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BMC Psychiatry

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Open Access 01-12-2014 | Research article

Early risk factors for adult bipolar disorder in adolescents with mood disorders: a 15-year follow-up of a community sample

Authors: Aivar Päären, Hannes Bohman, Lars von Knorring, Gunilla Olsson, Anne-Liis von Knorring, Ulf Jonsson

Published in: BMC Psychiatry | Issue 1/2014

Abstract

Background

We aimed to outline the early risk factors for adult bipolar disorder (BPD) in adolescents with mood disorders.

Methods

Adolescents (16–17 years old) with mood disorders (n = 287; 90 participants with hypomania spectrum episodes and 197 with major depressive disorder [MDD]) were identified from a community sample. Fifteen years later (at 30–33 years of age), mood episodes were assessed (n = 194). The risk of developing BPD (n = 22), compared with MDD (n = 104) or no mood episodes in adulthood (n = 68), was estimated via logistic regression. Adolescent mood symptoms, non-mood disorders, and family characteristics were assessed as potential risk factors.

Results

Among the adolescents with mood disorders, a family history of BPD was the strongest predictor of developing BPD compared with having no mood episodes in adulthood (OR = 5.94; 95% CI = 1.11-31.73), whereas disruptive disorders significantly increased the risk of developing BPD compared with developing MDD (OR = 2.94; CI = 1.06-8.12). The risk that adolescents with MDD would develop adult BPD, versus having no mood episodes in adulthood, was elevated among those with an early disruptive disorder (OR = 3.62; CI = 1.09-12.07) or multiple somatic symptoms (OR = 6.60; CI = 1.70-25.67). Only disruptive disorders significantly predicted adult BPD among adolescents with MDD versus continued MDD in adulthood (OR = 3.59; CI = 1.17-10.97). Only a few adolescents with hypomania spectrum episodes continued to have BPD as adults, and anxiety disorders appeared to increase this risk.

Conclusions

Although most of the identified potential risk factors are likely general predictors of continued mood disorders, disruptive disorders emerged as specific predictors of developing adult BPD among adolescents with MDD.

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Title: Early risk factors for adult bipolar disorder in adolescents with mood disorders: a 15-year follow-up of a community sample
Authors: Aivar Päären
Hannes Bohman
Lars von Knorring
Gunilla Olsson
Anne-Liis von Knorring
Ulf Jonsson
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Psychiatry / Issue 1/2014
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-014-0363-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Early risk factors for adult bipolar disorder in adolescents with mood disorders: a 15-year follow-up of a community sample

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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