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BMC Psychiatry
Published in: BMC Psychiatry 1/2014

Open Access 01-12-2014 | Study protocol

Mindfulness-based cognitive therapy in obsessive-compulsive disorder: protocol of a randomized controlled trial

Authors: Anne Katrin Külz, Sarah Landmann, Barbara Cludius, Birgit Hottenrott, Nina Rose, Thomas Heidenreich, Elisabeth Hertenstein, Ulrich Voderholzer, Steffen Moritz

Published in: BMC Psychiatry | Issue 1/2014

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Abstract

Background

Obsessive-compulsive disorder (OCD) is a very disabling condition with a chronic course, if left untreated. Though cognitive behavioral treatment (CBT) with or without selective serotonin reuptake inhibitors (SSRI) is the method of choice, up to one third of individuals with obsessive-compulsive disorder (OCD) do not respond to treatment in terms of at least 35% improvement of symptoms. Mindfulness based cognitive therapy (MBCT) is an 8-week group program that could help OCD patients with no or only partial response to CBT to reduce OC symptoms and develop a helpful attitude towards obsessions and compulsive urges.

Methods/design

This study is a prospective, bicentric, assessor-blinded, randomized, actively-controlled clinical trial. 128 patients with primary diagnosis of OCD according to DSM-IV and no or only partial response to CBT will be recruited from in- and outpatient services as well as online forums and the media. Patients will be randomized to either an MBCT intervention group or to a psycho-educative coaching group (OCD-EP) as an active control condition. All participants will undergo eight weekly sessions with a length of 120 minutes each of a structured group program. We hypothesize that MBCT will be superior to OCD-EP in reducing obsessive-compulsive symptoms as measured by the Yale-Brown-Obsessive-Compulsive Scale (Y-BOCS) following the intervention and at 6- and 12-months-follow-up. Secondary outcome measures include depressive symptoms, quality of life, metacognitive beliefs, self-compassion, mindful awareness and approach-avoidance tendencies as measured by an approach avoidance task.

Discussion

The results of this study will elucidate the benefits of MBCT for OCD patients who did not sufficiently benefit from CBT. To our knowledge, this is the first randomized controlled study assessing the effects of MBCT on symptom severity and associated parameters in OCD.

Trial registration

German Clinical Trials Register DRKS00004525. Registered 19 March 2013.
Appendix
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Metadata
Title
Mindfulness-based cognitive therapy in obsessive-compulsive disorder: protocol of a randomized controlled trial
Authors
Anne Katrin Külz
Sarah Landmann
Barbara Cludius
Birgit Hottenrott
Nina Rose
Thomas Heidenreich
Elisabeth Hertenstein
Ulrich Voderholzer
Steffen Moritz
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2014
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-014-0314-8

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