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BMC Psychiatry
Published in: BMC Psychiatry 1/2016

Open Access 01-12-2016 | Study protocol

Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort

Authors: Raymond W. Lam, Roumen Milev, Susan Rotzinger, Ana C. Andreazza, Pierre Blier, Colleen Brenner, Zafiris J. Daskalakis, Moyez Dharsee, Jonathan Downar, Kenneth R. Evans, Faranak Farzan, Jane A. Foster, Benicio N. Frey, Joseph Geraci, Peter Giacobbe, Harriet E. Feilotter, Geoffrey B. Hall, Kate L. Harkness, Stefanie Hassel, Zahinoor Ismail, Francesco Leri, Mario Liotti, Glenda M. MacQueen, Mary Pat McAndrews, Luciano Minuzzi, Daniel J. Müller, Sagar V. Parikh, Franca M. Placenza, Lena C. Quilty, Arun V. Ravindran, Tim V. Salomons, Claudio N. Soares, Stephen C. Strother, Gustavo Turecki, Anthony L. Vaccarino, Fidel Vila-Rodriguez, Sidney H. Kennedy, on behalf of the CAN-BIND Investigator Team

Published in: BMC Psychiatry | Issue 1/2016

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Abstract

Background

Major Depressive Disorder (MDD) is among the most prevalent and disabling medical conditions worldwide. Identification of clinical and biological markers (“biomarkers”) of treatment response could personalize clinical decisions and lead to better outcomes. This paper describes the aims, design, and methods of a discovery study of biomarkers in antidepressant treatment response, conducted by the Canadian Biomarker Integration Network in Depression (CAN-BIND). The CAN-BIND research program investigates and identifies biomarkers that help to predict outcomes in patients with MDD treated with antidepressant medication. The primary objective of this initial study (known as CAN-BIND-1) is to identify individual and integrated neuroimaging, electrophysiological, molecular, and clinical predictors of response to sequential antidepressant monotherapy and adjunctive therapy in MDD.

Methods

CAN-BIND-1 is a multisite initiative involving 6 academic health centres working collaboratively with other universities and research centres. In the 16-week protocol, patients with MDD are treated with a first-line antidepressant (escitalopram 10–20 mg/d) that, if clinically warranted after eight weeks, is augmented with an evidence-based, add-on medication (aripiprazole 2–10 mg/d). Comprehensive datasets are obtained using clinical rating scales; behavioural, dimensional, and functioning/quality of life measures; neurocognitive testing; genomic, genetic, and proteomic profiling from blood samples; combined structural and functional magnetic resonance imaging; and electroencephalography. De-identified data from all sites are aggregated within a secure neuroinformatics platform for data integration, management, storage, and analyses. Statistical analyses will include multivariate and machine-learning techniques to identify predictors, moderators, and mediators of treatment response.

Discussion

From June 2013 to February 2015, a cohort of 134 participants (85 outpatients with MDD and 49 healthy participants) has been evaluated at baseline. The clinical characteristics of this cohort are similar to other studies of MDD. Recruitment at all sites is ongoing to a target sample of 290 participants. CAN-BIND will identify biomarkers of treatment response in MDD through extensive clinical, molecular, and imaging assessments, in order to improve treatment practice and clinical outcomes. It will also create an innovative, robust platform and database for future research.

Trial registration

ClinicalTrials.gov identifier NCT01655706. Registered July 27, 2012.
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Metadata
Title
Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort
Authors
Raymond W. Lam
Roumen Milev
Susan Rotzinger
Ana C. Andreazza
Pierre Blier
Colleen Brenner
Zafiris J. Daskalakis
Moyez Dharsee
Jonathan Downar
Kenneth R. Evans
Faranak Farzan
Jane A. Foster
Benicio N. Frey
Joseph Geraci
Peter Giacobbe
Harriet E. Feilotter
Geoffrey B. Hall
Kate L. Harkness
Stefanie Hassel
Zahinoor Ismail
Francesco Leri
Mario Liotti
Glenda M. MacQueen
Mary Pat McAndrews
Luciano Minuzzi
Daniel J. Müller
Sagar V. Parikh
Franca M. Placenza
Lena C. Quilty
Arun V. Ravindran
Tim V. Salomons
Claudio N. Soares
Stephen C. Strother
Gustavo Turecki
Anthony L. Vaccarino
Fidel Vila-Rodriguez
Sidney H. Kennedy
on behalf of the CAN-BIND Investigator Team
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2016
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-016-0785-x

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