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BMC Psychiatry

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Open Access 01-12-2016 | Research article

Normal gray matter volumes in women recovered from anorexia nervosa: a voxel-based morphometry study

Authors: Lasse Bang, Øyvind Rø, Tor Endestad

Published in: BMC Psychiatry | Issue 1/2016

Abstract

Background

Anorexia nervosa (AN) has consistently been associated with reduced gray (GM) and white matter (WM) brain volumes. It is unclear whether GM alterations are present following recovery from AN, as previous findings are inconsistent. The aim of the present study was to determine if women recovered from AN exhibit reduced global or regional GM volumes.

Methods

Global GM and WM, as well as regional GM volumes, were investigated in 22 women recovered from AN and 22 age-matched healthy controls using magnetic resonance imaging. Women were considered recovered if they had maintained a body mass index above 18.0 and had not engaged in binge eating, purging, or restrictive eating behaviors during the past year.

Results

There were no significant differences between recovered AN women and healthy controls in terms of GM and WM volumes. There were also no significant differences between restricting and binging-purging AN subtypes. Lowest lifetime weight was positively correlated with regional GM volumes in the precuneus and insula.

Conclusions

The present study showed that regional GM and global GM and WM volumes were similar for women long-term recovered from AN and age-matched healthy controls. Further research is needed to determine the extent to which illness severity affect regional GM volumes.

Titova O, Hjorth O, Schioth H, Brooks S. Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies. BMC Psychiatry. 2013;13(1):110.CrossRefPubMedPubMedCentral

Van den Eynde F, Suda M, Broadbent H, Guillaume S, Van den Eynde M, Steiger H, et al. Structural magnetic resonance imaging in eating disorders: a systematic review of voxel-based morphometry studies. Eur Eat Disord Rev. 2012;20(2):94–105. doi:10.1002/erv.1163.CrossRefPubMed

Castro-Fornieles J, Bargalló N, Lázaro L, Andrés S, Falcon C, Plana MT, et al. A cross-sectional and follow-up voxel-based morphometric MRI study in adolescent anorexia nervosa. J Psychiatr Res. 2009;43(3):331–40. doi:10.1016/j.jpsychires.2008.03.013.CrossRefPubMed

Katzman DK, Zipursky RB, Lambe EK, Mikulis DJ. A longitudinal magnetic resonance imaging study of brain changes in adolescents with anorexia nervosa. Arch Pediatr Adolesc Med. 1997;151(8):793–7.CrossRefPubMed

Roberto CA, Mayer LES, Brickman AM, Barnes A, Muraskin J, Yeung L-K, et al. Brain tissue volume changes following weight gain in adults with anorexia nervosa. Int J Eat Disord. 2011;44(5):406–11. doi:10.1002/eat.20840.CrossRefPubMed

Friederich HC, Walther S, Bendszus M, Biller A, Thomann P, Zeigermann S, et al. Grey matter abnormalities within cortico-limbic-striatal circuits in acute and weight-restored anorexia nervosa patients. Neuroimage. 2012;59(2):1106–13. doi:10.1016/j.neuroimage.2011.09.042.CrossRefPubMed

Mühlau M, Gaser C, Ilg R, Conrad B, Leibl C, Cebulla MH, et al. Gray matter decrease of the anterior cingulate cortex in anorexia nervosa. Am J Psychiatry. 2007;164(12):1850–7.CrossRefPubMed

Joos A, Hartmann A, Glauche V, Perlov E, Unterbrink T, Saum B, et al. Grey matter deficit in long-term recovered anorexia nervosa patients. Eur Eat Disord Rev. 2011;19(1):59–63. doi:10.1002/erv.1060.CrossRefPubMed

Lambe EK, Katzman DK, Mikulis DJ, Kennedy SH, Zipursky RB. Cerebral gray matter volume deficits after weight recovery from anorexia nervosa. Arch Gen Psychiatry. 1997;54(6):537–42.CrossRefPubMed

10.

Frank GK, Shott ME, Hagman JO, Mittal VA. Alterations in brain structures related to taste reward circuitry in ill and recovered anorexia nervosa and in bulimia nervosa. Am J Psychiatry. 2013;170(10):1152–60.CrossRefPubMedPubMedCentral

11.

Chui HT, Christensen BK, Zipursky RB, Richards BA, Hanratty MK, Kabani NJ, et al. Cognitive function and brain structure in females with a history of adolescent-onset anorexia nervosa. Pediatrics. 2008;122(2):e426–e37. doi:10.1542/peds.2008-0170.CrossRefPubMed

12.

Lázaro L, Andrés S, Calvo A, Cullell C, Moreno E, Plana MT, et al. Normal gray and white matter volume after weight restoration in adolescents with anorexia nervosa. Int J Eat Disord. 2013;46(8):841–8. doi:10.1002/eat.22161.CrossRefPubMed

13.

Mainz V, Schulte-Rüther M, Fink GR, Herpertz-Dahlmann B, Konrad K. Structural brain abnormalities in adolescent anorexia nervosa before and after weight recovery and associated hormonal changes. Psychosom Med. 2012;74(6):574–82.CrossRefPubMed

14.

Wagner A, Greer P, Bailer UF, Frank GK, Henry SE, Putnam K, et al. Normal brain tissue volumes after long-term recovery in anorexia and bulimia nervosa. Biol Psychiatry. 2006;59(3):291–3. doi:10.1016/j.biopsych.2005.06.014.CrossRefPubMed

15.

Gibbon JBW Williams MBFRLSM. Structured clinical interview for DSM-IV-TR axis I disorders, research version, patient edition. (SCID-I/P). New York: Biometrics Research, New York State Psychiatric Institute; 2002.

16.

APA. Diagnostic and statistical manual of mental disorders. 4th ed. Washington: American Psychiatric Association; 2000.

17.

Spielberger CD, Gorsuch RL, Lushene RD. STAI manual. Palo Alto: Calif. Consulting psychologists press; 1970.

18.

Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561–71. doi:10.1001/archpsyc.1961.01710120031004.CrossRefPubMed

19.

Fairburn CG, Beglin SJ. Eating disorder examination questionnaire (EDE-Q 6.0). In: Fairburn CG, editor. Cognitive behavior therapy and eating disorders. New York: Guilford Press; 2008. p. 309–13.

20.

Ashburner J. A fast diffeomorphic image registration algorithm. Neuroimage. 2007;38(1):95–113. doi:10.1016/j.neuroimage.2007.07.007.CrossRefPubMed

21.

Amianto F, Caroppo P, D’Agata F, Spalatro A, Lavagnino L, Caglio M, et al. Brain volumetric abnormalities in patients with anorexia and bulimia nervosa: a voxel-based morphometry study. Psychiatry Res Neuroimaging. 2013;213(3):210–6. doi:10.1016/j.pscychresns.2013.03.010.CrossRefPubMed

22.

Joos A, Klöppel S, Hartmann A, Glauche V, Tüscher O, Perlov E, et al. Voxel-based morphometry in eating disorders: correlation of psychopathology with grey matter volume. Psychiatry Res Neuroimaging. 2010;182:146–51. doi:10.1016/j.pscychresns.2010.02.004.CrossRefPubMed

23.

McCormick LM, Keel PK, Brumm MC, Bowers W, Swayze V, Andersen A, et al. Implications of starvation-induced change in right dorsal anterior cingulate volume in anorexia nervosa. Int J Eat Disord. 2008;41(7):602–10. doi:10.1002/eat.20549.CrossRefPubMedPubMedCentral

24.

D’Agata F, Caroppo P, Amianto F, Spalatro A, Caglio MM, Bergui M, et al. Brain correlates of alexithymia in eating disorders: a voxel-based morphometry study. Psychiatry Clin Neurosci. 2015;69(11):708–16. doi:10.1111/pcn.12318.CrossRefPubMed

25.

Bär K-J, de la Cruz F, Berger S, Schultz CC, Wagner G. Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa. J Psychiatry Neurosci. 2015;1:8872147.

26.

Hammers A, Allom R, Koepp MJ, Free SL, Myers R, Lemieux L, et al. Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum Brain Mapp. 2003;19(4):224–47. doi:10.1002/hbm.10123.CrossRefPubMed

27.

Katzman DK, Lambe EK, Mikulis DJ, Ridgley JN, Goldbloom DS, Zipursky RB. Cerebral gray matter and white matter volume deficits in adolescent girls with anorexia nervosa. J Pediatr. 1996;129(6):794–803. doi:10.1016/S0022-3476(96)70021-5.CrossRefPubMed

28.

Boghi A, Sterpone S, Sales S, D’Agata F, Bradac GB, Zullo G, et al. In vivo evidence of global and focal brain alterations in anorexia nervosa. Psychiatry Res Neuroimaging. 2011;192(3):154–9. doi:10.1016/j.pscychresns.2010.12.008.CrossRefPubMed

29.

Rø Ø, Reas DL, Stedal K. Eating disorder examination questionnaire (EDE-Q) in Norwegian adults: discrimination between female controls and eating disorder patients. Eur Eat Disord Rev. 2015;23(5):408–12. doi:10.1002/erv.2372.CrossRefPubMed

30.

Streitbürger D-P, Möller HE, Tittgemeyer M, Hund-Georgiadis M, Schroeter ML, Mueller K. Investigating structural brain changes of dehydration using voxel-based morphometry. PLoS One. 2012;7(8):e44195.CrossRefPubMedPubMedCentral

31.

Couturier J, Lock J. What is recovery in adolescent anorexia nervosa? Int J Eat Disord. 2006;39(7):550–5. doi:10.1002/eat.20309.CrossRefPubMed

32.

Swayze VW, Andersen AE, Andreasen NC, Arndt S, Sato Y, Ziebell S. Brain tissue volume segmentation in patients with anorexia nervosa before and after weight normalization. Int J Eat Disord. 2003;33(1):33–44. doi:10.1002/eat.10111.CrossRefPubMed

33.

Seitz J, Walter M, Mainz V, Herpertz-Dahlmann B, Konrad K, von Polier G. Brain volume reduction predicts weight development in adolescent patients with anorexia nervosa. J Psychiatr Res. 2015;68:228–37. doi:10.1016/j.jpsychires.2015.06.019.CrossRefPubMed

34.

Altman DG, Bland JM. Statistics notes: absence of evidence is not evidence of absence. BMJ. 1995;311(7003):485. doi:10.1136/bmj.311.7003.485.CrossRefPubMedPubMedCentral

Title: Normal gray matter volumes in women recovered from anorexia nervosa: a voxel-based morphometry study
Authors: Lasse Bang
Øyvind Rø
Tor Endestad
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: BMC Psychiatry / Issue 1/2016
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-016-0856-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Normal gray matter volumes in women recovered from anorexia nervosa: a voxel-based morphometry study

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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