychiatry 1/2016

Open Access 01-12-2016 | Research article

A pragmatic randomised multi-centre trial of multifamily and single family therapy for adolescent anorexia nervosa

Authors: Ivan Eisler, Mima Simic, John Hodsoll, Eia Asen, Mark Berelowitz, Frances Connan, Gladys Ellis, Pippa Hugo, Ulrike Schmidt, Janet Treasure, Irene Yi, Sabine Landau

Published in: BMC Psychiatry | Issue 1/2016

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Abstract

Background

Considerable progress has been made in recent years in developing effective treatments for child and adolescent anorexia nervosa, with a general consensus in the field that eating disorders focussed family therapy (often referred to as Maudsley Family Therapy or Family Based Treatment) currently offers the most promising outcomes. Nevertheless, a significant number do not respond well and additional treatment developments are needed to improve outcomes. Multifamily therapy is a promising treatment that has attracted considerable interest and we report the results of the first randomised controlled trial of multifamily therapy for adolescent anorexia nervosa.

Methods

The study was a pragmatic multicentre randomised controlled superiority trial comparing two outpatient eating disorder focussed family interventions - multifamily therapy (MFT-AN) and single family therapy (FT-AN). A total of 169 adolescents with a DSM-IV diagnosis of anorexia nervosa or eating disorder not otherwise specified (restricting type) were randomised to the two treatments using computer generated blocks of random sizes to ensure balanced numbers in the trial arms. Independent assessors, blind to the allocation, completed evaluations at baseline, 3 months, 12 months (end of treatment) and 18 months.

Results

Both treatment groups showed clinically significant improvements with just under 60% achieving a good or intermediate outcome (on the Morgan-Russell scales) at the end of treatment in the FT-AN group and more than 75% in the MFT-AN group - a statistically significant benefit in favour of the multifamily intervention (OR = 2.55 95%; CI 1.17, 5.52; p = 0.019). At follow-up (18 months post baseline) there was relatively little change compared to end of treatment although the difference in primary outcome between the treatments was no longer statistically significant. Clinically significant gains in weight were accompanied by improvements in mood and eating disorder psychopathology. Approximately half the patients in FT-AN and nearly 60% of those in MFT-AN had started menstruating.

Conclusions

This study confirms previous research findings demonstrating the effectiveness of eating disorder focused family therapy and highlights the additional benefits of bringing together groups of families that maximises the use of family resources and mutual support leading to improved outcomes.

Trial Registration

Current Controlled Trials ISRCTN11275465; Registered 29 January 2007 (retrospectively registered)
Footnotes
1
Various labels have been used for eating disorder focussed family therapy including Maudsley Family Therapy, Maudsley Model Therapy and in recent years most commonly Family Based Treatment or FBT. We have argued [19] that such terms are misleading because they imply a theoretically distinct model of treatment rather than a treatment with a shared theoretical frame with other systemic therapies but with a specific focus on treating an eating disorder (very much in the way that “anxiety focussed CBT” or “trauma focussed CBT” are both forms of CBT). The term FBT is also ambiguous because it is sometimes used just to refer to treatments using a specific treatment manual [63] and sometimes to all studies using an eating disorders focussed family therapy. Our use of the term FT-AN emphasizes that this is a treatment that draws on family systems theory and uses a broad range of family therapy intervention techniques while its specificity derives from its focus on treating an eating disorder [64].
 
2
While most adolescent studies have used 18 years as their upper age limit we decided to include a broader age range for two main reasons. First, 18 years is an arbitrary boundary that reflects some changes in a young person’s legal status but certainly does not reflect either a social or biological maturational boundary between adolescence and adulthood. Second, there is increasing recognition that transitions between adolescent and adult services need to be more flexible and we therefore wanted to make sure that our findings would be applicable beyond the narrowly defined boundary between services.
 
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Metadata
Title
A pragmatic randomised multi-centre trial of multifamily and single family therapy for adolescent anorexia nervosa
Authors
Ivan Eisler
Mima Simic
John Hodsoll
Eia Asen
Mark Berelowitz
Frances Connan
Gladys Ellis
Pippa Hugo
Ulrike Schmidt
Janet Treasure
Irene Yi
Sabine Landau
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2016
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-016-1129-6

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