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BMC Psychiatry
Published in: BMC Psychiatry 1/2016

Open Access 01-12-2016 | Study protocol

COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes

Authors: Jilly Naaijen, Saskia de Ruiter, Marcel P. Zwiers, Jeffrey C. Glennon, Sarah Durston, David J. Lythgoe, Steven C. R. Williams, Tobias Banaschewski, Daniel Brandeis, Barbara Franke, Jan K. Buitelaar

Published in: BMC Psychiatry | Issue 1/2016

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Abstract

Background

Compulsivity, the closely linked trait impulsivity and addictive behaviour are associated with several neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive compulsive disorder (OCD). All three disorders show impaired fronto-striatal functioning, which may be related to altered glutamatergic signalling. Genetic factors are also thought to play an important role in the aetiology of compulsivity-related disorders.

Methods

The COMPULS study is a multi-center study designed to investigate the relationship between the traits compulsivity, impulsivity, and, to a lesser extent, addictive behaviour within and across the neurodevelopmental disorders ADHD, ASD, and OCD. This will be done at the phenotypic, cognitive, neural, and genetic level. In total, 240 participants will take part in COMPULS across four different sites in Europe. Data collection will include diagnostic interviews, behavioural questionnaires, cognitive measures, structural, functional and spectral neuroimaging, and genome-wide genetic information.

Discussion

The COMPULS study will offer the unique opportunity to investigate several key aspects of compulsivity across a large cohort of ADHD, ASD and OCD patients.
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Metadata
Title
COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes
Authors
Jilly Naaijen
Saskia de Ruiter
Marcel P. Zwiers
Jeffrey C. Glennon
Sarah Durston
David J. Lythgoe
Steven C. R. Williams
Tobias Banaschewski
Daniel Brandeis
Barbara Franke
Jan K. Buitelaar
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2016
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-016-1072-6

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